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公开(公告)号:US07659383B2
公开(公告)日:2010-02-09
申请号:US12169222
申请日:2008-07-08
CPC分类号: C07K14/4748 , A61K39/00 , A61K2039/53 , C07K16/30 , C07K2317/23 , C07K2317/34 , C12N2710/24143 , Y10S435/975
摘要: Canine and feline 5T4 polypeptide sequences and nucleotide sequences encoding them are provided. A vector system comprising a nucleic acid encoding 5T4 and a 5T4-specific agent are also provided.
摘要翻译: 提供犬和猫5T4多肽序列和编码它们的核苷酸序列。 还提供了包含编码5T4和5T4特异性试剂的核酸的载体系统。
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公开(公告)号:US06852703B1
公开(公告)日:2005-02-08
申请号:US09445375
申请日:1998-06-04
申请人: Susan Mary Kingsman , Christopher Robert Bebbington , Fiona Margaret Ellard , Miles William Carroll , Kevin Alan Myers
发明人: Susan Mary Kingsman , Christopher Robert Bebbington , Fiona Margaret Ellard , Miles William Carroll , Kevin Alan Myers
IPC分类号: C12N15/09 , A61K35/76 , A61K39/02 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/485 , C07K14/705 , C07K16/30 , C12N15/87 , A61K35/00
CPC分类号: C07K16/40 , C07K14/485 , C07K14/70532 , C07K16/30 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C12N15/87 , C12N2799/027
摘要: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.
摘要翻译: 描述了包含编码感兴趣的产物(“POI”)的感兴趣的核苷酸序列(“NOI”)的载体。 NOI和/或POI能够识别肿瘤,使得在使用中载体能够将NOI和/或POI递送至肿瘤。
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公开(公告)号:US20110065173A1
公开(公告)日:2011-03-17
申请号:US12714264
申请日:2010-02-26
申请人: Susan Mary Kingsman , Christopher Robert Bebbington , Fiona Margaret Ellard , Miles William Carroll , Kevin Alan Myers
发明人: Susan Mary Kingsman , Christopher Robert Bebbington , Fiona Margaret Ellard , Miles William Carroll , Kevin Alan Myers
IPC分类号: C12N15/63
CPC分类号: C07K16/40 , C07K14/485 , C07K14/70532 , C07K16/30 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C12N15/87 , C12N2799/027
摘要: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.
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公开(公告)号:US07531648B2
公开(公告)日:2009-05-12
申请号:US10104522
申请日:2002-03-22
申请人: Susan Mary Kingsman , Christopher Robert Bebbington , Fiona Margaret Ellard , Miles William Carroll , Kevin Alan Myers
发明人: Susan Mary Kingsman , Christopher Robert Bebbington , Fiona Margaret Ellard , Miles William Carroll , Kevin Alan Myers
CPC分类号: C07K16/40 , C07K14/485 , C07K14/70532 , C07K16/30 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C12N15/87 , C12N2799/027
摘要: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.
摘要翻译: 描述了包含编码感兴趣的产物(“POI”)的感兴趣的核苷酸序列(“NOI”)的载体。 NOI和/或POI能够识别肿瘤,使得在使用中载体能够将NOI和/或POI递送至肿瘤。
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公开(公告)号:US20090017532A1
公开(公告)日:2009-01-15
申请号:US12186839
申请日:2008-08-06
申请人: Susan Mary Kingsman , Christopher Robert Bebbington , Fiona Margaret Ellard , Miles William Carroll , Kevin Alan Myers
发明人: Susan Mary Kingsman , Christopher Robert Bebbington , Fiona Margaret Ellard , Miles William Carroll , Kevin Alan Myers
IPC分类号: C12N15/00
CPC分类号: C07K16/40 , C07K14/485 , C07K14/70532 , C07K16/30 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C12N15/87 , C12N2799/027
摘要: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.
