摘要:
A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.
摘要:
A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.
摘要翻译:由下式(I)表示的化合物,其盐或其水合物可以有效地缓解由特应性疾病等引起的瘙痒:其中R表示羟基,C 1-6烷氧基,其任选被 C 1-6烷氧基或任选被C 1-6烷基取代的氨基。
摘要:
The present invention discloses compounds and compositions of formula (I): having inhibitory activity on activation of STAT6, wherein X represents quinoline, isoquinoline, quinazoline or imidazopyridine; Y represents phenyl, piperazine, pyridine, thiophene, thiazole, oxathiazole or oxathiadiazole; and variables Z, n, R1, R2, R3 and R4 are as defined in the claims.
摘要:
To provide a cyclohexane derivative defined by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen or lower alkyl; R.sup.3 represents optionally substituted aryl or optionally substituted heteroaryl; X represents oxygen or sulfur; and Y represents a group represented by the formula: ##STR2## or the like). The compound of the present invention is useful as a preventive and therapeutic agent for diseases against which a potassium channel opening action is efficacious.
摘要翻译:提供由式(I)定义的环己烷衍生物或其药理学上可接受的盐:其中R 1和R 2可以彼此相同或不同,各自表示氢或低级烷基; R 3表示任选地 取代的芳基或任选取代的杂芳基; X表示氧或硫; Y表示由下式表示的基团:所发明的发明可用作钾通道开放作用有效的疾病的预防和治疗剂。
摘要:
In a nonhuman animal model that produces a secretory protein, which is obtained by transplanting secretory protein-expression vector-transfected cells into a nonhuman animal, an amount of the secretory protein is measured and, based on the amount of the secretory protein, transcriptional activity, number of the transplanted cells, and tumor volume is measured. Further, screening of a compound that affects a transcriptional activity, number of transplanted cells, or tumor volume is performed by using the nonhuman animal model to which a compound has been administered.
摘要:
To provide a novel cyclohexane derivative, a cyclohexane derivative is defined by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen or lower alkyl; R.sup.3 represents optionally substituted aryl or optionally substituted heteroaryl; X represents oxygen or sulfur; and Y represents a group represented by the formula: ##STR2## or the like). The compound of the present invention is useful as a preventive and therapeutic agent for diseases against which a potassium channel opening action is efficacious.
摘要翻译:为了提供新的环己烷衍生物,环己烷衍生物由式(I)或其药理学上可接受的盐定义:其中R 1和R 2可以彼此相同或不同,并且各自表示氢或 低级烷基; R 3表示任选取代的芳基或任选取代的杂芳基; X表示氧或硫; Y表示由下式表示的基团:等等)。 本发明的化合物可用作钾通道开放作用有效的疾病的预防和治疗剂。