公开(公告)号：US4742165A

公开(公告)日：1988-05-03

申请号：US865566

申请日：1986-05-02

申请人： Keiichi Yokoyama ,  Tatsuyoshi Ishida ,  Shigeru Isayama ,  Kohji Kato ,  Takumi Kitahara ,  Yoshiaki Furuya

发明人： Keiichi Yokoyama ,  Tatsuyoshi Ishida ,  Shigeru Isayama ,  Kohji Kato ,  Takumi Kitahara ,  Yoshiaki Furuya

IPC分类号： A01N43/60 ,  A01N43/90 ,  C07D239/84 ,  C07D471/04 ,  C07D487/04 ,  C07D239/70

CPC分类号： C07D471/04 ,  A01N43/60 ,  A01N43/90 ,  C07D239/84 ,  C07D487/04

摘要： The present invention relates to novel 2-piperazinopyrimidine derivatives represented by the following general formula [I] which are useful as, for example, an active ingredient of herbicides ##STR1## wherein R.sup.1 is a hydrogen atom or an aralkyl group and Y is one of the groups represented by the following general formulas [II] to [VII] ##STR2## (wherein a and b are positions to be bound to positions 4 and 5 of the pyrimidine ring of the formula [I], respectively; l.sub.1 and l.sub.2 each are an integer of 2 to 4; l.sub.3 is 2 or 0; l.sub.4 is 0 or 1, provided that l.sub.4 is 0 when l.sub.3 is 2 and l.sub.4 is 1 when l.sub.3 is 0; l.sub.5 is 2 or 3; l.sub.6 is 1 or 2; l.sub.7 is 2 or 3; R.sup.2 is a hydroxyl group or a toluenesulfonyloxy group; and R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each are a hydrogen atom or a lower alkyl group).

摘要翻译： PCT No.PCT / JP85 / 00500 Sec。 371日期：1986年5月2日 102（e）日期1986年5月2日PCT提交1985年9月7日PCT公布。 出版物WO86 / 01798 1986年3月27日。本发明涉及由以下通式[I]表示的新的2-哌嗪基嘧啶衍生物，其可用作例如除草剂活性成分[I]，其中R 1为氢 原子或芳烷基，Y是由以下通式[II]至[VII]表示的基团之一。图像[II] <图像> [III]图像[IV] （VII）其中a和b分别是结合式[I]嘧啶环的位置4和5的位置; l1和l2分别是2至4的整数 l3为2或0; l4为0或1，条件是当l3为2时l4为0，当l3为0时，l4为1; l5为2或3; 16为1或2; 17为2或3; R2 是羟基或甲苯磺酰氧基; R3，R4，R5，R6和R7各自为氢原子或低级烷基）。

公开(公告)号：US4959368A

公开(公告)日：1990-09-25

申请号：US130533

申请日：1987-10-22

申请人： Akira Awaya ,  Takuo Nakano ,  Hisashi Kobayashi ,  Ken E. Tan ,  Kazutoshi Horikomi ,  Tadayuki Sasaki ,  Keiichi Yokoyama ,  Hiroyasu Ohno ,  Kozi Kato ,  Takumi Kitahara ,  Ikuo Tomino ,  Shigeru Isayama

发明人： Akira Awaya ,  Takuo Nakano ,  Hisashi Kobayashi ,  Ken E. Tan ,  Kazutoshi Horikomi ,  Tadayuki Sasaki ,  Keiichi Yokoyama ,  Hiroyasu Ohno ,  Kozi Kato ,  Takumi Kitahara ,  Ikuo Tomino ,  Shigeru Isayama

IPC分类号： A61K31/505 ,  A61K31/506 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/70 ,  C07D239/84 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

CPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/506 ,  C07D239/47 ,  C07D239/48 ,  C07D239/70 ,  C07D239/84 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： A pharmaceutical composition comprising a pyrimidine represented by the following formula ##STR1## wherein R.sup.1 represents a hydrogen atom, an acyl group having 2 to 4 carbon atoms, an alkoxycarbonyl group having 2 to 5 carbon atoms, an alkoxycarbonylmethyl group having 3 to 5 carbon atoms, a 3,4-dimethoxybenzoyl group or a 3,4-methylenedioxybenzyl group,R.sup.2 represents a hydrogen atom, an amino group, a monoalkylamino group having 1 to 4 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an alkoxycarbonyl group having 2 to 4 carbon atoms,R.sup.3 represents a hydrogen atom, an alkoxycarbonyl group having 2 to 4 carbon atoms, a dialkylaminocarbonyl group having 1 to 9 carbon atoms in each alkyl moiety, an alkoxy group having 1 to 5 carbon atoms, or a hydroxyethyl group, R.sup.2 and R.sup.3, together with the carbon atoms to which they are bonded, may form a 5- to 7-membered carbocyclic ring or a heterocyclic ring having N, O or S as the hetero atom, and R.sup.4 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkylthio group having 1 to 4 carbon atoms,or a pharmaceutically acceptable salt thereof. The above active compound has activities of promoting growth of nerve cells, forming neurites, and restoring motor functions, and is useful as an agent for treating diseases of peripheral and central nerves.

公开(公告)号：US5192799A

公开(公告)日：1993-03-09

申请号：US895417

申请日：1992-06-05

申请人： Ikuo Tomino ,  Masaharu Ishiguro ,  Takumi Kitahara ,  Keiichi Yokoyama ,  Noriaki Kihara ,  Joji Kamiya ,  Kanji Yoshihara ,  Masaaki Ishii ,  Akira Mizuchi ,  Kazutoshi Horikomi ,  Akira Awaya ,  Takuo Nakano

发明人： Ikuo Tomino ,  Masaharu Ishiguro ,  Takumi Kitahara ,  Keiichi Yokoyama ,  Noriaki Kihara ,  Joji Kamiya ,  Kanji Yoshihara ,  Masaaki Ishii ,  Akira Mizuchi ,  Kazutoshi Horikomi ,  Akira Awaya ,  Takuo Nakano

IPC分类号： A61K31/34 ,  A61K31/35 ,  C07C217/18 ,  C07C217/22 ,  C07C217/32 ,  C07D209/08 ,  C07D209/48 ,  C07D211/14 ,  C07D215/04 ,  C07D217/02 ,  C07D217/24 ,  C07D235/06 ,  C07D265/36 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/83 ,  C07D307/86 ,  C07D307/91 ,  C07D311/04 ,  C07D311/08 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18 ,  C07D311/20 ,  C07D311/22 ,  C07D311/24 ,  C07D311/58 ,  C07D311/74 ,  C07D317/06 ,  C07D317/46 ,  C07D317/48 ,  C07D327/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D471/10 ,  C07D487/04 ,  C07D487/22 ,  C07D491/10

CPC分类号： C07D209/48 ,  C07C217/18 ,  C07C217/22 ,  C07C217/32 ,  C07D209/08 ,  C07D211/14 ,  C07D215/04 ,  C07D217/02 ,  C07D217/24 ,  C07D235/06 ,  C07D265/36 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/83 ,  C07D307/86 ,  C07D307/91 ,  C07D311/04 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18 ,  C07D311/20 ,  C07D311/22 ,  C07D311/24 ,  C07D311/58 ,  C07D317/46 ,  C07D317/48 ,  C07D327/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D471/10 ,  C07D487/04 ,  C07D491/10 ,  C07C2102/08

摘要： Amine represented by the following formula (1), or their acid addition salts or their quaternary ammonium salts. ##STR1## The amines of formula (1) or their pharmaceutically acceptable acid addition salts or quaternary ammonium salts are useful for the treatment and prevention of heart diseases of animals, particularly arrhythima, myocardial infarction, angina pectoris and heart failure and psychoneurological diseases.