摘要翻译: 描述了包含编码感兴趣的产物(“POI”)的感兴趣的核苷酸序列(“NOI”)的载体。 NOI和/或POI能够识别肿瘤,使得在使用中载体能够将NOI和/或POI递送至肿瘤。
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公开(公告)号:US20110052577A1
公开(公告)日:2011-03-03
申请号:US12845380
申请日:2010-07-28
申请人: Alan Kingsman , Susan Mary Kingsman , Christopher Robert Bebbington , Miles William Carroll , Fiona Margaret Ellard , Kevin Alan Myers
发明人: Alan Kingsman , Susan Mary Kingsman , Christopher Robert Bebbington , Miles William Carroll , Fiona Margaret Ellard , Kevin Alan Myers
IPC分类号: A61K39/395 , C07K16/46 , A61P35/00
CPC分类号: C07K16/1063 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/52 , C07K2317/622 , C07K2317/732 , C07K2319/00
摘要: The use of an ScFv Ab (ScFv Ab) capable of recognising a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.
摘要翻译: 描述了能够识别疾病相关分子(DAM)的ScFv Ab(ScFv Ab)在制备用于预防和/或治疗与DAM相关的疾病状况的药物中的用途。 ScFv Ab具有治疗,诊断和预后应用。
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公开(公告)号:US07635687B2
公开(公告)日:2009-12-22
申请号:US10334235
申请日:2002-12-30
申请人: Alan John Kingsman , Christopher Robert Bebbington , Miles William Carroll , Fiona Margaret Ellard , Susan Mary Kingsman , Kevin Alan Myers , Abigail Lamikanra
发明人: Alan John Kingsman , Christopher Robert Bebbington , Miles William Carroll , Fiona Margaret Ellard , Susan Mary Kingsman , Kevin Alan Myers , Abigail Lamikanra
IPC分类号: A61K31/70
CPC分类号: C07K14/485 , A61K2039/505 , C07K14/70532 , C07K16/28 , C07K16/30 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C12N15/87 , C12N2799/027
摘要: The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.
摘要翻译: 本发明提供了包含编码抗体的核苷酸序列的载体系统。 特别地,本发明涉及这样的载体系统在受试者中的用途,其中核苷酸序列在体内表达以产生所述抗体。
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公开(公告)号:US07148035B1
公开(公告)日:2006-12-12
申请号:US09533798
申请日:2000-03-24
IPC分类号: C12P21/06
CPC分类号: C07K14/4748 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C12N2710/24143 , C12N2799/023
摘要: The present invention provides 5T4 tumour-associated antigen (TAA) for use in a method of immunotherapy of tumours. The invention also relates to a recombinant poxvirus vector from which at least one immune evasion gene has been deleted, which comprises a nucleic acid sequence encoding a 5T4 TAA and the use thereof in vaccinating against and in treating tumours.
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公开(公告)号:US08084249B2
公开(公告)日:2011-12-27
申请号:US12714264
申请日:2010-02-26
申请人: Susan Mary Kingsman , Christopher Robert Bebbington , Fiona Margaret Ellard , Miles William Carroll , Kevin Alan Myers
发明人: Susan Mary Kingsman , Christopher Robert Bebbington , Fiona Margaret Ellard , Miles William Carroll , Kevin Alan Myers
IPC分类号: C12N15/00
CPC分类号: C07K16/40 , C07K14/485 , C07K14/70532 , C07K16/30 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C12N15/87 , C12N2799/027
摘要: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.
摘要翻译: 描述了包含编码感兴趣的产物(“POI”)的感兴趣的核苷酸序列(“NOI”)的载体。 NOI和/或POI能够识别肿瘤,使得在使用中载体能够将NOI和/或POI递送至肿瘤。
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公开(公告)号:US20100040539A1
公开(公告)日:2010-02-18
申请号:US12121621
申请日:2008-05-15
申请人: Alan Kingsman , Susan Mary Kingsman , Christopher Robert Bebbington , Miles William Carroll , Fiona Margaret Ellard , Kevin Alan Myers
发明人: Alan Kingsman , Susan Mary Kingsman , Christopher Robert Bebbington , Miles William Carroll , Fiona Margaret Ellard , Kevin Alan Myers
IPC分类号: A61K51/00 , A61K39/395 , C12N9/96 , C12N5/02 , C07K16/00
CPC分类号: C07K16/1063 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/52 , C07K2317/622 , C07K2317/732 , C07K2319/00
摘要: The use of an ScFv Ab (ScFv Ab) capable of recognising a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.
摘要翻译: 描述了能够识别疾病相关分子(DAM)的ScFv Ab(ScFv Ab)在制备用于预防和/或治疗与DAM有关的疾病状况的药物中的用途。 ScFv Ab具有治疗,诊断和预后应用。
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