公开(公告)号：US06703528B2

公开(公告)日：2004-03-09

申请号：US09925523

申请日：2001-08-10

申请人： Koji Hagiya ,  Naoyuki Takano ,  Akio Kurihara

发明人： Koji Hagiya ,  Naoyuki Takano ,  Akio Kurihara

IPC分类号： C07C4500

CPC分类号： C07C409/14 ,  B01J21/02 ,  B01J23/28 ,  B01J23/30 ,  C07B41/00 ,  C07C29/03 ,  C07C45/28 ,  C07C45/294 ,  C07C45/53 ,  C07C49/258 ,  C07C51/31 ,  C07C67/31 ,  C07C67/333 ,  C07C407/00 ,  C07C409/04 ,  C07C2601/02 ,  C07C2602/20 ,  C07C59/347 ,  C07C55/14 ,  C07C69/757 ,  C07C35/28

摘要： There are disclosed are a method for producing at least one compound selected from a carbonyl compound and a hydroxy adduct compound by an oxidative cleavage or addition reaction of an olefinic double bond of an olefin compound, which contains reacting an olefin compound with hydrogen peroxide, utilizing as a catalyst, at least one member selected from (a) tungsten, (b) molybdenum, or (c) a tungsten or molybdenum metal compound containing (ia) tungsten or (ib) molybdenum and (ii) an element of Group IIIb, IVb, Vb or VIb excluding oxygen, and a catalyst composition.

摘要翻译： 公开了通过烯烃化合物的烯烃双键的氧化裂解或加成反应来生产选自羰基化合物和羟基加合物的至少一种化合物的方法，所述烯烃化合物含有使烯烃化合物与过氧化氢反应的烯烃双键，利用asa 催化剂，选自（a）钨，（b）钼或（c）含有（ia）钨或（ib）钼的钨或钼金属化合物和（ii）IIIb族，IVb族元素的至少一种， Vb或VIb除外，还有催化剂组成。

公开(公告)号：US20060089506A1

公开(公告)日：2006-04-27

申请号：US10549310

申请日：2004-03-24

申请人： Naoyuki Takano ,  Koji Hagiya

发明人： Naoyuki Takano ,  Koji Hagiya

IPC分类号： C07C69/74 ,  C07F9/94

CPC分类号： C07D317/54 ,  C07C45/30 ,  C07C67/333 ,  C07C69/757

摘要： There is provided a process for the production of carbonyl compounds, characterized by reacting a diol represented by the formula (1); wherein R1, R2, R3 and R4 are the same or different, and independently represent a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted acyl group, a substituted or unsubstituted alkoxycarbonyl group, a substituted or unsubstituted aryloxycarbonyl group, a substituted or unsubstituted aralkyloxycarbonyl group, carboxyl group or a hydrogen atom, or R1 and R2 or R3 and R4 are bonded together with the carbon atoms to which they are bonded to form a ring, provided that all of R1, R2, R3 and R4 are not hydrogen atoms simultaneously; with bromine or an inorganic bromine compound in the presence of a trivalent bismuth compound and a base to form carbonyl compounds represented by the formula (2); wherein R1 and R3 are as defined above; and the formula (3); wherein R2 and R4 are as defined above.

摘要翻译： 提供了一种制备羰基化合物的方法，其特征在于使由式（1）表示的二醇反应; 其中R 1，R 2，R 3和R 4相同或不同，并且独立地表示 取代或未取代的烷基，取代或未取代的芳基，取代或未取代的芳烷基，取代或未取代的酰基，取代或未取代的烷氧基羰基，取代或未取代的芳氧基羰基，取代或未取代的芳烷氧基羰基，羧基 或者氢原子，或者R 1和R 2或R 3和R 4是与 与它们键合的碳原子形成环，条件是R 1，R 2，R 3和R' 4不同时为氢原子; 与溴或无机溴化合物在三价铋化合物和碱的存在下反应形成由式（2）表示的羰基化合物; 其中R 1和R 3如上定义; 和式（3）; 其中R 2和R 4如上定义。

公开(公告)号：US07304185B2

公开(公告)日：2007-12-04

申请号：US10549310

申请日：2004-03-24

申请人： Naoyuki Takano ,  Koji Hagiya

发明人： Naoyuki Takano ,  Koji Hagiya

IPC分类号： C07C67/313 ,  C07C69/757 ,  C07D317/54

CPC分类号： C07D317/54 ,  C07C45/30 ,  C07C67/333 ,  C07C69/757

摘要： There is provided a process for the production of carbonyl compounds, characterized by reacting a diol represented by the formula (1); wherein R1, R2, R3 and R4 are the same or different, and independently represent a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted acyl group, a substituted or unsubstituted alkoxycarbonyl group, a substituted or unsubstituted aryloxycarbonyl group, a substituted or unsubstituted aralkyloxycarbonyl group, carboxyl group or a hydrogen atom, or R1 and R2 or R3 and R4 are bonded together with the carbon atoms to which they are bonded to form a ring, provided that all of R1, R2, R3 and R4 are not hydrogen atoms simultaneously; with bromine or an inorganic bromine compound in the presence of a trivalent bismuth compound and a base to form carbonyl compounds represented by the formula (2); wherein R1 and R3 are as defined above; and the formula (3); wherein R2 and R4 are as defined above.

