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公开(公告)号：US20120083488A1
公开(公告)日：2012-04-05
申请号：US13377300
申请日：2010-06-09
申请人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yashuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
发明人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yashuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
IPC分类号： A61K31/454 , C07D405/12 , C07D413/12 , C07D417/10 , C07D403/10 , C07D409/10 , C07D209/80 , C07D471/04 , C07D491/048 , C07D401/10 , C07D401/14 , C07D491/107 , C07D413/14 , C07D417/12 , A61K31/55 , A61K31/343 , A61K31/506 , A61K31/4525 , A61K31/4025 , A61K31/496 , A61K31/443 , A61K31/4178 , A61K31/5377 , A61K31/427 , A61K31/4155 , A61K31/403 , A61K31/4355 , A61K31/407 , A61K31/541 , A61K31/4545 , A61P35/00 , A61P35/04 , A61P25/24 , A61P25/28 , A61K31/437 , C07D307/77
CPC分类号： C07D209/58 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/7056 , C07D209/56 , C07D209/88 , C07D307/77 , C07D307/78 , C07D307/92 , C07D333/50 , C07D333/52 , C07D333/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/107 , C07F7/0834 , C07H15/26
摘要： A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
摘要翻译： 由下述通式（I）表示的化合物或其盐或溶剂化物，其可用作ALK抑制剂，并且可用于预防或治疗伴有ALK异常的疾病，例如癌症，癌症转移 ，抑郁症或认知功能障碍（包括在公式中的符号的含义如说明书中所给出）。
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公开(公告)号：US09126931B2
公开(公告)日：2015-09-08
申请号：US13377300
申请日：2010-06-09
申请人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yasuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
发明人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yasuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
IPC分类号： C07D207/30 , C07D209/80 , C07D333/50 , C07D307/77 , C07D209/56 , C07D209/88 , C07D307/92 , C07D333/76 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/107
CPC分类号： C07D209/58 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/7056 , C07D209/56 , C07D209/88 , C07D307/77 , C07D307/78 , C07D307/92 , C07D333/50 , C07D333/52 , C07D333/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/107 , C07F7/0834 , C07H15/26
摘要： A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
摘要翻译： 由下述通式（I）表示的化合物或其盐或溶剂化物，其可用作ALK抑制剂，并且可用于预防或治疗伴有ALK异常的疾病，例如癌症，癌症转移 ，抑郁症或认知功能障碍（包括在公式中的符号的含义如说明书中所给出）。
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公开(公告)号：US07074777B2
公开(公告)日：2006-07-11
申请号：US10257868
申请日：2001-04-18
IPC分类号： A61K31/59 , C07C401/00
CPC分类号： C07C401/00 , C07F7/1804 , Y02P20/55 , Y10S514/863
摘要： The object of the present invention is to provide a vitamin D derivative exhibiting excellent physiological activity as medicines, in particular as therapeutic agents for skin disease including psoriasis, and having decreased hypercalcemic activity.The present invention provides vitamin D derivatives represented by the general Formula (1): wherein in Formula (1), X is oxygen or sulfur; R1 is hydrogen or Formula (2) R2 is hydrogen or alkyl; R3 and R4 are hydrogen or alkyl or R3 and R4 together form a double bond between the 16- and 17-positions; R5 is hydrogen or —OR13 in which R13 is hydrogen or a protecting group; and R6 is hydrogen or a protecting group.
摘要翻译： 本发明的目的是提供作为药物，特别是作为包括银屑病在内的皮肤疾病的治疗剂，具有降低的高钙血症活性的作为药物的优异生理活性的维生素D衍生物。 本发明提供由通式（1）表示的维生素D衍生物：其中在式（1）中，X为氧或硫; R 1是氢或式（2）R 2是氢或烷基; R 3和R 4是氢或烷基或R 3和R 4共同形成双键 16位和17位; R 5是氢或-OR 13，其中R 13是氢或保护基; 并且R 6是氢或保护基。
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公开(公告)号：US08212059B2
公开(公告)日：2012-07-03
申请号：US12095734
申请日：2006-11-30
申请人： Akira Kawase , Yasuharu Kato , Kazutomo Kinoshita , Yasushi Kitoh , Takuma Ikeda , Tsuyoshi Haneishi , Noriaki Maruyama , Mio Kobayashi
发明人： Akira Kawase , Yasuharu Kato , Kazutomo Kinoshita , Yasushi Kitoh , Takuma Ikeda , Tsuyoshi Haneishi , Noriaki Maruyama , Mio Kobayashi
IPC分类号： C07C401/00 , C07J21/00
CPC分类号： C07C401/00 , C07J41/00 , C07J71/00
摘要： There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(19),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide, which process is characterized by irradiating a compound represented by the formula: with UV to ring-open the compound, and then isomerizing the resulting compound; an intermediate useful for carrying out the process; and a process for producing the intermediate.
摘要翻译： 提供了一种制备[{（5Z，7E） - （1S，3R，20S）-1,3-二羟基-9,10-断孕甾-5,7,10（19），16-四烯-20 - 基}氧基] -N-（2,2,3,3,3-五氟丙基）乙酰胺，该方法的特征在于用UV照射化合物以紫外线打开化合物，然后异构化所得 复合; 用于执行该过程的中间件; 和中间体的制造方法。
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公开(公告)号：US20100261917A1
公开(公告)日：2010-10-14
申请号：US12095734
申请日：2006-11-30
申请人： Akira Kawase , Yasuharu Kato , Kazutomo Kinoshita , Yasushi Kitoh , Takuma Ikeda , Tsuyoshi Haneishi , Noriaki Maruyama , Mio Kobayashi
发明人： Akira Kawase , Yasuharu Kato , Kazutomo Kinoshita , Yasushi Kitoh , Takuma Ikeda , Tsuyoshi Haneishi , Noriaki Maruyama , Mio Kobayashi
CPC分类号： C07C401/00 , C07J41/00 , C07J71/00
摘要： There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(19),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide, which process is characterized by irradiating a compound represented by the formula: with UV to ring-open the compound, and then isomerizing the resulting compound; an intermediate useful for carrying out the process; and a process for producing the intermediate.
摘要翻译： 提供了一种制备[{（5Z，7E） - （1S，3R，20S）-1,3-二羟基-9,10-断孕甾-5,7,10（19），16-四烯-20 - 基}氧基] -N-（2,2,3,3,3-五氟丙基）乙酰胺，该方法的特征在于用UV照射化合物以紫外线打开化合物，然后异构化所得 复合; 用于执行该过程的中间件; 和中间体的制造方法。
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