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    Glucose sensor
    1.
    发明授权
    Glucose sensor 有权
    葡萄糖传感器

    公开(公告)号：US06773564B1

    公开(公告)日：2004-08-10

    申请号：US09406832

    申请日：1999-09-28

    申请人： Keiko Yugawa ,  Toshihiko Yoshioka ,  Shiro Nankai ,  Junko Iwata ,  Shoji Miyazaki ,  Hideyuki Baba ,  Seiji Takeshima

    发明人： Keiko Yugawa ,  Toshihiko Yoshioka ,  Shiro Nankai ,  Junko Iwata ,  Shoji Miyazaki ,  Hideyuki Baba ,  Seiji Takeshima

    IPC分类号： G01N27327

    CPC分类号： C12Q1/006

    摘要： The present invention provides a high performance glucose sensor which can demonstrate high stability against preservation and produces only a low blank value. The glucose sensor comprises an electrically insulating base plate, an electrode system formed on the base plate, and a reaction layer which is formed in contact with or in the vicinity of the electrode system and contains at least a glucose dehydrogenase whose coenzyme is pyrrolo-quinoline quinone, the reaction layer further containing an additive such as phthalic acid.

    摘要翻译： 本发明提供了一种高性能葡萄糖传感器，其可以显示对保存的高稳定性并且仅产生低的空白值。 葡萄糖传感器包括电绝缘基板，形成在基板上的电极系统和与电极系统接触或附近形成的反应层，并且至少含有辅酶是吡咯并喹啉的葡萄糖脱氢酶 醌，反应层还含有邻苯二甲酸等添加剂。

    Glucose sensor
    2.
    发明授权
    Glucose sensor 有权
    葡萄糖传感器

    公开(公告)号：US07005048B1

    公开(公告)日：2006-02-28

    申请号：US09807692

    申请日：2000-10-02

    申请人： Motokazu Watanabe ,  Keiko Yugawa ,  Toshihiko Yoshioka ,  Shiro Nankai ,  Junko Nakayama ,  Shoji Miyazaki ,  Hideyuki Baba

    发明人： Motokazu Watanabe ,  Keiko Yugawa ,  Toshihiko Yoshioka ,  Shiro Nankai ,  Junko Nakayama ,  Shoji Miyazaki ,  Hideyuki Baba

    IPC分类号： G01N27/327

    CPC分类号： C12Q1/006

    摘要： The present invention provides a high-performance glucose sensor having excellent storage stability and an improved response characteristic. This sensor comprises: an electrically insulating base plate; an electrode system including at least a working electrode and a counter electrode formed on the base plate; and a reaction layer containing at least pyrrolo-quinoline quinone dependent glucose dehydrogenase, formed in contact with or in the vicinity of the electrode system, and the reaction layer contains at least one kind of additive selected from the group consisting of gluconic acid and salts thereof.

    摘要翻译： 本发明提供一种具有优异的储存稳定性和改善的响应特性的高性能葡萄糖传感器。 该传感器包括：电绝缘基板; 电极系统，其至少包括形成在所述基板上的工作电极和对电极; 和至少含有与电极体系接触或附近形成的吡咯并喹啉醌依赖型葡萄糖脱氢酶的反应层，反应层含有选自葡萄糖酸及其盐的至少一种添加剂 。

    Biosensor
    3.
    发明授权
    Biosensor 失效
    生物传感器

    公开(公告)号：US5512159A

    公开(公告)日：1996-04-30

    申请号：US293131

    申请日：1994-08-19

    申请人： Toshihiko Yoshioka ,  Mariko Kawaguri ,  Shiro Nankai ,  Haruhiro Tsutsumi ,  Hideyuki Baba ,  Yoshinobu Tokuno ,  Shoji Miyazaki

    发明人： Toshihiko Yoshioka ,  Mariko Kawaguri ,  Shiro Nankai ,  Haruhiro Tsutsumi ,  Hideyuki Baba ,  Yoshinobu Tokuno ,  Shoji Miyazaki

    IPC分类号： G01N27/28 ,  C12M1/34 ,  C12M1/40 ,  C12Q1/00 ,  C12Q1/54 ,  G01N27/327 ,  G01N33/483

    CPC分类号： C12Q1/001

    摘要： A biosensor of the present invention is provided with an insulating base plate, an electrode system mainly consisting of a working electrode and a counter electrode formed on the insulating base plate, and a reaction layer on the electrode system. The counter electrode is partially a circular arc. A manufacturing method of the biosensor of the present invention is comprised of a step to form a base by arranging leads, an electrode system, and an insulating layer on an insulating base plate, and a step to form a reaction layer mainly composed of an enzyme on the electrode system. Since the counter electrode is partially in the shape of a circular arc, the reaction layer is easily formed and prevented from delaminating, whereby the measuring accuracy, preservative properties and reliability of the biosensor are improved. The present invention enables highly efficient biosensors to be mass produced at low cost.

