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    Pyrrolidine derivatives having inhibitory action for proline specific endopepidase
    2.
    发明授权
    Pyrrolidine derivatives having inhibitory action for proline specific endopepidase 失效
    对脯氨酸特异性内肽酶具有抑制作用的吡咯烷衍生物

    公开(公告)号：US4880827A

    公开(公告)日：1989-11-14

    申请号：US25664

    申请日：1987-03-13

    申请人： Katsumi Tamoto ,  Renzo Ohuchi ,  Keiichi Ono

    发明人： Katsumi Tamoto ,  Renzo Ohuchi ,  Keiichi Ono

    IPC分类号： C07D207/08

    CPC分类号： C07D207/08

    摘要： Pyrrolidine derivatives having inhibitory action for proline-specific endopeptidase which are useful for anti-amnestic agent. The disclosed pyrrolidine derivatives as well as their acid addition salts can be administered orally or parenterally in the form of conventional pharmaceutical preparations. For instance, they can be administered orally in the form of conventional solid pharmaceutical preparations such as tablets, capsules, syrups and suspensions. Alternatively, they can be administered parenterally by injection in the form of conventional liquid pharmaceutical preparations such as solutions, emulsions, suspensions, etc. Also, they may be directly applied to rectum in the form of suppository. Further, the preparations may contain physiologically acceptable carriers, excipients, activators, binding agents, stabilizers, etc. In the case of injections, physiologically acceptable buffers, solubilizing agents or isotonic agents may be incorporated therein. Methods of production are also disclosed.

    摘要翻译： 具有抑制脯氨酸特异性内肽酶的作用的吡咯烷衍生物可用于抗惊厥剂。 公开的吡咯烷衍生物及其酸加成盐可以以常规药物制剂的形式口服或肠胃外给药。 例如，它们可以以常规固体药物制剂如片剂，胶囊，糖浆和悬浮液的形式口服给药。 或者，它们可以以常规液体药物制剂如溶液，乳剂，悬浮液等的形式通过注射肠胃外给药。此外，它们可以以栓剂的形式直接施用于直肠。 此外，制剂可以含有生理上可接受的载体，赋形剂，活化剂，结合剂，稳定剂等。在注射的情况下，可以加入生理上可接受的缓冲剂，增溶剂或等渗剂。 还公开了生产方法。

    Safety cabinet
    3.
    发明授权
    Safety cabinet 有权
    安全柜

    公开(公告)号：US08382873B2

    公开(公告)日：2013-02-26

    申请号：US13429832

    申请日：2012-03-26

    申请人： Keiichi Ono

    发明人： Keiichi Ono

    IPC分类号： B01D46/00

    CPC分类号： F24F7/007 ,  A47B9/00 ,  A47B81/00 ,  A47B2200/0019 ,  B08B15/023 ,  B25H1/20 ,  F24F3/1607 ,  Y10S55/18

    摘要： A safety cabinet can adapt to variations in body height of a worker or user. The safety cabinet prevents various bacteria from proceeding from the outside of the safety cabinet into a working space of the safety cabinet and prevents bacteria or viruses from proceeding from the working space to the outside of the safety cabinet irrespective of a change in opening area of a front opening. A flow velocity of clean air supplied into the working space and a flow velocity of the air flowing through the front opening are set in accordance with a size of the front opening to maintain physical isolation and prevent contamination. The size of the front opening of the safety cabinet is adjustable.

    摘要翻译： 安全柜可以适应工作人员或使用者身高的变化。 安全柜防止各种细菌从安全柜的外部进入安全柜的工作空间，并防止细菌或病毒从工作空间进入安全柜的外部，而不管开启面积如何变化 前开口 供给到工作空间的清洁空气的流速和流过前开口的空气的流速根据前开口的尺寸设定，以保持物理隔离并防止污染。 安全柜的前开口尺寸可调。

    Safety cabinet for antibiohazard
    4.
    发明申请
    Safety cabinet for antibiohazard 有权

    公开(公告)号：US20060150593A1

    公开(公告)日：2006-07-13

    申请号：US11362848

    申请日：2006-02-28

    申请人： Keiichi Ono

    发明人： Keiichi Ono

    IPC分类号： B01D46/00

    CPC分类号： B01L1/04 ,  B01L2200/082 ,  B01L2300/0681 ,  B08B15/023 ,  B08B2215/003 ,  F24F3/1607 ,  Y10S55/18 ,  Y10S55/29 ,  Y10S55/46

    摘要： A safety cabinet which can prevent contaminated air from leaking from a working space through the periphery of a front shutter, and which can prevent outside air from entering the working space has a peripheral structure part surrounding the working space formed with air suction ports in a part opposed to the inner surface of the front shutter connected to a negative pressure passage formed outside of the working space. The negative pressure passage guides air sucked through the air suction ports from the inside and the outside of the working space, toward a filter for purification of the air.