摘要翻译： 提供了一种生产羰基化合物的方法，其特征在于使由式（1）表示的二醇反应;

公开(公告)号：US06489505B2

公开(公告)日：2002-12-03

申请号：US09769290

申请日：2001-01-26

申请人： Koji Hagiya ,  Ichiro Komoto ,  Akio Kurihara

发明人： Koji Hagiya ,  Ichiro Komoto ,  Akio Kurihara

IPC分类号： C07C6966

CPC分类号： C07C67/333 ,  C07C69/757

摘要： There is provided a process for producing 3,3-dimethyl-2-formylcyclopropanecarboxylic ester of formula (1): wherein R represents an alkyl group, a cycloalkyl group or an optionally substituted aralkyl group, which comprises reacting chrysanthemic acid ester of formula (2): wherein R represents the same meaning as that described above, with hydrogen peroxide in the presence of at least one catalyst selected from tungstic oxide, tungstic acid, tugstate, alkylrhenium trioxide, molybdic oxide, molybdate, a heteropoly acid comprising a hetero atom selected from a phosphorus, boron or silicone atom and a poly atom selected from tungsten or molybdenum and a salt of said heteropoly acid.

摘要翻译： 提供了一种制备式（1）的3,3-二甲基-2-甲酰基环丙烷羧酸酯的方法：其中R代表烷基，环烷基或任意取代的芳烷基，其包括使式（2）的菊酸酯与 ）：其中R表示与上述相同的含义，过氧化氢在至少一种选自氧化钨，钨酸，钨酸盐，三氧化锑，氧化钼，钼酸盐，包含选择的杂原子的杂多酸的催化剂存在下存在 从磷，硼或硅酮原子和选自钨或钼的聚原子和所述杂多酸的盐。

公开(公告)号：US08604221B2

公开(公告)日：2013-12-10

申请号：US13265699

申请日：2010-05-19

申请人： Koji Hagiya ,  Yasutaka Aoyagi

发明人： Koji Hagiya ,  Yasutaka Aoyagi

IPC分类号： C07D305/12

CPC分类号： C07D307/88 ,  C07B31/00 ,  C07D307/89

摘要： Disclosed is a method for producing a halogen-substituted phthalide, which includes a reaction step of reacting a halogen-substituted phthalic anhydride with sodium borohydride.

摘要翻译： 公开了一种制备卤素取代的苯酞的方法，其包括使卤素取代的邻苯二甲酸酐与硼氢化钠反应的反应步骤。

公开(公告)号：US20130137897A1

公开(公告)日：2013-05-30

申请号：US13816123

申请日：2011-08-26

申请人： Kazuyasu Tani ,  Taro Hirose ,  Koji Hagiya

发明人： Kazuyasu Tani ,  Taro Hirose ,  Koji Hagiya

IPC分类号： C07C319/20

CPC分类号： C07C319/20 ,  B01J31/2243 ,  B01J2231/70 ,  B01J2531/0241 ,  B01J2531/0252 ,  B01J2531/56 ,  C07C323/52

摘要： The present invention provides a novel process for preparing a sulfur-containing 2-ketocarboxylate compound without using any enzyme. The process comprises a step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position in the presence of a vanadium compound. Preferably, the step is carried out further in the presence of oxygen, and more preferably, in the presence of an organic solvent.

摘要翻译： 本发明提供了一种不使用任何酶制备含硫的2-酮羧酸盐化合物的新方法。 该方法包括在钒化合物的存在下，在2-位氧化具有任选取代的含硫烃基的羟基乙酸酯化合物的步骤。 优选地，该步骤在氧的存在下进一步进行，更优选在有机溶剂的存在下进行。

公开(公告)号：US08399710B2

公开(公告)日：2013-03-19

申请号：US12675042

申请日：2008-08-27

申请人： Koji Hagiya

发明人： Koji Hagiya

IPC分类号： C07C45/90

CPC分类号： C07B39/00 ,  C01D3/02 ,  C07C17/208 ,  C07C51/00 ,  C07C51/58 ,  C07C51/60 ,  C07C67/14 ,  C07C201/12 ,  C07C63/30 ,  C07C69/76 ,  C07C205/12

