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公开(公告)号：US5366896A
公开(公告)日：1994-11-22
申请号：US739204
申请日：1991-07-30
申请人： Keith S. Margrey , Robin A. Felder , James C. Boyd , J. William Holman , Jonathan H. Roberts , John Savory , Antonia Martinez
发明人： Keith S. Margrey , Robin A. Felder , James C. Boyd , J. William Holman , Jonathan H. Roberts , John Savory , Antonia Martinez
CPC分类号： G01N35/00871 , G01N35/0099 , G06F19/3406 , G06F19/366 , G01N2035/00752 , G01N2035/00881 , G01N2035/0405 , G01N2035/0491 , G06F19/322 , G06F19/3412 , G06F19/3418 , Y10S436/807 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/12
摘要： The present invention relates to an integrated analytical system which includes a plurality of remote laboratories and a central monitoring station. The remote laboratories include a specimen analysis member and a plurality of peripheral devices. The central monitoring station includes a computer for controlling predetermined functions of the peripheral devices. A local area network provides communication between each of the remote laboratories and the central monitoring station. A computer interface provides bi-directional communication between analytical instruments, robots and peripheral devices and a computer. The system employs a robot which is responsive to computer commands and capable of performing mechanical functions.The mechanical functions include manipulating an analytical instrument, transporting the specimens to be analyzed through a variety of locations, and the manipulation of the container in which the specimen is housed.
摘要翻译： 本发明涉及一种综合分析系统，其包括多个远程实验室和中央监测站。 远程实验室包括样本分析构件和多个外围设备。 中央监控站包括用于控制外围设备的预定功能的计算机。 局域网提供每个远程实验室和中央监测站之间的通信。 计算机接口提供分析仪器，机器人和外围设备以及计算机之间的双向通信。 该系统采用响应于计算机命令并能够执行机械功能的机器人。 机械功能包括操纵分析仪器，通过各种位置运输要分析的样品，以及对容器进行操作。
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公开(公告)号：US5631844A
公开(公告)日：1997-05-20
申请号：US343773
申请日：1994-11-22
CPC分类号： G01N35/00871 , G01N35/0099 , G06F19/3406 , G06F19/366 , G01N2035/00752 , G01N2035/00881 , G01N2035/0405 , G01N2035/0491 , G06F19/322 , G06F19/3412 , G06F19/3418 , Y10S436/807 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/12
摘要： An interactive multi-station medical specimen analysis system for simultaneously analyzing a medical specimen at remote locations and accessing, for evaluation, the results of each of the analyses at a central laboratory is disclosed. The system comprises a server for storing databases. A central laboratory, interacts with the dedicated computers through the server to review, evaluate and either accept or reject specimen analyses. Communication means connect the server with the plurality of dedicated computers, laboratory computer and a centralized mainframe. Analytical instrument to dedicated computer interface software interprets the instrument language into the computer program language and the computer program language into the instrument language. Dedicated computer interactive means request analytical tests, transmit the test results to the server databases and receive and display data from the server databases. Laboratory computer interactive means acquire and display test results from the server databases, review and accept or reject the test results and transmit the acceptance or rejection to the server databases.