    Process for producing eburnane derivatives
    5.
    发明授权
    Process for producing eburnane derivatives 失效
    生产伊本恩衍生物的方法

    公开(公告)号：US4316028A

    公开(公告)日：1982-02-16

    申请号：US93606

    申请日：1979-11-13

    申请人： Junki Katsube ,  Keiichi Ono ,  Hajime Kawakami

    发明人： Junki Katsube ,  Keiichi Ono ,  Hajime Kawakami

    IPC分类号： C07D461/00 ,  C07D471/14

    CPC分类号： C07D471/14 ,  C07D461/00

    摘要： A compound of the formula: ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.6 alkyl group and R is a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group, and their salts, which are useful as cerebral vasodilator; and a compound of the formula: ##STR2## wherein R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group, R.sup.3 is a hydrogen atom or the formula: --CO.sub.2 R.sup.1 (R.sup.1 is a C.sub.1 -C.sub.6 alkyl group) and W is an oxygen atom, an imino group or ##STR3## but not an imino group in case that R.sup.3 is a hydrogen atom, which are intermediates of the compound (I), useful per se as cerebral vasodilator and/or antihypertensive agents.

    摘要翻译： 下式的化合物：其中R1是C1-C6烷基，R是氢原子或C1-C6烷基，它们的盐可用作脑血管扩张剂; 和下式的化合物：其中R 2是氢原子或C 1 -C 6烷基，R 3是氢原子或式-CO 2 R 1（R 1是C 1 -C 6烷基）和W 在R3是氢原子的情况下是氧原子，亚氨基或亚氨基，而不是亚氨基，它是作为脑血管扩张剂和/或抗高血压药物的化合物（I）的中间体。

    Butyrophenone compounds
    6.
    发明授权
    Butyrophenone compounds 失效
    丁基苯酚化合物

    公开(公告)号：US4303663A

    公开(公告)日：1981-12-01

    申请号：US795145

    申请日：1977-05-09

    申请人： Kikuo Sasajima ,  Keiichi Ono ,  Masaru Nakao ,  Hisao Yamamoto

    发明人： Kikuo Sasajima ,  Keiichi Ono ,  Masaru Nakao ,  Hisao Yamamoto

    IPC分类号： C07D295/10 ,  A61K31/435 ,  A61K31/443 ,  A61K31/445 ,  A61K31/451 ,  A61P9/12 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/20 ,  A61P29/00 ,  C07D211/14 ,  C07D211/52 ,  C07D405/06 ,  C07D471/10

    CPC分类号： C07D211/52

    摘要： Butyrophenone compounds having excellent psychotropic activities represented by the formula: ##STR1## wherein R.sup.1 is a halogen atom, R.sup.2 is a lower alkyl group, and Z is a group of either one of the formulae: ##STR2## (wherein the dotted line indicates the optional presence of an additional single bond linkage, R.sup.3 is a hydrogen atom or a hydroxyl group but only when said additional single bond linkage is not present and R.sup.4 is a hydrogen atom or a phenyl or benzyl group optionally substituted with one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy and trifluoromethyl on the benzene ring (except monohalophenyl)), ##STR3## (wherein the dotted line indicates the optional presence of an additional single bond linkage, R.sup.5 is a hydrogen atom or a lower alkyl group and R.sup.6 and R.sup.7 are each a hydrogen atom, a halogen atom or a lower alkyl group), ##STR4## (wherein R.sup.8 is a hydrogen atom or a lower alkyl group and R.sup.9 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group), ##STR5## (wherein R.sup.10 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group), or ##STR6##

    Biosafety cabinetry
    8.
    发明授权
    Biosafety cabinetry 有权
    生物安全柜

    公开(公告)号：US09144910B2

    公开(公告)日：2015-09-29

    申请号：US13186807

    申请日：2011-07-20

    申请人： Keiichi Ono ,  Tomotaka Kodama

    发明人： Keiichi Ono ,  Tomotaka Kodama

    IPC分类号： B25J21/02

    CPC分类号： B25J21/02

    摘要： The workability of operation to be performed, while preventing chemical or biological contamination, using a biosafety cabinet and gloves attached to the cabinet is improved. A biosafety cabinet includes a workspace formed in a main body cabinet thereof. Air in the workspace is discharged to outside via filters. A vertically movable front shutter is disposed on a front of the workspace. A front opening is formed below the front shutter to be at a front of the workspace. The front shutter includes plural laterally movable small windows which are overlapped like layered sliding doors. One of the plural small windows is provided, on the workspace side thereof, with a pair of glove ports to which a pair of gloves for use in operation in the workspace can be air-tightly attached.

