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    METHOD FOR IN-SITU RADIATION-PRIMED T-CELL THERAPY
    4.
    发明申请
    METHOD FOR IN-SITU RADIATION-PRIMED T-CELL THERAPY 审中-公开

    公开(公告)号：US20190275086A1

    公开(公告)日：2019-09-12

    申请号：US16163542

    申请日：2018-10-17

    申请人： Xiaodong Wu ,  Sunil Krishnan

    发明人： Xiaodong Wu ,  Sunil Krishnan

    IPC分类号： A61K35/26 ,  A61N5/10 ,  C12N5/0783

    摘要： The present invention as described herein is aimed at combining a radiation-induced immunogenic effect with a T-cell therapy technique to markedly improve the therapeutic effectiveness of adoptive T-cell therapy with minimized toxicity. The method of this invention comprises, identifying a target tumor, applying ablative radiation treatment to the tumor in-situ, waiting for the production of CTLs primed by antigen presenting cells (APC), then resecting the target tumor from the patient. The CTLs are harvested and isolated from the tumor and undergo ex-vivo expansion and subsequent treatment of immune checkpoint blockades. The expanded CTLs are then infused back into the patient for systemic treatment of microscopic disease. The primed CTLs that are induced by radiation in-situ, are used as the source of T-cell therapy or other types of cell therapy. The harvested CTLs will have high tumor specificity with a wide range of heterogeneous tumor associated antigens (TAA) presentation.

    Self-Contained Device and System to Produce Ex-Vivo Autologous Whole Cell Tumor Vaccines
    5.
    发明申请
    Self-Contained Device and System to Produce Ex-Vivo Autologous Whole Cell Tumor Vaccines 审中-公开
    自体装置和系统产生体外自体全细胞肿瘤疫苗

    公开(公告)号：US20160230139A1

    公开(公告)日：2016-08-11

    申请号：US14948377

    申请日：2015-11-22

    申请人： Xiaodong Wu ,  Chandan Guha

    发明人： Xiaodong Wu ,  Chandan Guha

    IPC分类号： C12M1/00 ,  C12M1/12 ,  A61K39/00

    CPC分类号： C12M47/06 ,  A61K39/0011 ,  A61K2039/5152 ,  C12M23/34 ,  C12M35/04 ,  C12M45/06 ,  C12M45/07 ,  C12M45/20 ,  C12M47/10 ,  C12M47/12

    摘要： The invention disclosed herein aims to standardize and simplify the process of preparing Ex-Vivo autologous whole tumor cell vaccines. The present invention is a robust, stand-alone device and system for preparing autologous tumor cell vaccines in a completely self-contained sterile environment, and in a shortened time. This new device and system will process the extracted tumor with its associated stromal and endothelial cells into injectable tumor cell vaccines, administered automatically or semi-automatically. This invention incorporates a number of new biotechnologies to enhance therapeutic effects over other existing methods. This invention will allow a medical facility to prepare and administer autologous cancer cell vaccine therapy independently without having, or using, a GMP facility, while adhering to and maintaining GMP guidelines.

    摘要翻译： 本文公开的发明旨在标准化和简化制备体外自体全肿瘤细胞疫苗的方法。 本发明是一种用于在完全独立的无菌环境中并在缩短的时间内制备自体肿瘤细胞疫苗的稳健的独立装置和系统。 这种新的装置和系统将将提取的肿瘤及其相关的基质和内皮细胞处理成可注射的肿瘤细胞疫苗，自动或半自动进行。 本发明结合了许多新的生物技术来增强对其他现有方法的治疗效果。 本发明将允许医疗机构在不附带或使用GMP设施的情况下独立地制备和施用自体癌细胞疫苗疗法，同时遵守和维护GMP指南。

    Microwave motion sensor with a reflector
    6.
    发明授权
    Microwave motion sensor with a reflector 有权
    带反射镜的微波运动传感器

