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1.发明授权Immunoassay method/equipment, biological component measurable toilet, anti-albumin monoclonal antibody, cell strain producing the same, and albumin detection kit 失效免疫测定法/设备，生物成分可测量马桶，抗白蛋白单克隆抗体，产生相同的细胞株和白蛋白检测试剂盒公开(公告)号：US07241578B2
公开(公告)日：2007-07-10
申请号：US10441192
申请日：2003-05-20
IPC分类号： G01K33/53 , G01K33/536 , G01K33/557 , G01K33/577 , C07K16/18 , C12N5/20 , C12P21/08
CPC分类号： A61B5/415 , A61B5/20 , A61B10/0038 , A61B10/007 , C07K16/18 , G01N33/577 , G01N33/68
摘要： The immunoassay method of this invention measures the content of a subject substance in a sample. The method includes the steps of: (a) preparing a mixed solution by mixing the sample and an antibody solution including a first monoclonal antibody and a second monoclonal antibody capable of specifically binding to the subject substance; and (b) measuring an optical property of the mixed solution. The first monoclonal antibody is capable of binding to a first epitope of the subject substance, and the second monoclonal antibody is capable of binding to a second epitope of the subject substance different from the first epitope. Each of the first and second epitopes exists singly in the subject substance.
摘要翻译： 本发明的免疫测定方法测定样品中目标物质的含量。 该方法包括以下步骤：（a）通过混合样品和包含第一单克隆抗体和能够特异性结合本发明物质的第二单克隆抗体的抗体溶液来制备混合溶液; 和（b）测量混合溶液的光学性质。 第一单克隆抗体能够结合受试物质的第一表位，第二单克隆抗体能够结合不同于第一表位的受试物质的第二表位。 第一和第二表位中的每一个单独存在于主题物质中。
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公开(公告)号：US20050009102A1
公开(公告)日：2005-01-13
申请号：US10886640
申请日：2004-07-09
申请人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
发明人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
IPC分类号： G01N21/82 , G01N33/52 , G01N33/53 , G01N33/536 , G01N33/557
CPC分类号： G01N33/557
摘要： According to the present invention, the expansion of measurable concentration range for an antigen in a sample solution can be achieved, without a step of dilution or the like. The concentration of an antigen contained in a sample solution is determined from the maximum value and/or minimum value of turbidity level detected in the observation of the transient phenomenon of turbidity, elapsed time when the maximum and/or minimum value is observed, and turbidity level.
摘要翻译： 根据本发明，可以在没有稀释步骤等的情况下实现样品溶液中的抗原的可测量的浓度范围的扩大。 样品溶液中含有的抗原浓度是根据观察浊度的瞬时现象，观察到最大值和/或最小值时的经过时间以及浊度的最大值和/或最小值来确定的。 水平。
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公开(公告)号：US07202041B2
公开(公告)日：2007-04-10
申请号：US10516067
申请日：2003-12-09
申请人： Akihito Kamei , Tatsurou Kawamura , Keiko Yugawa
发明人： Akihito Kamei , Tatsurou Kawamura , Keiko Yugawa
IPC分类号： G01N33/53 , G01N33/536 , G01N21/00 , C07K16/00
CPC分类号： G01N33/5306 , Y10S435/961 , Y10S436/805
摘要： The present invention relates to an immunoreaction measuring method for measuring an antigen or antibody contained as a subject substance in a sample, wherein the sample was mixed with at least one compound selected from the group consisting of dicarboxylic acids having a hydroxyl group, dicarboxylic acids having a double bond, straight-chain dicarboxylic acids expressed by the chemical formula (1): HOOC(CH2)nCOOH (n is an integer), and the salts of these dicarboxylic acids, and an antibody or antigen as a specifically binding substance capable of specifically binding to the subject substance, to obtain an acidic reaction solution, and then an antigen-antibody complex, generated by an antigen-antibody reaction of the subject substance with the specifically binding substance in the reaction solution was detected. This makes it possible to improve a measurement value and to relax a limitation of a measurement range due to a zone phenomenon that occurs in an antigen-excess region.
