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1.
公开(公告)号:US07449447B2
公开(公告)日:2008-11-11
申请号:US10925329
申请日:2004-08-24
申请人: Kevin X. Chen , F. George Njoroge , Weiying Yang , Bancha Vibulbhan , Viyyoor M. Girijavallabhan , Srikanth Venkatraman , Francisco Velazquez
发明人: Kevin X. Chen , F. George Njoroge , Weiying Yang , Bancha Vibulbhan , Viyyoor M. Girijavallabhan , Srikanth Venkatraman , Francisco Velazquez
IPC分类号: A61K38/06 , C07K5/08 , C07D209/02
CPC分类号: C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/021 , C07K5/0827 , C07K7/06
摘要: The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: useful in the treatment or prevention or amelioration of one or more symptoms of hepatitis C.
摘要翻译: 本申请公开了所述化合物或所述前药的药学上可接受的盐或溶剂化物的化合物或其对映异构体,立体异构体,旋转异构体,互变异构体,前体药物,所述化合物具有式1所示的一般结构:有用的 治疗或预防或改善一种或多种丙型肝炎症状。
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2.Ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus 失效
标题翻译: 具有环状P4的酮酰胺作为丙型肝炎病毒的NS3丝氨酸蛋白酶的抑制剂公开(公告)号:US07619094B2
公开(公告)日:2009-11-17
申请号:US11602174
申请日:2006-11-20
申请人: Kevin X Chen , F George Njoroge , Mousumi Sannigrahi , Latha G Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
发明人: Kevin X Chen , F George Njoroge , Mousumi Sannigrahi , Latha G Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
IPC分类号: C07D209/02 , C07D403/12 , A61K31/403
CPC分类号: C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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3.Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus 有权
标题翻译: 具有环状P4'S的酮酰胺作为丙型肝炎病毒NS3蛋白酶的抑制剂公开(公告)号:US07173057B2
公开(公告)日:2007-02-06
申请号:US11065647
申请日:2005-02-24
申请人: Kevin X. Chen , F. George Njoroge , Mousumi Sannigrahi , Latha G. Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
发明人: Kevin X. Chen , F. George Njoroge , Mousumi Sannigrahi , Latha G. Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
IPC分类号: A61K31/4035 , A61K31/403 , A61K31/407 , A61K31/454 , A61K31/5355 , A61K31/4725 , A61K31/4166 , C07D209/48 , C07D209/52 , C07D209/02 , C07D471/02 , C07D401/12 , C07D413/12 , C07D217/24 , C07D233/02 , C07D233/74
CPC分类号: C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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4.
公开(公告)号:US08143305B2
公开(公告)日:2012-03-27
申请号:US12675897
申请日:2008-08-27
申请人: Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
发明人: Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
IPC分类号: A01N43/38 , A61K31/40 , C07D209/04
CPC分类号: C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要: The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译: 本发明涉及2,3-取代的吲哚衍生物,包含至少一种2,3-取代的吲哚衍生物的组合物和使用2,3-取代的吲哚衍生物用于治疗或预防病毒感染或病毒相关的方法 病人无序。
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5.
公开(公告)号:US20110033417A1
公开(公告)日:2011-02-10
申请号:US12675897
申请日:2008-08-27
申请人: Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
发明人: Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
IPC分类号: A61K38/21 , C07D401/04 , C07D413/14 , C07D209/42 , C07D401/14 , C07D417/14 , C07D407/14 , C07D409/14 , A61K31/4439 , A61K31/444 , A61K31/404 , A61K31/4545 , A61K31/513 , A61K31/443 , A61K31/4709 , A61K31/4436 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/7088 , A61K31/7052 , A61K39/12 , A61K39/42 , A61P31/12 , A61P31/14
CPC分类号: C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要: The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译: 本发明涉及2,3-取代的吲哚衍生物,包含至少一种2,3-取代的吲哚衍生物的组合物和使用2,3-取代的吲哚衍生物用于治疗或预防病毒感染或病毒相关的方法 病人无序。
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公开(公告)号:US08901139B2
公开(公告)日:2014-12-02
申请号:US12997654
申请日:2009-06-10
申请人: Srikanth Venkatraman , Anilkumar Gopinadhan Nair , Kevin X. Chen , Francisco Velazquez , Qingbei Zeng , Duan Liu , Yueheng Jiang , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Stephen J. Gavalas , Patrick A. Pinto , Oleg B. Selyutin , Bancha Vibulbhan
发明人: Srikanth Venkatraman , Anilkumar Gopinadhan Nair , Kevin X. Chen , Francisco Velazquez , Qingbei Zeng , Duan Liu , Yueheng Jiang , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Stephen J. Gavalas , Patrick A. Pinto , Oleg B. Selyutin , Bancha Vibulbhan