    公开(公告)号：US08618999B2

    公开(公告)日：2013-12-31

    申请号：US11940038

    申请日：2007-11-14

    申请人： Xiaodong Wu ,  James N. Helland ,  Leslie K. Green

    发明人： Xiaodong Wu ,  James N. Helland ,  Leslie K. Green

    IPC分类号： H01Q19/10 ,  H01Q1/38

    CPC分类号： H01Q9/04 ,  H01Q19/10

    摘要： A microwave motion sensor including a patch antenna having a plurality of microwave radiating elements for transmitting and receiving a microwave signal where each microwave radiating element is of the antenna in an array configuration. A reflector is disposed above the antenna for downward shaping the radiating signal, where the microwave radiating elements together with the reflector provide a radiation pattern where a main beam is transmitted in a direction orthogonal to a surface of said antenna and a sided lobe transmitted downward in amplitude below the microwave motion sensor.

    摘要翻译： 一种微波运动传感器，包括具有多个微波辐射元件的贴片天线，用于发送和接收微波信号，其中每个微波辐射元件是阵列配置的天线。 反射器设置在天线上方，用于向下成形辐射信号，其中微波辐射元件与反射器一起提供辐射图，其中主光束在与所述天线的表面正交的方向上传输， 幅度低于微波运动传感器。

    SYSTEM FOR SORTING AND CLASSIFYING USERS OF AN IMAGE INFORMATION MANAGEMENT SYSTEM
    7.
    发明申请
    SYSTEM FOR SORTING AND CLASSIFYING USERS OF AN IMAGE INFORMATION MANAGEMENT SYSTEM 有权
    用于分类和分类图像信息管理系统的用户的系统

    公开(公告)号：US20110055211A1

    公开(公告)日：2011-03-03

    申请号：US12674883

    申请日：2008-08-22

    申请人： Shishu Mei ,  Zhen Wang ,  Xiaodong Wu

    发明人： Shishu Mei ,  Zhen Wang ,  Xiaodong Wu

    IPC分类号： G06F17/30

    CPC分类号： G06F21/6218 ,  H04N21/2541 ,  H04N21/25875 ,  H04N21/26613 ,  H04N21/6334

    摘要： A system for sorting and classifying users of an image information management system is disclosed. The system for sorting and classifying users of an image information management system according to the present invention comprises some identical sub-systems, and every two sub-systems are interconnected. The sub-system comprises a user information encoding module, a user information decoding and authority identifying module, a user sorting module, a user classifying module, a command performing module, an authorized user collection database and a resource information database. The resource information database comprises real-time images, history images and control right commands of cradle heads and lens of cameras. The present invention resolves the problem of ordered accessing and utilizing of image information in a super-large-scale advanced real-time monitoring information management system, and realizes the object that local failures do not affect the normal work of the other parts by connecting every two sub-systems to each other and arranging the user identification entrance in each one of sub-systems.

    摘要翻译： 公开了一种用于对图像信息管理系统的用户进行分类和分类的系统。 根据本发明的用于对图像信息管理系统的用户进行分类和分类的系统包括一些相同的子系统，并且每两个子系统互连。 子系统包括用户信息编码模块，用户信息解码和权限识别模块，用户分类模块，用户分类模块，命令执行模块，授权用户收集数据库和资源信息数据库。 资源信息数据库包括摇摄头和相机镜头的实时图像，历史图像和控制权命令。 本发明解决了超大规模高级实时监控信息管理系统中图像信息有序访问和利用的问题，实现了本地故障不影响其他部分的正常工作的对象，方法是连接每个 两个子系统彼此并且在每个子系统中布置用户识别入口。

    Method for Three Dimensional (3D) Lattice Radiotherapy
    8.
    发明申请
    Method for Three Dimensional (3D) Lattice Radiotherapy 有权
    三维（3D）晶格放射治疗方法