摘要： An alkali metal fluoride dispersion of an alkali metal fluoride and an aprotic organic solvent is obtainable by (A) separating a liquid phase from an alkali metal fluoride dispersion comprising an alcohol solvent and an alkali metal fluoride, and mixing the separated liquid phase with an aprotic organic solvent having a boiling point of 85° C. or higher at normal pressure; (B) obtaining a mixture containing the alkali metal fluoride by (b1) concentrating the mixture containing the alkali metal fluoride to obtain a concentrated fraction and a concentrated residue; (b2) mixing a residue of the alkali metal fluoride dispersion with the concentrated fraction obtained in (b1); and (b3) separating a liquid phase from the mixture containing an alkali metal fluoride obtained in (b2) and mixing the separated liquid phase with the concentrated residue; and (C) removing the alcohol solvent from the mixture containing the alkali metal fluoride.

摘要翻译： 碱金属氟化物和非质子性有机溶剂的碱金属氟化物分散体可以通过（A）从包含醇溶剂和碱金属氟化物的碱金属氟化物分散液中分离液相，并将分离的液相与非质子 常压下沸点为85℃以上的有机溶剂; （B）通过（b1）浓缩含有碱金属氟化物的混合物得到含有碱金属氟化物的混合物，得到浓缩馏分和浓缩残渣; （b2）将碱金属氟化物分散体的残渣与（b1）中得到的浓缩馏分混合; 和（b3）从含有（b2）中得到的碱金属氟化物的混合物中分离液相并将分离的液相与浓缩残余物混合; 和（C）从含有碱金属氟化物的混合物中除去醇溶剂。

公开(公告)号：US20130023696A1

公开(公告)日：2013-01-24

申请号：US13639210

申请日：2011-04-05

申请人： Koji Hagiya

发明人： Koji Hagiya

IPC分类号： C07C51/305

CPC分类号： C07C319/20 ,  C07C323/58

摘要： The present invention relates to a process for producing a sulfur-containing amino acid, comprising a step of oxidizing a 2-aminoethanol compound having, at position 2, a sulfur-containing hydrocarbon group having 1 to 24 carbon atoms in the presence of copper and water.

摘要翻译： 本发明涉及一种生产含硫氨基酸的方法，包括在铜的存在下氧化在2位具有1至24个碳原子的含硫烃基的2-氨基乙醇化合物的步骤，和 水。

公开(公告)号：US08071805B2

公开(公告)日：2011-12-06

申请号：US12309470

申请日：2007-07-20

申请人： Koji Hagiya

发明人： Koji Hagiya

IPC分类号： C07C323/00 ,  C07C51/00 ,  C07C319/00

CPC分类号： C07C319/20 ,  C07C323/22 ,  C07C323/52

摘要： A process for producing a 2-hydroxy-4-(methylthio)butyrate compound represented by the formula (2): wherein A is a hydrogen atom or a group represented by R—CH2—, wherein R is a hydrogen atom or an alkyl group, which comprises the step of: reacting 4-(methylthio)-2-oxo-1-butanol with oxygen and a compound represented by the formula (1): A-OH  (1) wherein A is as defined above, in the presence of a copper compound.

摘要翻译： 一种制备由式（2）表示的2-羟基-4-（甲硫基）丁酸酯化合物的方法：其中A是氢原子或由R-CH2-表示的基团，其中R是氢原子或烷基 ，其包括以下步骤：使4-（甲硫基）-2-氧代-1-丁醇与氧和由式（1）表示的化合物反应：A-OH（1）其中A如上定义，在存在下 的铜化合物。

公开(公告)号：US08039680B2

公开(公告)日：2011-10-18

申请号：US12525913

申请日：2009-02-14

申请人： Koji Hagiya

发明人： Koji Hagiya

IPC分类号： C07C33/46

CPC分类号： C07C29/62 ,  C07C29/147 ,  C07C29/58 ,  C07C51/363 ,  C07C67/14 ,  C07C33/46 ,  C07C63/68 ,  C07C69/76

摘要： A process for producing 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol including the following steps: (A): a step for fluorinating 2,3,5,6-tetrachloroterephthaloyl dichloride, (B): a step for reducing the product obtained in step (A), (C): a step for chlorinating the product obtained in step (B), and Step (D): a step for hydrogenating the product obtained in step (C).

摘要翻译： 包括以下步骤的制备4-甲基-2,3,5,6-四氟苄醇的方法：（A）：用于氟化2,3,5,6-四氯对苯二甲酰氯的步骤，（B）：还原步骤 在步骤（A），（C）中获得的产物：步骤（B）中获得的产物的氯化步骤和步骤（D）：步骤（C）中获得的产物氢化步骤。