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8 条记录 (耗时 0.022 秒)

    Variable output vane pump
    5.
    发明授权
    Variable output vane pump 失效
    可变输出叶片泵

    公开(公告)号：US4531893A

    公开(公告)日：1985-07-30

    申请号：US532834

    申请日：1983-09-16

    申请人： Tomio Okoh ,  Tomoaki Matsumoto ,  Noboru Hirokawa

    发明人： Tomio Okoh ,  Tomoaki Matsumoto ,  Noboru Hirokawa

    IPC分类号： F04C14/22 ,  F04C2/344 ,  F04C15/00 ,  F04B49/00

    CPC分类号： F04C14/226 ,  F04C15/0034 ,  F04C2/3442

    摘要： A variable output vane pump for use with an automotive automatic transmission. At least one pressure chamber is formed between the circular bore of a housing and the outer circumference of a ring by means of at least one seal pin which is fitted in the axial groove formed in the ring circumference and which is opened in the housing bore. The ring is urged by the action of a spring, which is fitted in the housing, in a direction opposite to the pressure to be built up by the pressure chamber. An elastic member is fitted in the bottom of the axial groove to urge the seal pin both toward the housing bore and at the same time toward one of the side walls of the axial groove. The urging direction of the elastic member and a tangential line, on which the seal pin is tangential to the housing bore, are angularly positioned at an acute angle with respect to each other.

    摘要翻译： 一种用于汽车自动变速器的可变输出叶片泵。 通过至少一个密封销在壳体的圆形孔和环的外周之间形成至少一个压力室，所述至少一个密封销装配在形成在环形圆周中并在壳体孔中敞开的轴向槽中。 通过弹簧的作用，环被推压，该弹簧以与由压力室构建的压力相反的方向装配在壳体中。 弹性构件装配在轴向凹槽的底部中，以将密封销朝向壳体孔推动，并且同时朝向轴向凹槽的侧壁中的一个侧壁。 弹性构件的推动方向和密封销与壳体孔相切的切线相对于彼此成角度地定位成锐角。

    Synthetic peptide derivatives and the salts thereof
    8.
    发明授权
    Synthetic peptide derivatives and the salts thereof 失效
    合成肽衍生物及其盐

    公开(公告)号：US5908828A

    公开(公告)日：1999-06-01

    申请号：US497599

    申请日：1995-06-30

    申请人： Takashi Kurita ,  Tomoaki Matsumoto ,  Reiko Kikuno ,  Yoko Otawara-Hamamoto ,  Gerhard Breipohl

    发明人： Takashi Kurita ,  Tomoaki Matsumoto ,  Reiko Kikuno ,  Yoko Otawara-Hamamoto ,  Gerhard Breipohl

    IPC分类号： A61K38/00 ,  C07K14/51 ,  A61K38/16 ,  C07K14/00

    CPC分类号： C07K14/51 ,  A61K38/00

    摘要： The present invention provides synthetic peptide derivatives represented by the formulaP.sup.1 -R.sup.1 -P.sup.2wherein P.sup.1 is a peptide having an amino acid sequence in the SEQ ID NO.:1 of the Sequence Listing, or analogues thereof; P.sup.2 is a peptide having an amino acid sequence in the SEQ ID NO.:2 of the Sequence Listing, or analogues thereof; R.sup.1 denotes a linker with a property that does not interfere with the activity of the each peptide P.sup.1 and P.sup.2 to bind N-terminal end of the peptides P.sup.1 and P.sup.2.The present invention also provides a pharmaceutical composition for the treatment of bone related diseases comprising said peptide derivatives, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier.The present invention also provides a method of treating bone related diseases in a mammal comprising administering thereto an effective amount of said peptide derivatives, or therapeutically acceptable salts thereof.

    摘要翻译： 本发明提供由式P1-R1-P2表示的合成肽衍生物，其中P1是具有序列表SEQ ID NO：1中的氨基酸序列的肽或其类似物; P2是具有序列表的SEQ ID NO：2中的氨基酸序列的肽或其类似物; R1表示具有不影响各肽P1和P2与肽P1和P2的N末端结合的活性的性质的连接体。 本发明还提供了用于治疗骨相关疾病的药物组合物，其包含所述肽衍生物或其治疗上可接受的盐和药学上可接受的载体。 本发明还提供了治疗哺乳动物中骨相关疾病的方法，其包括向其施用有效量的所述肽衍生物或其可治疗可接受的盐。