    公开(公告)号：US20100320402A1

    公开(公告)日：2010-12-23

    申请号：US12819212

    申请日：2010-06-20

    申请人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

    发明人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

    IPC分类号： A61N5/10

    CPC分类号： A61N5/1031

    摘要： A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

    摘要翻译： 本文描述了利用三维（3D）剂量格子形成的大剂量网格放射治疗方法。 3D剂量网格可以通过但不限于三种技术方法来实现：1）非共面聚焦束; 2）基于多叶准直器（MLC）的强度调制放射治疗（IMRT）或孔径调制电弧; 和3）重带电粒子束。 3D剂量网格的配置由剂量顶点的数量，位置和剂量组成。 3D剂量网格的最佳配置可以通过手动计算或通过自动化一般算法的计算来实现。 优化算法的目的是通过迭代满足三个条件，直到达到其全局最小值。 使用3D剂量网格，高剂量的辐射集中在肿瘤内的每个晶格顶点，顶点之间具有非常低的剂量（峰 - 谷效应），使组织在肿瘤体外的最低限度暴露。

    Microwave smart motion sensor for security applications
    9.
    发明授权
    Microwave smart motion sensor for security applications 失效
    微波智能运动传感器，用于安全应用

    公开(公告)号：US07616148B2

    公开(公告)日：2009-11-10

    申请号：US11286206

    申请日：2005-11-23

    申请人： Xiaodong Wu ,  Harold L. Holvick ,  Leslie K. Green ,  James N. Helland

    发明人： Xiaodong Wu ,  Harold L. Holvick ,  Leslie K. Green ,  James N. Helland

    IPC分类号： G01S13/62

    CPC分类号： G08B13/2494 ,  G08B29/183

    摘要： A dual mode motion sensor for detecting both motion of a moving target and a range of the moving target. The dual mode motion sensor normally operates in a pulse transmission mode. If motion is detected, the sensor automatically switches to a frequency modulated continuous wave transmission mode. This will allow the sensor to determine the range of the moving target. The sensor includes a microcontroller that compares the determined range of the moving target with a predetermined maximum detection range. If the determined range is outside or exceeds the predetermined maximum detection range the sensor will ignore the motion. If the determined range is within the predetermined maximum detection range, an alarm will be generated.

    摘要翻译： 一种用于检测移动目标的运动和移动目标的范围的双模运动传感器。 双模运动传感器通常在脉冲传输模式下工作。 如果检测到运动，则传感器自动切换到调频连续波传输模式。 这将允许传感器确定移动目标的范围。 该传感器包括将所确定的移动目标的范围与预定的最大检测范围进行比较的微控制器。 如果确定的范围超出或超过预定的最大检测范围，传感器将忽略该运动。 如果所确定的范围在预定的最大检测范围内，则将产生报警。

    MICROWAVE MOTION SENSOR WITH A REFLECTOR
    10.
    发明申请
    MICROWAVE MOTION SENSOR WITH A REFLECTOR 有权
    具有反射器的微波运动传感器

    公开(公告)号：US20090121958A1

    公开(公告)日：2009-05-14

    申请号：US11940038

    申请日：2007-11-14

    申请人： Xiaodong Wu ,  James N. Helland ,  Leslie K. Green

    发明人： Xiaodong Wu ,  James N. Helland ,  Leslie K. Green

    IPC分类号： H01Q19/10 ,  H01Q9/04

    CPC分类号： H01Q9/04 ,  H01Q19/10

    摘要： A microwave motion sensor including a patch antenna having a plurality of microwave radiating elements for transmitting and receiving a microwave signal where each microwave radiating element is of the antenna in an array configuration. A reflector is disposed above the antenna for downward shaping the radiating signal, where the microwave radiating elements together with the reflector provide a radiation pattern where a main beam is transmitted in a direction orthogonal to a surface of said antenna and a sided lobe transmitted downward in amplitude below the microwave motion sensor.

    摘要翻译： 一种微波运动传感器，包括具有多个微波辐射元件的贴片天线，用于发送和接收微波信号，其中每个微波辐射元件是阵列配置的天线。 反射器设置在天线上方，用于向下成形辐射信号，其中微波辐射元件与反射器一起提供辐射图，其中主光束在与所述天线的表面正交的方向上传输， 幅度低于微波运动传感器。