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公开(公告)号：US20090149398A1
公开(公告)日：2009-06-11
申请号：US10586415
申请日：2005-01-19
IPC分类号： A61K31/7048 , C07H17/08 , A61P3/04 , C07H17/00
CPC分类号： C07H17/08
摘要： Compounds of Formula (I), and pharmaceutically acceptable salts, esters, and prodrugs thereof: (I) are disclosed, wherein A, B, D, L, X, Y, Z and R2′, are described herein. The compounds exhibit antibacterial properties. The compounds of Formula (I) can be employed to treat or prevent bacterial infections as compounds per se or in the form of pharmaceutically acceptable salts, esters, or prodrugs. The compounds and their salts, esters, and prodrugs can also be employed as ingredients in pharmaceutical compositions, optionally in combination with other antibacterial agents, for the treatment of bacterial infections. Processes for making the compounds are also disclosed.
摘要翻译： 公开了式（I）化合物及其药学上可接受的盐，酯和前体药物：（I），其中A，B，D，L，X，Y，Z和R2'在本文中描述。 该化合物表现出抗菌性能。 式（I）的化合物可用于治疗或预防细菌感染作为化合物本身或以药学上可接受的盐，酯或前药的形式。 化合物及其盐，酯和前药也可以用作药物组合物中的成分，任选地与其它抗菌剂组合用于治疗细菌感染。 还公开了制备化合物的方法。
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公开(公告)号：US6110697A
公开(公告)日：2000-08-29
申请号：US716978
申请日：1996-09-20
CPC分类号： G01N33/6875 , A61K38/005 , A61K38/12 , C07K5/126 , C12Q1/025 , C12Q1/18 , G01N2333/445 , G01N2333/455 , Y10S514/895
摘要： Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.
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公开(公告)号：US5310873A
公开(公告)日：1994-05-10
申请号：US492001
申请日：1990-03-12
IPC分类号： A61K38/00 , A61P31/10 , A61P35/00 , C07K1/113 , C07K7/56 , C07K14/195 , C07K14/41 , C12N9/80 , C12P21/02 , C12P21/04 , C12R1/01 , C12R1/38 , A61K37/02 , C07K5/12 , C07K7/06
CPC分类号： C07K7/56
摘要： A cyclohexapeptide base which is the nucleus of closely related antibiotics obtained by culturing Zalerion arboricola and its salts are described. They are useful intermediates for the preparation of new semisynthetic compounds having antimicrobial activity.
摘要翻译： 描述了通过培养Zalerion arboricola及其盐获得的紧密相关抗生素核的环己肽基。 它们是制备具有抗微生物活性的新的半合成化合物的有用中间体。
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公开(公告)号：US06428983B1
公开(公告)日：2002-08-06
申请号：US09296834
申请日：1999-04-22
IPC分类号： C12N2106
CPC分类号： G01N33/6875 , A61K38/005 , A61K38/12 , C07K5/126 , C12Q1/025 , C12Q1/18 , G01N2333/445 , G01N2333/455 , Y02A50/411 , Y10S514/895
摘要： Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.
摘要翻译： 组蛋白脱乙酰酶抑制提供了鉴定潜在的抗原生动物化合物的靶标。 组蛋白脱乙酰酶抑制剂可用作抗原生动物感染的治疗剂。
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公开(公告)号：US5202309A
公开(公告)日：1993-04-13
申请号：US749633
申请日：1991-08-19
申请人： Robert E. Schwartz , Jerrold M. Liesch , Raymond F. White , Otto D. Hensens , Henry Joshua , Dennis M. Schmatz
发明人： Robert E. Schwartz , Jerrold M. Liesch , Raymond F. White , Otto D. Hensens , Henry Joshua , Dennis M. Schmatz
摘要： An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity is described. Its production and isolation are also described.
摘要翻译： 描述了通过培养作为对人类病原体具有非常高的活性且具有非常低的哺乳动物毒性的环状脂肽的Zalerion arboricola产生的抗生素。 还描述了其生产和分离。
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公开(公告)号：US4724145A
公开(公告)日：1988-02-09
申请号：US798775
申请日：1985-11-18
申请人： Peter K. Murray , Balbir S. Bhogal , Ethel B. Jacobson , Mark S. Crane , Dennis M. Schmatz , Stefan Galuska
发明人： Peter K. Murray , Balbir S. Bhogal , Ethel B. Jacobson , Mark S. Crane , Dennis M. Schmatz , Stefan Galuska
IPC分类号： A61K39/00 , A61K39/012 , C07K14/455 , A61K39/002
CPC分类号： C07K14/455 , A61K39/012 , A61K39/00 , Y10S435/803 , Y10S435/947 , Y10S530/822
摘要： High levels of immunity are achieved in chickens inoculated intramuscularly or orally with E. acervulina extract immunogens. These extracts contain at least 20 polypeptides which induce a protective immune response not only against E. acervulina but also against E. tenella and E. maxima. The resulting immunity prevents intestinal lesions and reduces the number of viable oocysts in vaccinated and challenged birds. One or more of these polypeptides can be used as an immunogen to protect against coccidiosis.