    摘要翻译： 本发明的生物传感器设置有绝缘基板，主要由在绝缘基板上形成的工作电极和对电极组成的电极系统和电极系统上的反应层。 对电极部分是圆弧。 本发明的生物传感器的制造方法包括通过在绝缘基板上排列引线，电极系统和绝缘层形成基底的步骤，以及形成主要由酶组成的反应层的步骤 在电极系统上。 由于对电极部分为圆弧形状，反应层易于形成并防止分层，从而提高了生物传感器的测量精度，防腐性能和可靠性。 本发明能够以低成本批量生产高效生物传感器。

    Sample discriminating method
    4.
    发明授权
    Sample discriminating method 有权
    样本识别方法

    公开(公告)号：US07122111B2

    公开(公告)日：2006-10-17

    申请号：US10878536

    申请日：2004-06-29

    申请人： Hiroyuki Tokunaga ,  Shoji Miyazaki ,  Hideyuki Baba ,  Yoichi Inoue ,  Kazuo Iketaki ,  Katsumi Hamamoto

    发明人： Hiroyuki Tokunaga ,  Shoji Miyazaki ,  Hideyuki Baba ,  Yoichi Inoue ,  Kazuo Iketaki ,  Katsumi Hamamoto

    IPC分类号： G01N27/327 ,  G01N33/48 ,  G01N31/00

    CPC分类号： G01N27/3274 ,  Y10T436/11

    摘要： A glucose sensor system comprising the steps of using as a sample discriminating parameter a ratio (I/ΔI) of a measured current value I to the time-differential value of the current value ΔI, defining a discrimination function that discriminates whether a sample is blood or control fluid and uses the discriminating parameter as an independent variable, quantitating as a discriminating index a numeric value obtained by substituting a discriminating parameter value into this discrimination function, and automatically discriminating, based on this index, whether the sample is blood or a control fluid, whereby a kind of the sample can be automatically quantitated by measuring electric current when a sensor system is used for quantitating the concentration of an analysis object in the sample.

    摘要翻译： 一种葡萄糖传感器系统，包括以下步骤：将测量电流值I与当前值ΔI的时间微分值的比值（I / DeltaI）用作样本鉴别参数，所述差分值定义了鉴别样品是否为血液的鉴别功能 或控制流体，并将鉴别参数用作独立变量，作为鉴别指标，将通过将鉴别参数值代入该鉴别函数而获得的数值，并根据该指标自动鉴别样品是血液还是控制 流体，从而当使用传感器系统来定量样品中的分析对象的浓度时，可以通过测量电流来自动量化样品的种类。

    Sample discriminating method
    5.
    发明授权
    Sample discriminating method 有权
    样本识别方法

    公开(公告)号：US06824670B2

    公开(公告)日：2004-11-30

    申请号：US09890097

    申请日：2001-10-29

    申请人： Hiroyuki Tokunaga ,  Shoji Miyazaki ,  Hideyuki Baba ,  Yoichi Inoue ,  Kazuo Iketaki ,  Katsumi Hamamoto

    发明人： Hiroyuki Tokunaga ,  Shoji Miyazaki ,  Hideyuki Baba ,  Yoichi Inoue ,  Kazuo Iketaki ,  Katsumi Hamamoto

    IPC分类号： G01N2726

    CPC分类号： G01N27/3274 ,  Y10T436/11

    摘要： A glucose sensor system comprising the steps of using as a sample discriminating parameter a ratio (I/&Dgr;I) of a measured current value I to the time-differential value of the current value &Dgr;I, defining a discrimination function that discriminates whether a sample is blood or control fluid and uses the discriminating parameter as an independent variable, quantitating as a discriminating index a numeric value obtained by substituting a discriminating parameter value into this discrimination function, and automatically discriminating, based on this index, whether the sample is blood or a control fluid, whereby a kind of the sample can be automatically quantitated by measuring electric current when a sensor system is used for quantitating the concentration of an analysis object in the sample.

