公开(公告)号：US20190083482A1

公开(公告)日：2019-03-21

申请号：US15707678

申请日：2017-09-18

申请人： Kenneth W. Duncan ,  Richard Chesworth ,  Paula Ann Boriack-Sjodin ,  Michael John Munchhof ,  Lei Jin

发明人： Kenneth W. Duncan ,  Richard Chesworth ,  Paula Ann Boriack-Sjodin ,  Michael John Munchhof ,  Lei Jin

IPC分类号： A61K31/472 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/538

摘要： Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

公开(公告)号：US08410088B2

公开(公告)日：2013-04-02

申请号：US13447007

申请日：2012-04-13

申请人： Kevin W. Kuntz ,  Richard Chesworth ,  Kenneth W. Duncan ,  Masashi Seki ,  Syuji Shirotori

发明人： Kevin W. Kuntz ,  Richard Chesworth ,  Kenneth W. Duncan ,  Masashi Seki ,  Syuji Shirotori

IPC分类号： C07D211/76 ,  C07D413/10 ,  C07D413/12 ,  A61K31/4412

CPC分类号： A61K31/5377 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/551 ,  A61K31/553 ,  C07D213/64 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

摘要： The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US4947181A

公开(公告)日：1990-08-07

申请号：US285919

申请日：1988-12-19

申请人： Kenneth W. Duncan ,  George S. Hardie ,  Robert Jobsky ,  Michael J. Maybell ,  Steven T. Wada

发明人： Kenneth W. Duncan ,  George S. Hardie ,  Robert Jobsky ,  Michael J. Maybell ,  Steven T. Wada

IPC分类号： H01Q13/04

CPC分类号： H01Q13/04

摘要： An improved biconical horn antenna having a broad azimuthal beamwidth and an asymmetrical elevation beam pattern. The antenna comprises two conical sections mounted against a grounded backplane with the tapered ends of the sections facing each other. The sections are of unequal size and have curved edges. The antenna is fed by a rectangular waveguide passing through the backplane between the tapered ends of the sections.

摘要翻译： 一种改进的双锥形喇叭天线，具有宽的方位波束宽度和不对称的仰角波束图案。 该天线包括两个圆锥形部分，这些部分安装在接地背板上，并且该部分的锥形端部彼此面对。 这些部分的尺寸不等，具有弯曲的边缘。 天线由穿过背板之间的矩形波导馈送，在此部分的锥形末端之间。