-
1.Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising N-cyclic P2 moieties 失效
标题翻译: 包含N-环P2部分的丙型肝炎病毒的大环NS3-丝氨酸蛋白酶抑制剂公开(公告)号:US06846802B2
公开(公告)日:2005-01-25
申请号:US09825399
申请日:2001-04-03
申请人: Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Tejal Parekh , Haining Gu , George F. Njoroge , Viyyoor Moopil Girijavallabhan , Ashit Ganguly , Anil Saksena , Edwin Jao , Nanhua Hugh Yao , Andrew Joseph Prongay , Vincent Stewart Madison , Bancha Vibulbhan
发明人: Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Tejal Parekh , Haining Gu , George F. Njoroge , Viyyoor Moopil Girijavallabhan , Ashit Ganguly , Anil Saksena , Edwin Jao , Nanhua Hugh Yao , Andrew Joseph Prongay , Vincent Stewart Madison , Bancha Vibulbhan
IPC分类号: C12N9/99 , A61K31/7052 , A61K38/00 , A61K38/21 , A61K38/55 , A61K45/00 , A61P31/12 , A61P31/14 , A61P43/00 , C07K1/02 , C07K5/023 , C07K5/08 , C07K5/083 , C07K5/12 , C07K7/02 , A16K38/12
CPC分类号: C07K5/12 , A61K38/00 , C07K1/02 , C07K5/08 , C07K5/0802 , C07K5/0806 , C07K7/02
摘要: The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型大环化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这种大环化合物的药物组合物以及使用它们治疗与HCV蛋白酶相关的病症的方法。
-
2.Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties 失效
标题翻译: 丙型肝炎病毒的大环NS-3丝氨酸蛋白酶抑制剂包含烷基和芳基丙氨酸P2部分公开(公告)号:US06914122B2
公开(公告)日:2005-07-05
申请号:US09836636
申请日:2001-04-17
申请人: Srikanth Venkatraman , Kevin X. Chen , Ashok Arasappan , F. George Njoroge , Viyyoor Moopil Girijavallabhan , Ashit K. Ganguly , Tin-Yau Chan , Brian Alexander Mc Kittrick , Nanhua Hugh Yao , Andrew Joseph Prongay , Vincent Stewart Madison
发明人: Srikanth Venkatraman , Kevin X. Chen , Ashok Arasappan , F. George Njoroge , Viyyoor Moopil Girijavallabhan , Ashit K. Ganguly , Tin-Yau Chan , Brian Alexander Mc Kittrick , Nanhua Hugh Yao , Andrew Joseph Prongay , Vincent Stewart Madison
IPC分类号: A61K45/00 , A61K31/7052 , A61K38/00 , A61K38/21 , A61P31/12 , A61P31/14 , A61P43/00 , C07D273/00 , C07K5/02 , C07K7/02 , C07K7/64 , C07K7/50
CPC分类号: C07K5/0202 , A61K38/00 , C07K7/02
摘要: The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型大环化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这种大环化合物的药物组合物以及使用它们治疗与HCV蛋白酶相关的病症的方法。
-