    摘要翻译： 一种葡萄糖传感器系统，包括以下步骤：将测量电流值I与当前值ΔI的时间微分值的比值（I / DeltaI）用作样本鉴别参数，所述差分值定义了鉴别样品是否为血液的鉴别功能 或控制流体，并将鉴别参数用作独立变量，作为鉴别指标，将通过将鉴别参数值代入该鉴别函数而获得的数值，并根据该指标自动鉴别样品是血液还是控制 流体，从而当使用传感器系统来定量样品中的分析对象的浓度时，可以通过测量电流来自动量化样品的种类。

    BIOSENSOR, MEASURING INSTRUMENT FOR BIOSENSOR, AND METHOD OF QUANTIFYING SUBSTRATE
    6.
    发明申请
    BIOSENSOR, MEASURING INSTRUMENT FOR BIOSENSOR, AND METHOD OF QUANTIFYING SUBSTRATE 有权
    生物传感器，生物传感器的测量仪器和定量基板的方法

    公开(公告)号：US20140144791A1

    公开(公告)日：2014-05-29

    申请号：US14166956

    申请日：2014-01-29

    申请人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Yoshinobu Tokuno

    发明人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Yoshinobu Tokuno

    IPC分类号： G01N27/327

    CPC分类号： G01N27/327 ,  A61B5/1486 ,  A61B2562/0295 ,  C12Q1/001 ,  C12Q1/005 ,  C12Q1/006 ,  G01N27/26 ,  G01N27/3272 ,  G01N27/3274 ,  G01N33/48771 ,  G01N33/5438

    摘要： A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltages to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.

    摘要翻译： 提供了测量样品液体中所含的基板的量的方法。 该方法可以减少由生物传感器引起的测量误差。 生物传感器至少包括绝缘板上的一对电极，插入到测量装置中，该测量装置包括用于可拆卸地支撑生物传感器的支撑部分，要耦合到各个电极的多个连接端子和施加一个电极的驱动电源 通过连接端子对各个电极施加电压。 只有当生物传感器沿给定方向插入到测量装置中时，生物传感器的电极之一才连接到测量装置的第一和第二连接端子，并且具有使得电极在第一和第二连接之间变得导电的结构 由于驱动电源施加的电压引起的端子。

    WIRE WITH EXCELLENT SUITABILITY FOR DRAWING AND PROCESS FOR PRODUCING THE SAME
    10.
    发明申请
    WIRE WITH EXCELLENT SUITABILITY FOR DRAWING AND PROCESS FOR PRODUCING THE SAME 有权
    具有优异的适用性的线条及其制造方法

    公开(公告)号：US20090007998A1

    公开(公告)日：2009-01-08

    申请号：US12279000

    申请日：2006-11-07

    申请人： Takuya Kochi ,  Shogo Murakami ,  Shoji Miyazaki ,  Ken Ishida ,  Masao Toyama ,  Fujio Koizumi

    发明人： Takuya Kochi ,  Shogo Murakami ,  Shoji Miyazaki ,  Ken Ishida ,  Masao Toyama ,  Fujio Koizumi

    IPC分类号： C21D9/52 ,  C22C38/34 ,  C22C38/20 ,  C22C38/22 ,  C22C38/32

    CPC分类号： C21D3/06 ,  B21B1/16 ,  B21B3/00 ,  C21D8/065 ,  C21D9/525 ,  C22C38/002 ,  C22C38/04 ,  C22C38/20 ,  C22C38/28 ,  C22C38/34 ,  C22C38/42 ,  C22C38/50

    摘要： A hot-rolled wire rod excelling in wire drawability is provided, in which breakage can be suppressed even in heavy work from a large diameter. A hot-rolled wire rod contains C: 0.35 to 0.65% (percent by mass, hereinafter expressed as well), Si: 1.4 to 3.0%, Mn: 0.10 to 1.0%, Cr: 0.1 to 2.0%, P: 0.025% or less (exclusive of 0%), S: 0.025% or less (exclusive of 0%), N: 0.006% or less (exclusive of 0%), Al: 0.1% or less (exclusive of 0%), and O: 0.0030% or less (exclusive of 0%), with the remnant consisting of Fe and inevitable impurities; wherein the content of hydrogen in steel is 2.50 ppm (ppm by mass, hereinafter expressed as well) or less, and hardness (HV) is 460×C00.1 or less (C0 indicates the content of C (percent by mass) in a position of depth of D/4 (D: diameter of the wire rod)).

    摘要翻译： 提供了一种具有良好的拉丝性的热轧线材，其中即使在大直径的重工作中也能够抑制破损。 热轧线材含有C：0.35〜0.65％（质量％，以下也表示），Si：1.4〜3.0％，Mn：0.10〜1.0％，Cr：0.1〜2.0％，P：0.025％ 较少（不含0％），S：0.025％以下（不含0％），N：0.006％以下（不含0％），Al：0.1％以下（不含0％），O： 0.0030％以下（不含0％），残留物由Fe和不可避免的杂质组成; 钢中的氢含量为2.50ppm（质量ppm，以下也表示）以下，硬度（HV）为460×0.001以下（C0表示C（质量％）的含量 深度D / 4（D：线材直径））。