摘要翻译： 本发明涉及一种用于测量样品中作为主体物质的抗原或抗体的免疫反应测定方法，其中将样品与选自由具有羟基的二羧酸组成的组中选择的至少一种化合物混合， 双键，由化学式（1）表示的直链二羧酸：HOOC（CH 2 CH 2）n COOH（n为整数），其盐 这些二羧酸和作为特异性结合物质的能够与本发明物质特异性结合的抗体或抗原，获得酸性反应溶液，然后将抗原 - 抗体复合物通过本发明物质的抗原 - 抗体反应与 检测反应溶液中特异性结合物质。 这使得可以改善测量值并且放松由于在抗原过量区域中发生的区域现象引起的测量范围的限制。
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公开(公告)号：US07226777B2
公开(公告)日：2007-06-05
申请号：US10886640
申请日：2004-07-09
申请人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
发明人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
CPC分类号： G01N33/557
摘要： According to the present invention, the expansion of measurable concentration range for an antigen in a sample solution can be achieved, without a step of dilution or the like. The concentration of an antigen contained in a sample solution is determined from the maximum value and/or minimum value of turbidity level detected in the observation of the transient phenomenon of turbidity, elapsed time when the maximum and/or minimum value is observed, and turbidity level.
摘要翻译： 根据本发明，可以在没有稀释步骤等的情况下实现样品溶液中的抗原的可测量的浓度范围的扩大。 样品溶液中含有的抗原浓度是根据观察浊度的瞬时现象，观察到最大值和/或最小值时的经过时间以及浊度的最大值和/或最小值来确定的。 水平。
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公开(公告)号：US20060281195A1
公开(公告)日：2006-12-14
申请号：US11507011
申请日：2006-08-21
IPC分类号： C12M1/34 , G01N33/551
CPC分类号： G01N33/53 , G01N33/54333
摘要： A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the sample and a magnetic particle on which a specific coupling substance for specifically coupling with the subject substance is immobilized; (b) measuring an optical characteristic of the reaction system; and (c) removing, from the reaction system, an agglutination complex including the subject substance, the specific coupling substance and the magnetic particle by utilizing magnetic force.
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公开(公告)号：US07553676B2
公开(公告)日：2009-06-30
申请号：US11507011
申请日：2006-08-21
IPC分类号： G01N33/553
CPC分类号： G01N33/53 , G01N33/54333
摘要： A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the sample and a magnetic particle on which a specific coupling substance for specifically coupling with the subject substance is immobilized; (b) measuring an optical characteristic of the reaction system; and (c) removing, from the reaction system, an agglutination complex including the subject substance, the specific coupling substance and the magnetic particle by utilizing magnetic force.
摘要翻译： 本发明的用于测量样品中目标物质含量的特定偶合反应测量方法包括以下步骤：（a）构建包含样品和磁性颗粒的反应体系，其上特异性偶联物质与该物质偶合 物质被固定; （b）测量反应体系的光学特性; 和（c）通过利用磁力从反应体系中除去包含被检体，特定偶联物质和磁性粒子的凝集络合物。
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公开(公告)号：US20050176063A1
公开(公告)日：2005-08-11
申请号：US10516067
申请日：2003-12-09
申请人： Akihito Kamei , Tatsurou Kawamura , Keiko Yugawa
发明人： Akihito Kamei , Tatsurou Kawamura , Keiko Yugawa
IPC分类号： G01N33/53 , G01N33/531
CPC分类号： G01N33/5306 , Y10S435/961 , Y10S436/805
摘要： The present invention relates to an immunoreaction measuring method for measuring an antigen or antibody contained as a subject substance in a sample, wherein the sample was mixed with at least one compound selected from the group consisting of dicarboxylic acids having a hydroxyl group, dicarboxylic acids having a double bond, straight-chain dicarboxylic acids expressed by the chemical formula (1): HOOC(CH2)nCOOH (n is an integer), and the salts of these dicarboxylic acids, and an antibody or antigen as a specifically binding substance capable of specifically binding to the subject substance, to obtain an acidic reaction solution, and then an antigen-antibody complex, generated by an antigen-antibody reaction of the subject substance with the specifically binding substance in the reaction solution was detected. This makes it possible to improve a measurement value and to relax a limitation of a measurement range due to a zone phenomenon that occurs in an antigen-excess region.
摘要翻译： 本发明涉及一种用于测量样品中作为主体物质的抗原或抗体的免疫反应测定方法，其中将样品与选自由具有羟基的二羧酸组成的组中选择的至少一种化合物混合， 双键，由化学式（1）表示的直链二羧酸：HOOC（CH 2 CH 2）n COOH（n为整数），其盐 这些二羧酸和作为特异性结合物质的能够与本发明物质特异性结合的抗体或抗原，获得酸性反应溶液，然后将抗原 - 抗体复合物通过本发明物质的抗原 - 抗体反应与 检测反应溶液中特异性结合物质。 这使得可以改善测量值并且放松由于在抗原过量区域中发生的区域现象引起的测量范围的限制。
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8.发明授权Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same 有权特异性偶联反应测定方法及试剂盒及特异性偶联反应测定装置用于其中公开(公告)号：US07105359B2
公开(公告)日：2006-09-12
申请号：US10704802
申请日：2003-11-12
IPC分类号： G01N33/553
CPC分类号： G01N33/53 , G01N33/54333
摘要： A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the sample and a magnetic particle on which a specific coupling substance for specifically coupling with the subject substance is immobilized; (b) measuring an optical characteristic of the reaction system; and (c) removing, from the reaction system, an agglutination complex including the subject substance, the specific coupling substance and the magnetic particle by utilizing magnetic force.