摘要翻译： 由下式（1）表示的胺或其酸加成盐或其季铵盐。 （1）式（1）的胺或其药学上可接受的酸加成盐或季铵盐可用于治疗和预防动物的心脏病，特别是心律不齐，心肌梗塞，心绞痛和心力衰竭以及心理学 疾病

公开(公告)号：US4734418A

公开(公告)日：1988-03-29

申请号：US805905

申请日：1985-12-06

申请人： Keiichi Yokoyama ,  Koji Kato ,  Takumi Kitahara ,  Hiroyasu Ohno ,  Takashi Nishina ,  Mikio Kumakura ,  Akira Awaya ,  Takuo Nakano ,  Kazuyuki Watanabe ,  Sakae Saruta

发明人： Keiichi Yokoyama ,  Koji Kato ,  Takumi Kitahara ,  Hiroyasu Ohno ,  Takashi Nishina ,  Mikio Kumakura ,  Akira Awaya ,  Takuo Nakano ,  Kazuyuki Watanabe ,  Sakae Saruta

IPC分类号： C07D239/95 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  A61K31/55 ,  A61K31/505 ,  C07D401/04 ,  C07D403/14

CPC分类号： C07D401/12 ,  C07D239/95 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： Disclosed herein is an antihypertensive preparation containing, as an active component, a novel quinazoline derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sup.100 means a hydrogen atom or methoxy group, R.sup.200 and R.sup.300 denote individually a hydrogen atom or lower alkoxy group, R.sup.400 is a hydrogen atom or amino group, l stands for 2 or 3, and Het is a specific hetero ring group.

摘要翻译： 本文公开了一种抗高血压制剂，其含有作为活性成分的由以下通式表示的新型喹唑啉衍生物或其盐：其中R100表示​​氢原子或甲氧基，R200和R300分别表示氢原子或 低级烷氧基，R400为氢原子或氨基，l为2或3，Het为特定的杂环基。

公开(公告)号：US4966968A

公开(公告)日：1990-10-30

申请号：US436805

申请日：1989-11-15

申请人： Isao Hashimoto ,  Keiichi Yokoyama ,  Takumi Kitahara

发明人： Isao Hashimoto ,  Keiichi Yokoyama ,  Takumi Kitahara

IPC分类号： C07D265/30 ,  A01N37/42 ,  C07C69/738 ,  C07C235/78 ,  C07D295/185

CPC分类号： C07D295/185 ,  A01N37/42 ,  C07C235/78 ,  C07C2101/08

摘要： Discloses indan derivatives represented by the general formula [1] ##STR1## wherein R is a lower alkoxy group, a phenoxy group, ##STR2## whereupon R.sup.1 and R.sup.2 are, respectively, a hydrogen atom, a lower alkyl, lower alkenyl, phenyl, or phenyl group substituted by halogen atoms, or a monopholino group.The indan derivatives demonstrated satisfactory results in respect of a weeding effect and safety in practical use.

公开(公告)号：US20110073755A1

公开(公告)日：2011-03-31

申请号：US12923444

申请日：2010-09-22

申请人： Keiichi Yokoyama ,  Leo Matsuoka ,  Hiroshi Akagi ,  Tatsuya Kasajima ,  Masaaki Tsubouchi ,  Atsushi Yokoyama

发明人： Keiichi Yokoyama ,  Leo Matsuoka ,  Hiroshi Akagi ,  Tatsuya Kasajima ,  Masaaki Tsubouchi ,  Atsushi Yokoyama

IPC分类号： H01J49/00

CPC分类号： B01D59/34

摘要： Molecules of a specific species can be selectively excited among molecules of a plurality of species that show only a slight difference of mass. Energy levels can be displayed on a graph where the horizontal axis indicates excitation energy. Assume an instance where an electromagnetic wave showing a comb-shaped spectrum having a plurality of narrow bands as indicated by P1 through P14 and tuning with excitation energies corresponding to the rotational levels of molecule X is irradiated onto the molecule X. The molecule X can sequentially make transitions to higher energy levels by using an electromagnetic wave showing such a comb-shaped spectrum. The energy levels of molecule Y are not synchronized with the comb-shaped spectrum. The two ranges of Y4 through Y7 and Y12 through Y15 operate as gates and the molecule Y cannot make transition from a rotational level to another when a gate is found between them.

