LAMINATED TABLET AND MANUFACTURING METHOD THEREFOR
    1.
    发明申请
    LAMINATED TABLET AND MANUFACTURING METHOD THEREFOR 有权
    层压板及其制造方法

    公开(公告)号:US20140023708A1

    公开(公告)日:2014-01-23

    申请号:US14002451

    申请日:2012-03-02

    IPC分类号: A61K9/20

    摘要: According to the present invention, a multilayer tablet showing suppressed layer separation and a production method thereof are provided. A concave portion having a depth of not less than 0.1 mm Ka is formed on at least one surface Sa of the both front and back surfaces (Sa, Sb) of a multilayer tablet. Particularly, a multilayer structure obtained by, in tableting, forming a convex portion for forming the concave portion on at least the upper punch, and preliminarily compressing all layers in the multilayer tablet with the upper punch to form a concave portion having the same shape with a depth of not less than 0.1 mm on the upper surface of all layers, wherein the powder materials of the next layer are protruding into the concave portion, is a preferable embodiment.

    摘要翻译: 根据本发明,提供了显示抑制层分离的多层片剂及其制备方法。 在多层片剂的前表面(Sa,Sb)的至少一个表面Sa上形成具有不小于0.1mm的深度的凹部的凹部。 特别是,通过在至少在上冲头上形成用于形成凹部的凸部的压片成型,并用上冲头预先压缩多层片剂中的所有层而形成具有相同形状的凹部而获得的多层结构, 在所有层的上表面上的深度不小于0.1mm,其中下一层的粉末材料突出到凹部中,是优选的实施方案。

    Laminated tablet and manufacturing method therefor
    2.
    发明授权
    Laminated tablet and manufacturing method therefor 有权
    层压片及其制造方法

    公开(公告)号:US09326946B2

    公开(公告)日:2016-05-03

    申请号:US14002451

    申请日:2012-03-02

    IPC分类号: A61K9/20 A61K9/24 A61K45/06

    摘要: According to the present invention, a multilayer tablet showing suppressed layer separation and a production method thereof are provided. A concave portion having a depth of not less than 0.1 mm Ka is formed on at least one surface Sa of the both front and back surfaces (Sa, Sb) of a multilayer tablet. Particularly, a multilayer structure obtained by, in tableting, forming a convex portion for forming the concave portion on at least the upper punch, and preliminarily compressing all layers in the multilayer tablet with the upper punch to form a concave portion having the same shape with a depth of not less than 0.1 mm on the upper surface of all layers, wherein the powder materials of the next layer are protruding into the concave portion, is a preferable embodiment.

    摘要翻译: 根据本发明,提供了显示抑制层分离的多层片剂及其制备方法。 在多层片剂的前表面(Sa,Sb)的至少一个表面Sa上形成有不小于0.1mm的深度的凹部的凹部。 特别是,通过在至少在上冲头上形成用于形成凹部的凸部的压片成型,并用上冲头预先压缩多层片剂中的所有层而形成具有相同形状的凹部而获得的多层结构, 在所有层的上表面上的深度不小于0.1mm,其中下一层的粉末材料突出到凹部中,是优选的实施方案。