摘要翻译： 本发明的用于测量样品中目标物质含量的特定偶合反应测量方法包括以下步骤：（a）构建包含样品和磁性颗粒的反应体系，其上特异性偶联物质与该物质偶联 物质被固定; （b）测量反应体系的光学特性; 和（c）通过利用磁力从反应体系中除去包含被检体，特定偶联物质和磁性粒子的凝集络合物。
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公开(公告)号：US20050228242A1
公开(公告)日：2005-10-13
申请号：US11095543
申请日：2005-04-01
CPC分类号： A61B5/00 , A61B5/6887 , A61B5/7275 , G16H50/20 , G16H50/30
摘要： A vital data utilization system that stores and utilizes measured vital data, including: a vital data measurement unit 101 that measures the vital data of a subject; a time measurement unit 102 that stores the information on the measurement date and time at which the vital data was measured; a subject information storage unit 103 on which subject information including the vital data and the information on the measurement date and time that are associated with each other are stored; a reference information storage unit 104 on which reference information including the vital data and the information on the measurement date and time are stored; a subject variation pattern generation unit that extracts, from the subject information storage unit, the subject information in a specific period that lasts until the vital data that satisfies a first predetermined condition is measured, in the case of the measured vital data satisfies the first predetermined condition; a reference variation pattern generation unit 116 that extracts, from the reference information storage unit, the vital data that satisfies the first predetermined condition, extracts, from the reference information storage unit, the reference information in the specific period that lasts until the vital data is measured, and generate a reference variation pattern, and a prediction variation pattern generation unit 105 that generates a prediction variation pattern using the reference information after this reference variation pattern, in the case where the comparison result of the reference variation pattern and the subject variation pattern satisfies the second predetermined condition.
摘要翻译： 一种重要的数据利用系统，其存储和利用测量的重要数据，包括：测量对象的重要数据的重要数据测量单元101; 时间测量单元102，其存储关于测量生命数据的测量日期和时间的信息; 主题信息存储单元103，其上存储包括重要数据的对象信息和关于彼此关联的测量日期和时间的信息; 参考信息存储单元104，其上存储包括重要数据的参考信息和关于测量日期和时间的信息; 被摄体变化图案生成单元，从被检体信息存储单元取出在所测量的生命体数据满足第1规定条件的情况下，持续到持续至满足第1规定条件的重要数据为止的特定期间的被检体信息 条件; 从参考信息存储单元提取满足第一预定条件的重要数据的参考变化模式生成单元116从参考信息存储单元中提取持续到生命数据的特定时段内的参考信息 测量并产生参考变化模式;以及预测变化模式生成单元105，其在参考变化模式和对象变化模式的比较结果的情况下，使用参考变化模式之后的参考信息生成预测变化模式 满足第二预定条件。
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公开(公告)号：US07790470B2
公开(公告)日：2010-09-07
申请号：US10588546
申请日：2005-03-23
CPC分类号： B01F5/0057 , B01F1/0022 , B01F5/0206 , B01F2215/0037 , G01N21/03 , G01N21/76 , G01N2035/00544 , Y10T436/25
摘要： A method capable of stirring a liquid sample and a reagent promptly and easily includes the following steps (A) and (B). In step (A), using a cell including: a liquid sample retaining section having a plurality of particles; and a liquid sample supply inlet, a liquid sample containing an analyte is supplied from the liquid sample supply inlet to the liquid sample retaining section. In step (B), the liquid sample and a specific binding substance capable of specifically binding to the analyte are stirred by the movement of the particles caused by the flow of the liquid sample in the cell resulting from the supply of the liquid sample, to obtain a liquid mixture. The electric charge of at least the surface of the particles and the electric charge of the specific binding substance have the same polarity in the liquid mixture.
摘要翻译： 能够迅速且容易地搅拌液体样品和试剂的方法包括以下步骤（A）和（B）。 在步骤（A）中，使用包括：具有多个颗粒的液体样品保留部分的细胞; 将液体试样供给口从液体试样供给口供给到液体试样保持部。 在步骤（B）中，液体样品和能够特异性结合分析物的特异性结合物质由于由液体样品供应而导致的液体样品流动引起的颗粒运动而被搅拌至 获得液体混合物。 至少颗粒表面的电荷和特定结合物质的电荷在液体混合物中具有相同的极性。
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