摘要翻译： 可以在仅显示轻微质量差异的多种物种的分子中选择性地激发特定物种的分子。 能量水平可以显示在横轴表示激发能量的图形上。 假设示出具有如P1至P14所示的多个窄带的梳状光谱的电磁波并且对应于分子X的旋转电平的激发能量的调谐被照射到分子X上。分子X可以顺序地 通过使用显示这样的梳状光谱的电磁波使过渡到更高的能级。 分子Y的能级与梳状光谱不同步。 Y4至Y7和Y12至Y15的两个范围作为门进行操作，并且当在它们之间发现栅极时，分子Y不能从旋转电平转变为另一个。

公开(公告)号：US07252972B2

公开(公告)日：2007-08-07

申请号：US10673860

申请日：2003-09-30

申请人： Yoshimi Kikuchi ,  Masayo Date ,  Yukiko Umezawa ,  Keiichi Yokoyama ,  Haruo Heima ,  Hiroshi Matsui

发明人： Yoshimi Kikuchi ,  Masayo Date ,  Yukiko Umezawa ,  Keiichi Yokoyama ,  Haruo Heima ,  Hiroshi Matsui

IPC分类号： C12P21/04 ,  C12N1/21

CPC分类号： C07K14/36 ,  C07K5/1016 ,  C07K14/195 ,  C07K14/34 ,  C07K2319/00 ,  C12N15/77

摘要： The object of the present invention is to provide a method of producing a heterologous protein by making a coryneform bacterium to produce and efficiently extracellularly secrete (secreto-production) an industrially useful heterologous protein. According to the present invention, a genetic construct is used where a gene sequence encoding an intended protein which is ligated to the downstream of a sequence encoding the signal peptide derived from a coryneform bacterium, the gene construct is introduced into a mutant coryneform bacterium which has a capacity of secreting the heterologous protein at least 2-fold higher than the wild type Corynebacterium glutamicum ATCC 13869, the mutant coryneform bacterium is cultured and the extracellularly released heterologous protein is recovered.

摘要翻译： 本发明的目的是提供通过使棒状细菌产生并有效地细胞外分泌（分泌产生）工业上有用的异源蛋白质来产生异源蛋白质的方法。 根据本发明，使用遗传构建体，其中将编码预期蛋白质的基因序列连接到编码衍生自棒状杆菌型细菌的信号肽的序列的下游，所述基因构建体被引入到突变型棒状杆菌型细菌中 分泌异源蛋白质的能力比野生型谷氨酸棒杆菌ATCC 13869高至少2倍，培养突变棒杆菌型细菌，并回收细胞外释放的异源蛋白质。

公开(公告)号：US20060019367A1

公开(公告)日：2006-01-26

申请号：US11218780

申请日：2005-09-06

申请人： Yukiko Umezawa ,  Keiichi Yokoyama ,  Yoshimi Kikuchi ,  Masayo Date ,  Norimasa Onishi

发明人： Yukiko Umezawa ,  Keiichi Yokoyama ,  Yoshimi Kikuchi ,  Masayo Date ,  Norimasa Onishi

IPC分类号： C12N9/50 ,  C12N9/10 ,  C07H21/04 ,  C12N15/74 ,  C12N1/21

CPC分类号： C12N9/1044 ,  C12N9/6489

摘要： The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral metalloprotease. An active microbial transglutaminase having the pro-structure part cleaved can be obtained by culturing a microorganism into which a gene encoding the neutral metalloprotease from actinomycetes according to the present invention has been introduced, where by producing the neutral metalloprotease from actinomycetes, and reacting it on a microbial protransglutaminase.

摘要翻译： 本发明提供来自放线菌的中性金属蛋白酶，其选择性地切割微生物转谷氨酰胺酶的前体结构部分和编码所述中性金属蛋白酶的基因。 具有前体结构部分切割的活性微生物转谷氨酰胺酶可以通过培养从引入放线菌中产生中性金属蛋白酶的本发明的编码中性金属蛋白酶的基因的微生物获得，其中通过从放线菌产生中性金属蛋白酶， 微生物抗转谷氨酰胺酶。

