公开(公告)号：US09005547B2

公开(公告)日：2015-04-14

申请号：US13428683

申请日：2012-03-23

申请人： Keiji Iwamoto ,  Kazuhiro Oguchi ,  Kenji Hamachi

发明人： Keiji Iwamoto ,  Kazuhiro Oguchi ,  Kenji Hamachi

IPC分类号： B01L3/00 ,  G01N21/07 ,  G01N35/00 ,  G01N21/64

CPC分类号： G01N33/5302 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/5085 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N21/07 ,  G01N21/6428 ,  G01N35/00069

摘要： The present invention provides a disc-like assay chip, and more specifically, the present invention provides an assay chip which can effectively clean a cleaned object existing in a fluid loop, and can be appropriately applied to a detection method of a reaction system using a step of necessarily cleaning the cleaned object, such as an immunofluorescent antibody method, and applied to a detection method using an enzymatic reaction (especially, an ELISA method). The present invention further provides a disc-like assay chip which is mounted on a centrifugal device such as a rotational disc and can perform detection or quantitation on a target substance through optical measurement after a specimen and a reagent react by use of a centrifugal force generated by rotation of the centrifugal device.

摘要翻译： 本发明提供一种盘状测定芯片，更具体地说，本发明提供一种能够有效地清洁存在于流体回路中的被清洁物体的测定芯片，并且可以适当地应用于使用 必须清洁被清洁物体的步骤，例如免疫荧光抗体法，并应用于使用酶反应的检测方法（特别是ELISA法）。 本发明还提供了一种盘状测定芯片，其安装在诸如旋转盘的离心装置上，并且可以通过使用产生的离心力在样品和试剂反应之后通过光学测量对目标物质进行检测或定量 通过离心装置的旋转。

公开(公告)号：US08900528B2

公开(公告)日：2014-12-02

申请号：US13560524

申请日：2012-07-27

申请人： Kenji Hamachi ,  Keiji Iwamoto ,  Kazuhiro Oguchi

发明人： Kenji Hamachi ,  Keiji Iwamoto ,  Kazuhiro Oguchi

IPC分类号： B01L3/00

CPC分类号： B01L3/50273 ,  B01L2200/027 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0409

摘要： A disc-shaped analysis chip has an internal space. The internal space includes: a first reservoir for accommodating a first liquid; a second reservoir and a third reservoir arranged nearer to an outer peripheral portion of the analysis chip than the first reservoir; a fourth reservoir, a fifth reservoir and a sixth reservoir for accommodating a second liquid, a third liquid and a fourth liquid, respectively, and being arranged nearer to the outer peripheral portion of the analysis chip than the second and the third reservoir; a seventh reservoir arranged nearer to the outer peripheral portion of the analysis chip than the fourth to the sixth reservoir; an eighth reservoir arranged nearer to the outer peripheral portion of the analysis chip than the seventh reservoir; and a first to an eighth flow path for appropriately interconnecting the first to the eighth reservoir.

摘要翻译： 盘形分析芯片具有内部空间。 内部空间包括：用于容纳第一液体的第一储存器; 第二储存器和第三储存器，布置成比所述第一储存器更靠近所述分析芯片的外周部分; 分别容纳第二液体，第三液体和第四液体的第四储存器，第五储存器和第六储存器，并且布置成比第二和第三储存器更靠近分析芯片的外周部分; 第七容器，布置成比第四至第六储存器更靠近分析芯片的外周部分; 第八储存器，其布置成比所述第七储存器更靠近所述分析芯片的外周部分; 以及用于适当地互连第一至第八贮存器的第一至第八流路。

公开(公告)号：US20120244607A1

公开(公告)日：2012-09-27

申请号：US13428683

申请日：2012-03-23

申请人： Keiji Iwamoto ,  Kazuhiro Oguchi ,  Kenji Hamachi

发明人： Keiji Iwamoto ,  Kazuhiro Oguchi ,  Kenji Hamachi

IPC分类号： C12M1/40 ,  G01N21/64

CPC分类号： G01N33/5302 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/5085 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N21/07 ,  G01N21/6428 ,  G01N35/00069

摘要： The present invention provides a disc-like assay chip, and more specifically, the present invention provides an assay chip which can effectively clean a cleaned object existing in a fluid loop, and can be appropriately applied to a detection method of a reaction system using a step of necessarily cleaning the cleaned object, such as an immunofluorescent antibody method, and applied to a detection method using an enzymatic reaction (especially, an ELISA method). The present invention further provides a disc-like assay chip which is mounted on a centrifugal device such as a rotational disc and can perform detection or quantitation on a target substance through optical measurement after a specimen and a reagent react by use of a centrifugal force generated by rotation of the centrifugal device.