IPC分类号: C07D491/04 , C07D519/00 , C07D491/048 , A61K31/517 , A61P31/12 , C07D401/14
CPC分类号: C07D491/048 , C07D491/04 , C07D519/00
摘要: The present invention relates to Tricyclic Indole Derivatives, compositions comprising at least one Tricyclic Indole Derivatives, and methods of using the Tricyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译: 本发明涉及三环吲哚衍生物,包含至少一种三环吲哚衍生物的组合物,以及使用三环吲哚衍生物治疗或预防患者病毒感染或病毒相关病症的方法。
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7.Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease 有权
标题翻译: 硫化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号:US08067379B2
公开(公告)日:2011-11-29
申请号:US11064673
申请日:2005-02-24
申请人: Frank Bennett , Raymond G. Lovey , Yuhua Huang , Siska Hendrata , Anil K. Saksena , Stephane L. Bogen , Yi-Tsung Liu , F. George Njoroge , Srikanth Venkatraman , Kevin X. Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor M. Girijavallabhan , Francisco Velazquez , Latha G. Nair
发明人: Frank Bennett , Raymond G. Lovey , Yuhua Huang , Siska Hendrata , Anil K. Saksena , Stephane L. Bogen , Yi-Tsung Liu , F. George Njoroge , Srikanth Venkatraman , Kevin X. Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor M. Girijavallabhan , Francisco Velazquez , Latha G. Nair
IPC分类号: A61K38/06
CPC分类号: C07D209/52 , A61K38/00 , C07D207/16 , C07D209/56 , C07D405/12 , C07D409/12 , C07D411/12 , C07D491/04 , C07K5/0202
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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8.Diaryl peptides as NS3-serine protease inhibitors of hepatitis C virus 失效
标题翻译: 二芳基肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂公开(公告)号:US06911428B2
公开(公告)日:2005-06-28
申请号:US10013071
申请日:2001-12-10
申请人: Zhaoning Zhu , Zhong-Yue Sun , Srikanth Venkatraman , F. George Njoroge , Ashok Arasappan , Bruce A. Malcolm , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Kevin X. Chen
发明人: Zhaoning Zhu , Zhong-Yue Sun , Srikanth Venkatraman , F. George Njoroge , Ashok Arasappan , Bruce A. Malcolm , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Kevin X. Chen
IPC分类号: C12N9/99 , A61K31/7042 , A61K38/00 , A61K38/21 , A61K45/00 , A61P31/12 , A61P31/14 , A61P43/00 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/00 , C07K14/81 , A61K38/17 , A61K31/33 , C07K7/64
CPC分类号: C07K5/0202 , A61K38/00 , C07K14/811
摘要: The present invention is directed to certain diaryl amide compounds as NS3-Serine protease inhibitors of hepatitis C virus. A particularly preferred compound is of the formula:
摘要翻译: 本发明涉及某些二芳基酰胺化合物作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂。 特别优选的化合物具有下式:
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9.
公开(公告)号:US20110150835A1
公开(公告)日:2011-06-23
申请号:US11931408
申请日:2007-10-31
申请人: Srikanth Venkatraman , F. George Njoroge , Wanli Wu , Viyyoor M. Girijavallabhan , Brian A. McKittrick , Jing Su , Francisco Velazquez , Patrick A. Pinto
发明人: Srikanth Venkatraman , F. George Njoroge , Wanli Wu , Viyyoor M. Girijavallabhan , Brian A. McKittrick , Jing Su , Francisco Velazquez , Patrick A. Pinto
IPC分类号: A61K38/21 , C07D491/044 , A61K31/454 , A61K31/7056 , A61K31/55 , A61K31/496 , A61K31/407 , A61K31/38 , A61K31/541 , C07D487/04 , A61K31/427 , A61P31/14
CPC分类号: A61K31/541 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/55 , A61K38/21 , A61K45/06 , C07K5/06026 , C07K5/0606 , C07K5/06069 , A61K2300/00
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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10.3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease 失效
标题翻译: 3,4-(环戊基) - 脯氨酸化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号:US07342041B2
公开(公告)日:2008-03-11
申请号:US11064757
申请日:2005-02-24
申请人: F. George Njoroge , Srikanth Venkatraman , Ashok Arasappan , Francisco Velazquez , Viyyoor M. Girijavallabhan
发明人: F. George Njoroge , Srikanth Venkatraman , Ashok Arasappan , Francisco Velazquez , Viyyoor M. Girijavallabhan
IPC分类号: A61K31/401 , C07D207/08
CPC分类号: C07K5/0202
摘要: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译: 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中,本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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