摘要翻译： 公开了一种交互式多工位医疗标本分析系统，用于在远程位置同时分析医疗样本，并访问中央实验室进行每次分析的结果进行评估。 该系统包括用于存储数据库的服务器。 中央实验室通过服务器与专用计算机进行交互，以审查，评估并接受或拒绝标本分析。 通信意味着将服务器与多台专用计算机，实验室计算机和集中式主机连接起来。 专用计算机界面软件的分析仪器将仪器语言解释为计算机程序语言和计算机程序语言为仪器语言。 专用计算机交互意味着请求分析测试，将测试结果传输到服务器数据库，并从服务器数据库接收和显示数据。 实验室计算机交互式意味着从服务器数据库获取并显示测试结果，查看并接受或拒绝测试结果，并将接受或拒绝传送到服务器数据库。
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公开(公告)号：US06192320B1
公开(公告)日：2001-02-20
申请号：US09532286
申请日：2000-03-23
IPC分类号： G01N3300
CPC分类号： G01N35/00871 , G06F19/00 , G16H10/40 , G16H40/40 , Y10T436/11
摘要： An interactive multi-station medical specimen analysis system for simultaneously analyzing a medical specimen at remote locations and accessing, for evaluation, the results of each of the analyses at a central laboratory is disclosed. A central laboratory, interacts with remote computers, through a server to review, evaluate and accept or reject specimen analyses. The server communicates with the plurality of remote computers, laboratory computer and a centralized computer via a network. Analytical instruments which are not equipped to communicate with a computer are connected through computer interface software which interprets the instrument language into the computer program language and the computer program language into the instrument language. The interactive system requests analytical tests, transmits the test results to the server databases and receives and displays data from the server databases. Laboratory based interactive software acquires and either displays test results from the server databases, reviews and accepts or rejects the test results and transmits the acceptance or rejection to the server databases.
摘要翻译： 公开了一种交互式多工位医疗标本分析系统，用于在远程位置同时分析医疗样本，并访问中央实验室进行每次分析的结果进行评估。 中央实验室通过服务器与远程计算机进行交互，以审查，评估和接受或拒绝标本分析。 服务器通过网络与多个远程计算机，实验室计算机和集中式计算机进行通信。 未配备与计算机进行通信的分析仪器通过计算机界面软件进行连接，该软件将仪器语言解释为计算机程序语言和计算机程序语言为仪器语言。 交互式系统请求分析测试，将测试结果发送到服务器数据库，并从服务器数据库接收和显示数据。 基于实验室的交互式软件获取并显示来自服务器数据库的测试结果，评估并接受或拒绝测试结果，并将接受或拒绝传送到服务器数据库。
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公开(公告)号：US6055487A
公开(公告)日：2000-04-25
申请号：US859240
申请日：1997-05-20
CPC分类号： G01N35/00871 , G01N35/00594 , G06F19/3418 , G01N2035/00881 , Y10T436/11
摘要： An bi-directional, interactive multi-station medical specimen analysis system for simultaneously analyzing a medical specimen at remote locations and accessing, for evaluation, the results of each of the analyses at a central laboratory is disclosed. The system is networked to a server for storing databases. A central laboratory, interacts with remote computers, through the server to review, evaluate and accept or reject specimen analyses. The server communicates with the plurality of dedicated computers, laboratory computer and a centralized computer through a LAN or WAN. Analytical instruments which are not equipped to communicate with a computer are connected through computer interface software which interprets the instrument language into the computer program language and the computer program language into the instrument language. The bi-directional, interactive system requests analytical tests, transmit the test results to the server databases and receives and displays data from the server databases. Laboratory based bi-directional, interactive software acquires and either displays test results from the server databases, reviews and accepts or rejects the test results and transmits the acceptance or rejection to the server databases.