摘要翻译： 本发明提供一种盘状测定芯片，更具体地说，本发明提供一种能够有效地清洁存在于流体回路中的被清洁物体的测定芯片，并且可以适当地应用于使用 必须清洁被清洁物体的步骤，例如免疫荧光抗体法，并应用于使用酶反应的检测方法（特别是ELISA法）。 本发明还提供了一种盘状测定芯片，其安装在诸如旋转盘的离心装置上，并且可以通过使用产生的离心力在样品和试剂反应之后通过光学测量对目标物质进行检测或定量 通过离心装置的旋转。

公开(公告)号：US20080306287A1

公开(公告)日：2008-12-11

申请号：US11668000

申请日：2005-11-18

申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada ,  Taku Nakamura ,  Keiji Iwamoto

发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada ,  Taku Nakamura ,  Keiji Iwamoto

IPC分类号： C07D309/08

CPC分类号： C07D309/08

摘要： The present invention is to provide a process for preparing tetrahydropyran-4-carboxylic acid represented by the formula (1): which comprises hydrolyzing a 4-cyanotetrahydropyran-4-carboxylic acid compound represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, in the presence of an acid; a process for preparing a tetrahydropyran-4-carboxylic acid ester which comprises reacting the tetrahydropyran-4-carboxylic acid represented by the above-mentioned formula (1) with an alcohol in the presence of an acid; and a process for preparing tetrahydropyran-4-carboxylic acid amide which comprises reacting the tetrahydropyran-4-carboxylic acid represented by the above-mentioned formula (1) with a halogenating agent to prepare tetrahydropyran-4-carboxylic acid halide, and then, reacting an amine compound to the resulting compound.

摘要翻译： 本发明提供一种制备由式（1）表示的四氢吡喃-4-羧酸的方法：其包括水解由式（2）表示的4-氰基四氢吡喃-4-羧酸化合物：其中R表示氢 原子或烃基，在酸的存在下; 制备四氢吡喃-4-羧酸酯的方法，其包括在酸存在下使由上述式（1）表示的四氢吡喃-4-羧酸与醇反应; 以及制备四氢吡喃-4-羧酸酰胺的方法，其包括使由上述式（1）表示的四氢吡喃-4-羧酸与卤化剂反应以制备四氢吡喃-4-羧酸卤化物，然后使 向所得化合物中加入胺化合物。

公开(公告)号：US07365215B2

公开(公告)日：2008-04-29

申请号：US10564709

申请日：2004-07-14

申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada ,  Shinobu Suzuki

发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada ,  Shinobu Suzuki

IPC分类号： C07D315/00

CPC分类号： C07D309/10 ,  C07D309/14

摘要： The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (1): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (2): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, a noble metal catalyst and a metal oxide, and a synthetic intermediate thereof and a process for preparing the same.

摘要翻译： 本发明涉及一种由式（1）表示的4-氨基四氢吡喃化合物及其酸式盐的制备方法：其中R表示氢原子或烃基，其包括使4-肼基四氢吡喃化合物或其酸式盐 由式（2）表示：其中R具有与上述相同的含义，在至少一种选自阮内镍，贵金属催化剂和金属氧化物的化合物及其合成中间体存在下进行分解反应，和 制备方法

公开(公告)号：US07300953B2

公开(公告)日：2007-11-27

申请号：US10572373

申请日：2004-09-17

申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

IPC分类号： A61K31/075 ,  C07D309/08

CPC分类号： C07C253/30 ,  C07C51/00

摘要： The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R represents a cyano group, a carboxyl group or an ester group, R1 and R2 each represent a group which does not participate in the reaction, which may have a substituent, and R1 and R2 may be combined to each other to form a ring, which comprises subjecting an acetic acid compound represented by the formula (1): wherein R, R1 and R2 have the same meanings as defined above, to decarboxylation in the presence of a metal catalyst.

摘要翻译： 本发明公开了一种制备由式（2）表示的腈化合物，羧酸化合物或羧酸酯化合物的方法：其中R表示氰基，羧基或酯基，R 1 R 2和R 2各自表示不参与反应的基团，其可以具有取代基，R 1和R 2， SUP>可以彼此组合以形成环，其包括使由式（1）表示的乙酸化合物：其中R，R 1和R 2， 具有与上述相同的含义，在金属催化剂的存在下脱羧。

公开(公告)号：US20060063711A1

公开(公告)日：2006-03-23

申请号：US10533066

申请日：2003-10-28

申请人： Keiji Iwamoto ,  Nozomi Katayama ,  Mihoko Kawamura

发明人： Keiji Iwamoto ,  Nozomi Katayama ,  Mihoko Kawamura

IPC分类号： A61K38/17

CPC分类号： G01N33/6872 ,  A61K31/7088 ,  G01N33/5044 ,  G01N33/66 ,  G01N2800/042 ,  G01N2800/044

摘要： The present invention provides an agent that inhibits or promotes glucose uptake in the small intestine, etc., comprising a compound that inhibits or promotes the activity of Na+/glucose transporter (SGLT) homologs.