公开(公告)号：US06180800B2

公开(公告)日：2001-01-30

申请号：US09436259

申请日：1999-11-09

申请人： Keiichi Yokoyama ,  Takako Koiso ,  Akio Hiwara

发明人： Keiichi Yokoyama ,  Takako Koiso ,  Akio Hiwara

IPC分类号： C07D31708

CPC分类号： C07D317/36 ,  H01M6/164 ,  H01M10/052 ,  H01M10/0569 ,  H01M2300/0034

摘要： Monofluoromethyl ethylene carbonate, difluoromethyl ethylene carbonate and trifluoromethyl ethylene carbonate are provided as novel compounds. These compounds are very useful as solvents because they are chemically and physically stable, have a high dielectric constant, can readily dissolve organic substances and have a wide application temperature range. These compounds have excellent charge and discharge cycle characteristics, have a high flash point, and are safe as non-aqueous elecytrolytes. Hence, batteries using these compounds withstand voltage and have excellent charge and discharge cycle characteristics.

摘要翻译： 提供单氟甲基碳酸亚乙酯，二氟甲基碳酸亚乙酯和碳酸三氟甲酯作为新化合物。 这些化合物作为溶剂是非常有用的，因为它们是化学和物理稳定的，具有高介电常数，可以容易地溶解有机物质并具有广泛的应用温度范围。 这些化合物具有优异的充放电循环特性，具有高闪点，并且作为非水溶性电解质是安全的。 因此，使用这些化合物的电池耐受电压并且具有优异的充放电循环特性。

公开(公告)号：US5580684A

公开(公告)日：1996-12-03

申请号：US499393

申请日：1995-07-07

申请人： Keiichi Yokoyama ,  Shigeru Fujita ,  Akio Hiwara ,  Yoshiaki Naruse ,  Masahiro Toriida ,  Atsuo Omaru

发明人： Keiichi Yokoyama ,  Shigeru Fujita ,  Akio Hiwara ,  Yoshiaki Naruse ,  Masahiro Toriida ,  Atsuo Omaru

IPC分类号： H01M6/16 ,  H01M10/052 ,  H01M10/0567 ,  H01M6/14

CPC分类号： H01M10/0567 ,  H01M10/052 ,  H01M6/164

摘要： A non-aqueous electrolytic solutions which has self-distinguishing property, low reactivity to metal lithium and high withstand voltage is provided. The non-aqueous electrolytic solutions of the first invention comprise, as electrolyte, lithium salt preferably LiPF.sub.6 and, as solvent, phosphoric acid esters of the following general formula [1]; ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, represent an alkyl group or an alkyl group substituted by one or more halogen atoms and at least one of R.sup.1, R.sup.2, and R.sup.3 represents an alkyl group substituted by one or more halogen atoms. The non-aqueous electrolytic solutions of the second invention comprise, as solvents for electrolyte, trimethyl phosphate, one or more linear carbonates represented by the following general formula [3]; ##STR2## (wherein R.sup.6 represents methyl or ethyl group and R.sup.7 represents a linear or branched alkyl group having 1 to 3 carbon atoms) and one or more cyclic carbonates and, as electrolyte, LiPF.sub.6 ; wherein content of the trymetyl phosphate is 1 to 10% by volume of the solvents for electrolyte. The non-aqueous electrolytic solution is suitable for a cell using carbon material capable of being doped and dedoped with lithium ions as a negative electrode active material and complexed oxide of lithium and a transition metal as a positive electrode active material.

摘要翻译： 提供了具有自我辨别性，对金属锂的低反应性和高耐受电压的非水电解液。 第一发明的非水电解液包含作为电解质的锂盐，优选LiPF 6和作为溶剂的下列通式[1]的磷酸酯; 其中R 1，R 2和R 3可以相同或不同，表示烷基或被一个或多个卤素原子取代的烷基，并且R 1，R 2和R 3中的至少一个表示烷基 基团被一个或多个卤素原子取代。 第二发明的非水电解液包含作为电解质溶剂的磷酸三甲酯，由以下通式[3]表示的一种或多种直链碳酸酯; [3]（其中R 6表示甲基或乙基，R 7表示碳原子数1〜3的直链或支链烷基）和一种或多种环状碳酸酯，作为电解质，LiPF 6; 其中磷酸三甲酯的含量为电解质溶剂的1〜10体积％。 非水电解液适用于能够掺杂和去掺杂锂离子作为负极活性物质的锂电池和锂和过渡金属的复合氧化物作为正极活性物质的电池。