摘要翻译： 通过肌内或口服E.acervulina提取物免疫原接种的鸡获得高水平的免疫。 这些提取物含有至少20种多肽，它们不仅能针对艾美菌（E.acervulina）而且还能针对E. tenella和E.gala 所产生的免疫力可防止肠道病变，并减少接种疫苗和攻击型鸟类的活卵囊数。 这些多肽中的一种或多种可以用作免疫原以防止球虫病。
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公开(公告)号：US07504501B2
公开(公告)日：2009-03-17
申请号：US10548154
申请日：2004-03-02
IPC分类号： C07D403/04 , A61K31/429
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidial agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).
摘要翻译： 由式（I）表示的化合物：（I）或其药学上可接受的盐或N-氧化物。 该化合物可用于治疗和预防哺乳动物和鸟类中的原生动物疾病。 控制家禽中球虫病的方法包括单独施用有效量的化合物，或与一种或多种抗球虫剂组合施用。 用于控制家禽中球虫病的组合物包含单独的化合物，或与一种或多种抗球虫剂组合。 用于治疗和预防哺乳动物原生动物疾病的方法，例如弓形虫病，疟疾，非洲锥虫病，恰加斯病和机会性感染包括单独施用化合物，或与一种或多种抗原虫剂组合施用。
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公开(公告)号：US5922837A
公开(公告)日：1999-07-13
申请号：US789347
申请日：1997-01-27
摘要： The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis. The invention also relates to the use of known compounds which are histone deacetylase inhibitors as antiprotozoal agents.
摘要翻译： 本发明提供了可用于治疗或预防原生动物疾病的新型环状四肽; 特别是新型化合物对疟疾，弓形虫病和球虫病引起的病原体具有抗性。 本发明还涉及作为组蛋白脱乙酰酶抑制剂的已知化合物作为抗原虫剂的用途。
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公开(公告)号：US5166135A
公开(公告)日：1992-11-24
申请号：US743473
申请日：1991-08-09
申请人： Dennis M. Schmatz
发明人： Dennis M. Schmatz
摘要： A method for the treatment of Pneumocystis carinii, the causative agent of pneumonia of particular severity to immune compromised patients such as those with acquired immune deficiency syndrome (AIDS), by administering a lipophilic cyclohexapeptide compound of the general formula ##STR1## wherein the R groups are fully defined in the text, is described. Compositions suitable for the treatment of P. carinii are also disclosed.
摘要翻译： 一种通过给予通式（I）的亲脂性环己肽化合物来治疗卡氏肺囊虫的方法，所述肺炎球菌是免疫受损的患者（例如具有获得性免疫缺陷综合征（AIDS）的患者）特别严重的致病因子，其中 描述了R组在文本中的完全定义。 还公开了适合于处理卡氏梭菌的组合物。
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10.发明授权(Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds 失效（嘧啶基）（苯基）取代的稠合杂芳基p38抑制和PKG激酶抑制化合物公开(公告)号：US07196095B2
公开(公告)日：2007-03-27
申请号：US10477367
申请日：2002-06-21
申请人： Tesfaye Biftu , Richard Beresis , Richard Berger , Steven L. Colletti , James B. Doherty , Dennis D. Feng , Gui-Bai Liang , Dennis M. Schmatz , Xiaoxia Qian , David A. Claremon , Nigel J. Liverton , Charles J. McIntyre , Ernest W. Kovacs
发明人： Tesfaye Biftu , Richard Beresis , Richard Berger , Steven L. Colletti , James B. Doherty , Dennis D. Feng , Gui-Bai Liang , Dennis M. Schmatz , Xiaoxia Qian , David A. Claremon , Nigel J. Liverton , Charles J. McIntyre , Ernest W. Kovacs
IPC分类号： C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , A61K31/506 , A61P19/02
CPC分类号： C07D403/04 , A23K20/10 , A23K20/111 , A61K31/429 , A61K31/4355 , A61K31/506 , A61K31/519 , A61K31/53 , A61K45/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/14 , C07D513/04 , A61K2300/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are useful in the treatment of cytokine mediated diseases such as arthritis and in the treatment and/or prevention of protozoal diseases such as coccidiosis
摘要翻译： 式（I）化合物及其药学上可接受的盐可用于治疗细胞因子介导的疾病如关节炎和治疗和/或预防原虫感染疾病如球虫病
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