摘要翻译： 本发明提供抑制或促进小肠中葡萄糖摄取的药物等，其包含抑制或促进Na + /葡萄糖转运蛋白（SGLT）同源物的活性的化合物。

公开(公告)号：US20140066571A1

公开(公告)日：2014-03-06

申请号：US14004362

申请日：2012-03-12

申请人： Ryoichi Takasawa ,  Takuya Oka ,  Yukinori Kohama ,  Miharu Nakagawa ,  Keiji Iwamoto ,  Kenji Hirotsu ,  Yoshiyuki Watanabe

发明人： Ryoichi Takasawa ,  Takuya Oka ,  Yukinori Kohama ,  Miharu Nakagawa ,  Keiji Iwamoto ,  Kenji Hirotsu ,  Yoshiyuki Watanabe

IPC分类号： C08G73/14 ,  C08G69/00

CPC分类号： C08G73/1085 ,  B05D1/30 ,  B05D3/0254 ,  B05D3/0413 ,  B29C39/02 ,  B29C39/22 ,  B29K2079/08 ,  B29K2995/0012 ,  B29K2995/0016 ,  B29K2995/0026 ,  B29K2995/0037 ,  B29K2995/0082 ,  B29L2031/34 ,  C08G69/00 ,  C08G73/0644 ,  C08G73/1078 ,  C08G73/14 ,  C08J5/18 ,  C08J2379/08 ,  C09D179/08 ,  H01L31/03926 ,  H01M14/005 ,  Y02E10/50

摘要： A polyimide precursor comprising a repeating unit represented by the following chemical formula (1): in which A is a tetravalent group having at least one aliphatic six-membered ring and no aromatic ring in the chemical structure, and B is a divalent group having at least one amide bond and an aromatic ring in the chemical structure; or A is an aliphatic tetravalent group and B is a divalent group having at least one chemical structure represented by the following chemical formula (2) in the chemical structure: and X1 and X2 are each independently hydrogen, a C1-6 alkyl group or a C3-9 alkylsilyl group.

摘要翻译： 包含由以下化学式（1）表示的重复单元的聚酰亚胺前体：其中A是在化学结构中具有至少一个脂族六元环且不具有芳环的四价基团，B是具有 化学结构中最少一个酰胺键和芳环; 或A是脂族四价基团，B是在化学结构中具有由以下化学式（2）表示的至少一种化学结构的二价基团：X 1和X 2各自独立地为氢，C 1-6烷基或 C3-9烷基甲硅烷基。

公开(公告)号：US20070043107A1

公开(公告)日：2007-02-22

申请号：US10583473

申请日：2004-12-17

申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

IPC分类号： A61K31/35 ,  C07D309/06

CPC分类号： C07D309/06

摘要： The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be the same or different from each other, and represent a group which does not participate in the reaction, and R1 and R2 may be bonded to form a ring, and the ring may contain a hetero atom(s), and R3 represents a hydrocarbon group, which comprises reacting 4-acyltetrahydropyran represented by the formula (2): wherein R1 and R2 have the same meanings as defined above, and a carbonic acid diester represented by the formula (3): wherein R3 has the same meanings as defined above, and two R3s may be bonded to each other to form a ring, in the presence of a base, and a process for preparing 4-acyltetrahydropyran.

摘要翻译： 本发明提供一种制备由式（1）表示的3-（4-四氢吡喃基）-3-氧代丙酸烷基酯化合物的方法：其中R 1和R 2， SUP>可以相同也可以不同，表示不参与反应的基团，R 1和R 2可以相互键合形成 环可以含有杂原子，R 3表示烃基，其包括使由式（2）表示的4-酰基四氢吡喃：其中R 1， / O 2和R 2具有与上述相同的含义，和由式（3）表示的碳酸二酯：其中R 3具有与所定义的相同的含义 并且两个R 3可以在碱的存在下彼此键合形成环，以及制备4-酰基四氢吡喃的方法。

公开(公告)号：US07741497B2

公开(公告)日：2010-06-22

申请号：US10583473

申请日：2004-12-17

申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

IPC分类号： C07D309/06

CPC分类号： C07D309/06

摘要： The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be the same or different from each other, and represent a group which does not participate in the reaction, and R1 and R2 may be bonded to form a ring, and the ring may contain a hetero atom(s), and R3 represents a hydrocarbon group, which comprises reacting 4-acyltetrahydropyran represented by the formula (2): wherein R1 and R2 have the same meanings as defined above, and a carbonic acid diester represented by the formula (3): wherein R3 has the same meanings as defined above, and two R3s may be bonded to each other to form a ring, in the presence of a base, and a process for preparing 4-acyltetrahydropyran.

摘要翻译： 本发明提供一种制备式（1）表示的3-（4-四氢吡喃基）-3-氧代丙酸烷基酯化合物的方法：其中R 1和R 2可以相同或不同，并且表示基团 其不参与反应，并且R 1和R 2可以键合形成环，并且该环可以含有杂原子，并且R 3表示烃基，其包括使由式（Ⅳ）表示的4-酰基四氢吡喃与 2）：其中R1和R2具有与上述相同的含义，和由式（3）表示的碳酸二酯：其中R 3具有与上述相同的含义，并且两个R 3可以彼此键合形成 在碱的存在下，以及制备4-酰基四氢吡喃的方法。