摘要翻译： 公开了一种双向交互式多工位医疗样本分析系统，用于同时分析偏远地区的医疗样本，并访问中央实验室进行每次分析的结果进行评估。 该系统联网到用于存储数据库的服务器。 中心实验室通过服务器与远程计算机进行交互，以审查，评估和接受或拒绝标本分析。 服务器通过LAN或WAN与多台专用计算机，实验室计算机和集中式计算机进行通信。 未配备与计算机进行通信的分析仪器通过计算机界面软件进行连接，该软件将仪器语言解释为计算机程序语言和计算机程序语言为仪器语言。 双向互动系统请求分析测试，将测试结果发送到服务器数据库，并从服务器数据库接收和显示数据。 基于实验室的双向交互式软件获取并显示来自服务器数据库的测试结果，评估并接受或拒绝测试结果，并将接受或拒绝传送到服务器数据库。
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5.发明授权公开(公告)号：US08894576B2
公开(公告)日：2014-11-25
申请号：US11076604
申请日：2005-03-10
申请人： Majd Alwan , Robin A. Felder , Steven W. Kell , Sarah G. Wood , Michael Cvetanovich , Beverly L. Turner , J. William Holman
发明人： Majd Alwan , Robin A. Felder , Steven W. Kell , Sarah G. Wood , Michael Cvetanovich , Beverly L. Turner , J. William Holman
IPC分类号： A61B5/00 , G06F15/177 , G06F15/173 , A61B5/11
CPC分类号： A61B5/1115 , A61B5/0002 , A61B5/1112 , A61B5/1113 , A61B5/1116 , A61B5/202 , A61B5/6887 , A61B5/6889 , A61B5/7282 , A61B2560/0242 , A61B2562/0247 , A61B2562/046
摘要： A method and related system to, among other things, automatically infer answers to all of the ADL questions and the first four questions of the IADL in the home. The inference methods detect the relevant activities unobtrusively, continuously, accurately, objectively, quantifiably and without relying on the patient's own memory (which may be fading due to aging or an existing health condition, such as Traumatic Brain Injury (TBI)) or on a caregiver's subjective report. The methods rely on the judicious placement of a number of sensors in the subject's place of residence, including motion detection sensors in every room, the decomposition of each relevant activity into the sub-tasks involved, identification of additional sensors required to detect the relevant sub-tasks and spatial-temporal conditions between the signals of sensors to formulate the rules that will detect the occurrence of the specific activities of interest.
摘要翻译： 一种方法和相关系统，除其他外，自动推断出所有ADL问题和家庭中IADL的前四个问题的答案。 推理方法不间断地，连续地，准确地，客观地，可量化地检测相关活动，而不依赖于患者自己的记忆（可能由于老化或现有健康状况（例如创伤性脑损伤（TBI））而衰退） 看护者的主观报告。 这些方法依赖于在主体居住地点中明智地放置多个传感器，包括每个房间中的运动检测传感器，将每个相关活动分解为所涉及的子任务，识别检测相关子站所需的附加传感器 传感器信号之间的空间和空间 - 时间条件，以制定将检测感兴趣的具体活动的发生的规则。
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公开(公告)号：US06581395B2
公开(公告)日：2003-06-24
申请号：US10263910
申请日：2002-10-03
IPC分类号： F25D1700
CPC分类号： G01N35/028 , F25B2500/06 , F25D11/04 , F25D25/00 , F25D29/001 , G01N1/42 , G01N2035/00752 , G01N2035/0425
摘要： An automated cold storage apparatus, and related method thereof, provides a sample process management system that is a revolutionary approach to the storage and retrieval regarding critical samples. The system—a significant technological breakthrough in laboratory automation—is the first ultra low temperature robotic system capable of being validated. Samples in containers are stored and retrieved robotically through an airlock climate-control chamber that is automatically dehumidified by a dry gas purge, such as a carbon dioxide or nitrogen purge or the like. This purge rapidly reduces ambient humidity to a desirable relative humidity (RH), e.g., less than about 15% RH, virtually eliminating the accumulation of frost. Microplates are systematically identified using barcode technology, for example. Once through the climate-controlled chamber, the containers (i.e., samples) are robotically transferred to the rotary mechanism. This mechanism transports the containers to a derived nest location upon the storage means, such as a carousel or to one of the stationary addresses.
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公开(公告)号：US06688123B2
公开(公告)日：2004-02-10
申请号：US10429490
申请日：2003-05-05
IPC分类号： F25D1700
CPC分类号： G01N35/028 , F25B2500/06 , F25D11/04 , F25D25/00 , F25D29/001 , G01N1/42 , G01N2035/00752 , G01N2035/0425
摘要： An automated cold storage apparatus, and related method thereof, provides a sample process management system that is a revolutionary approach to the storage and retrieval regarding critical samples. The system—a significant technological breakthrough in laboratory automation—is the first ultra low temperature robotic system capable of being validated. Samples in containers are stored and retrieved robotically through an airlock climate-control chamber that is automatically dehumidified by a dry gas purge, such as a carbon dioxide or nitrogen purge or the like. This purge rapidly reduces ambient humidity to a desirable relative humidity (RH), e.g., less than about 15% RH, virtually eliminating the accumulation of frost. Microplates are systematically identified using barcode technology, for example. Once through the climate-controlled chamber, the containers (i.e., samples) are robotically transferred to the rotary mechanism. This mechanism transports the containers to a derived nest location upon the storage means, such as a carousel or to one of the stationary addresses.