    摘要翻译： 改善了使用生物安全柜和附着在机柜上的手套的同时防止化学或生物污染的操作的可操作性。 生物安全柜包括在其主体机壳中形成的工作空间。 工作区内的空气通过过滤器排放到室外。 可垂直移动的前挡板设置在工作空间的前部。 在前挡板下面形成一个前开口，位于工作区的前方。 前挡板包括与层状滑动门重叠的多个横向可移动小窗。 多个小窗口中的一个在其工作空间侧上设置有一对手套端口，用于在工作空间中操作的一对手套可以气密地附着在该端口上。

    Safety cabinet
    9.
    发明授权
    Safety cabinet 有权
    安全柜

    公开(公告)号：US08163052B2

    公开(公告)日：2012-04-24

    申请号：US11869962

    申请日：2007-10-10

    申请人： Keiichi Ono

    发明人： Keiichi Ono

    IPC分类号： B01D46/00

    CPC分类号： F24F7/007 ,  A47B9/00 ,  A47B81/00 ,  A47B2200/0019 ,  B08B15/023 ,  B25H1/20 ,  F24F3/1607 ,  Y10S55/18

    摘要： A safety cabinet adaptable for a variation in body height of a worker using the safety cabinet, that is, a safety cabinet which prevents various bacteria from proceeding from the outside of the safety cabinet into a working space of the safety cabinet and prevents bacteria or virus from proceeding from the working space to the outside of the safety cabinet irrespective of a change in opening area of a front opening, is provided. A flow velocity of a clean air supplied into the working space and a flow velocity of the air flowing through the front opening are set at respective velocities predetermined to keep a physical isolation for preventing the contamination in accordance with a size of the front opening. Further, in the safety cabinet, the size of the front opening communicating with the working space under the front surface shutter is adjustable between 200 mm and 300 m.

    摘要翻译： 一种安全柜，适用于使用安全柜的工人的身高变化，即安全柜，防止各种细菌从安全柜的外部进入安全柜的工作空间，并防止细菌或病毒 提供了从工作空间到安全柜的外部，而不管前开口的开口面积的变化。 供给到工作空间的清洁空气的流速和流过前开口的空气的流速被设定为预定的相应速度，以保持物理隔离以防止根据前开口的尺寸的污染。 此外，在安全柜中，与前表面闸板下方的工作空间连通的前开口的尺寸可在200mm和300m之间调节。

    Safety cabinet for antibiohazard
    10.
    发明授权
    Safety cabinet for antibiohazard 有权
    防腐柜安全柜

    公开(公告)号：US07090709B2

    公开(公告)日：2006-08-15

    申请号：US10650820

    申请日：2003-08-29

    申请人： Keiichi Ono

    发明人： Keiichi Ono

    IPC分类号： B01D46/00

    CPC分类号： B01L1/04 ,  B01L2200/082 ,  B01L2300/0681 ,  B08B15/023 ,  B08B2215/003 ,  F24F3/1607 ,  Y10S55/18 ,  Y10S55/29 ,  Y10S55/46

    摘要： A safety cabinet which can prevent contaminated air from leaking from a working space through the periphery of a front shutter, and which can prevent outside air from entering the working space has a peripheral structure part surrounding the working space formed with air suction ports in a part opposed to the inner surface of the front shutter connected to a negative pressure passage formed outside of the working space. The negative pressure passage guides air sucked through the air suction ports from the inside and the outside of the working space, toward a filter for purification of the air.

    摘要翻译： 一种能够防止被污染的空气通过前挡板的周边从工作空间泄漏并且可以防止外部空气进入工作空间的安全柜具有围绕由一部分中的空气吸入口形成的工作空间的周边结构部分 与连接到形成在工作空间外部的负压通道的前快门的内表面相对。 负压通道将从空气吸入口吸入的空气从工作空间的内部和外部引导到用于净化空气的过滤器。