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公开(公告)号:US08093239B2
公开(公告)日:2012-01-10
申请号:US12128099
申请日:2008-05-28
申请人: Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
发明人: Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
IPC分类号: A61K31/55 , A61K31/505 , A61K31/497 , A61K31/535 , C07D243/08 , C07D413/14 , C07D403/14 , C07D239/02
CPC分类号: C07D471/04
摘要: The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译: 本发明提供咪唑并吡啶化合物,含有它们的组合物,以及其制备方法和用作药剂的方法。
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公开(公告)号:US20080300242A1
公开(公告)日:2008-12-04
申请号:US12128099
申请日:2008-05-28
申请人: Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
发明人: Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
IPC分类号: A61K31/496 , C07D401/04 , C07D279/12 , A61P35/00 , A61K31/541 , A61K31/506
CPC分类号: C07D471/04
摘要: The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译: 本发明提供咪唑并吡啶化合物,含有它们的组合物,以及其制备方法和用作药剂的方法。
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公开(公告)号:US07615643B2
公开(公告)日:2009-11-10
申请号:US11754653
申请日:2007-05-29
申请人: Kevin Kuntz , Kyle Allen Emmitte , Tara Renae Rheault , Stephon Smith , Keith Hornberger , Hamilton Dickson , Mui Cheung
发明人: Kevin Kuntz , Kyle Allen Emmitte , Tara Renae Rheault , Stephon Smith , Keith Hornberger , Hamilton Dickson , Mui Cheung
IPC分类号: A61K31/445 , A61K31/4184 , C07D401/14 , C07D409/04
CPC分类号: C07D409/04 , C07D409/14 , C07D413/14
摘要: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
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公开(公告)号:US20080300247A1
公开(公告)日:2008-12-04
申请号:US11754653
申请日:2007-05-29
申请人: Kevin Kuntz , Kyle Allen Emmitte , Tara Renae Rheault , Stephon Smith , Keith Hornberger , Hamilton Dickson , Mui Cheung
发明人: Kevin Kuntz , Kyle Allen Emmitte , Tara Renae Rheault , Stephon Smith , Keith Hornberger , Hamilton Dickson , Mui Cheung
IPC分类号: A61K31/5377 , A61K31/454 , A61K31/4545 , A61P35/00 , C07D401/14 , C07D409/14 , C07D413/14 , C07D403/14 , A61P7/00 , A61K31/496 , A61K31/513
CPC分类号: C07D409/04 , C07D409/14 , C07D413/14
摘要: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译: 本发明提供了苯并咪唑噻吩化合物含有它们的药物组合物,其制备方法及其作为药剂的用途。
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公开(公告)号:US20100075960A1
公开(公告)日:2010-03-25
申请号:US12303118
申请日:2007-05-29
申请人: Kevin Kuntz , Kyle Allen Emmitte , Tara Renae Rheault , Stephon Smith , Keith Hornberger , Hamilton Dickson , Mui Cheung
发明人: Kevin Kuntz , Kyle Allen Emmitte , Tara Renae Rheault , Stephon Smith , Keith Hornberger , Hamilton Dickson , Mui Cheung
IPC分类号: A61K31/454 , A61K31/5377 , A61K31/496 , A61K31/4545 , C07D413/14 , C07D409/14 , A61P35/00
CPC分类号: C07D409/04 , C07D409/14
摘要: The present invention provides bezimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译: 本发明提供苯扎咪唑噻吩化合物含有其的药物组合物,其制备方法及其作为药剂的用途。
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公开(公告)号:US20090124615A9
公开(公告)日:2009-05-14
申请号:US11754653
申请日:2007-05-29
申请人: Kevin Kuntz , Kyle Allen Emmitte , Tara Renae Rheault , Stephon Smith , Keith Hornberger , Hamilton Dickson , Mui Cheung
发明人: Kevin Kuntz , Kyle Allen Emmitte , Tara Renae Rheault , Stephon Smith , Keith Hornberger , Hamilton Dickson , Mui Cheung
IPC分类号: A61K31/5377 , A61K31/454 , A61K31/4545 , A61P35/00 , C07D401/14 , C07D409/14 , C07D413/14 , C07D403/14 , A61P7/00 , A61K31/496 , A61K31/513
CPC分类号: C07D409/04 , C07D409/14 , C07D413/14
摘要: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译: 本发明提供苯并咪唑噻吩化合物,其含有它们的药物组合物,其制备方法及其作为药剂的用途。
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公开(公告)号:US20090298815A1
公开(公告)日:2009-12-03
申请号:US12434963
申请日:2009-05-04
申请人: Jerry Leroy Adams , Scott Howard Dickerson , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David Edward Uehling , Alex Gregory Waterson , Brian Wilson
发明人: Jerry Leroy Adams , Scott Howard Dickerson , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David Edward Uehling , Alex Gregory Waterson , Brian Wilson
IPC分类号: A61K31/506 , C07D417/04 , C07D417/14 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号: C07D417/14 , A61K31/427 , C07D413/04 , C07D413/14 , C07D417/04
摘要: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译: 本发明提供噻唑磺酰胺和恶唑磺酰胺化合物,含有它们的组合物,以及其制备方法和用作药剂的方法。
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8.2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer 有权
标题翻译: 2- [2- [1H-吡咯并[2,3-D]嘧啶-4-基)氨基]苯甲酰胺衍生物作为IGF-1R抑制剂治疗癌症公开(公告)号:US20100204196A1
公开(公告)日:2010-08-12
申请号:US12671960
申请日:2008-08-06
申请人: Stanley Dawes Chamberlain , Felix Deanda, JR. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
发明人: Stanley Dawes Chamberlain , Felix Deanda, JR. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
IPC分类号: A61K31/397 , C07D487/04 , A61K31/519 , A61K31/496 , A61K31/5377 , A61K31/551 , A61P35/00
CPC分类号: C07D487/04 , C07D487/14
摘要: Novel pyrrolopyrimidines as shown in formula (I): and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.
摘要翻译: 式(I)所示的新型吡咯并嘧啶及其药学上可接受的衍生物。 该化合物可用于抑制IGF-1R。
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9.2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer 有权
标题翻译: 2- [2- {苯基氨基} -1H-吡咯并[2,3-D]嘧啶-4-基)氨基]苯甲酰胺衍生物作为治疗癌症的IGF-1R抑制剂公开(公告)号:US07981903B2
公开(公告)日:2011-07-19
申请号:US12671960
申请日:2008-08-06
申请人: Stanley Dawes Chamberlain , Felix Deanda, Jr. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
发明人: Stanley Dawes Chamberlain , Felix Deanda, Jr. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04 , C07D487/14
摘要: Novel pyrrolopyrimidines as shown in formula (I): and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.
摘要翻译: 式(I)所示的新型吡咯并嘧啶及其药学上可接受的衍生物。 该化合物可用于抑制IGF-1R。
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公开(公告)号:US20060217382A1
公开(公告)日:2006-09-28
申请号:US10550434
申请日:2004-03-29
申请人: Mui Cheung , Nigel King , Kevin Kuntz , Robert Mook , Mark Pobanz , James Salovich , Brian Wilson
发明人: Mui Cheung , Nigel King , Kevin Kuntz , Robert Mook , Mark Pobanz , James Salovich , Brian Wilson
IPC分类号: A61K31/53 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译: 本发明提供式(I)化合物:其中所有变量如本文所定义,含有该化合物的药物组合物,其制备方法及其作为药剂的用途。
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