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8.发明授权Automated storage and retrieval apparatus for freezers and related method thereof 有权冷冻机自动储存和检索装置及其相关方法公开(公告)号：US06467285B2
公开(公告)日：2002-10-22
申请号：US09935488
申请日：2001-08-23
IPC分类号： F25D1700
CPC分类号： G01N35/028 , F25B2500/06 , F25D11/04 , F25D25/00 , F25D29/001 , G01N1/42 , G01N2035/00752 , G01N2035/0425
摘要： An automated cold storage apparatus, and related method thereof, provides a sample process management system that is a revolutionary approach to the storage and retrieval regarding critical samples. The system—a significant technological breakthrough in laboratory automation—is the first ultra low temperature robotic system capable of being validated. Samples in containers are stored and retrieved robotically through an airlock climate-control chamber that is automatically dehumidified by a dry gas purge, such as a carbon dioxide or nitrogen purge or the like. This purge rapidly reduces ambient humidity to a desirable relative humidity (RH), e.g., less than about 15% RH, virtually eliminating the accumulation of frost. Microplates are systematically identified using barcode technology, for example. Once through the climate-controlled chamber, the containers (i.e., samples) are robotically transferred to the rotary mechanism. This mechanism transports the containers to a derived nest location upon the storage means, such as a carousel or to one of the stationary addresses.
摘要翻译： 一种自动冷藏设备及其相关方法提供了一种样品过程管理系统，其是关于关键样品的存储和检索的革命性方法。 该系统是实验室自动化方面的重大技术突破 - 是能够验证的第一台超低温机器人系统。 容器中的样品通过气闸气候控制室被机器人储存和回收，该空气调节室通过干燥气体吹扫（例如二氧化碳或氮气吹扫等）自动除湿。 这种吹扫将环境湿度快速地降低到所需的相对湿度（RH），例如小于约15％RH，实际上消除了霜冻的积聚。 例如，使用条形码技术系统地识别微孔板。 一旦通过气候控制室，容器（即样品）被机械地转移到旋转机构。 这种机构将容器运送到存储装置（例如转盘或固定地址中的一个）上的衍生嵌套位置。
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公开(公告)号：US09074016B2
公开(公告)日：2015-07-07
申请号：US12315338
申请日：2008-12-01
申请人： Robin A. Felder , Pedro Jose
发明人： Robin A. Felder , Pedro Jose
IPC分类号： C07K14/72
CPC分类号： C07K14/723 , A01K2217/05 , A01K2217/056
摘要： Disclosed are methods for identifying individuals predisposed to essential hypertension and related conditions such as salt sensitivity by detecting the presence of polymorphic or mutant forms of the GRK4 gene, or its expression product. Also disclosed are methods for identifying polymorphic or mutant GRK4s in individuals known to be suffering from such conditions, as well as methods and compositions for conducting drug discovery and therapeutic intervention.
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公开(公告)号：US08090426B2
公开(公告)日：2012-01-03
申请号：US11588974
申请日：2006-10-27
申请人： Robin A. Felder
发明人： Robin A. Felder
IPC分类号： A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/14546 , A61B5/6821 , A61F9/00772
摘要： A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctual plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.
摘要翻译： 公开了一种能够提供与体液的物理或化学性质相关的信息的插头，或其中存在或数量的活体中的分子成分。 具体地，一个实施例的插头能够插入到人眼的一部分中以便提供与泪液相关的信息。 该实施例的塞子包括具有允许泪液自然流过其中的通道的主体。 此外，提供了一种感测机构，其能够通过分析泪液测量例如患者体内的葡萄糖水平。 这种塞子可进一步被设计成可以用作防止干眼症的准时塞子的两倍。 还公开了利用和植入这种插头的方法。
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