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    Nucleotide primer set and nucleotide probe for detecting genotype of N-acetyltransferase-2 (NAT2)
    4.
    发明授权
    Nucleotide primer set and nucleotide probe for detecting genotype of N-acetyltransferase-2 (NAT2) 失效
    用于检测N-乙酰转移酶-2（NAT2）基因型的核苷酸引物组和核苷酸探针

    公开(公告)号：US07919611B2

    公开(公告)日：2011-04-05

    申请号：US12014592

    申请日：2008-01-15

    申请人： Naoko Nakamura ,  Keiko Ito ,  Koji Hashimoto ,  Nobuhiro Gemma

    发明人： Naoko Nakamura ,  Keiko Ito ,  Koji Hashimoto ,  Nobuhiro Gemma

    IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： There is provided a nucleotide primer set for LAMP amplification, used for detecting genotypes of single-nucleotide polymorphisms G590A, G857A and T341C of a NAT2 gene. There is also provided a nucleotide probe for detection of an amplification product amplified with the primer set according to the present invention. There is also provided a method of detecting the genotypes of NAT2 gene single-nucleotide polymorphisms G590A, G857A and T341C by using the primer set according to the present invention.

    摘要翻译： 提供了LAMP扩增的核苷酸引物组，用于检测NAT2基因的单核苷酸多态性G590A，G857A和T341C的基因型。 还提供了用于检测根据本发明的引物组扩增的扩增产物的核苷酸探针。 还提供了通过使用本发明的引物组来检测NAT2基因单核苷酸多态性G590A，G857A和T341C的基因型的方法。

    NUCLEOTIDE PRIMER SET AND NUCLEOTIDE PROBE FOR DETECTING GENOTYPE OF N-ACETYLTRANSFERASE-2 (NAT2)
    5.
    发明申请
    NUCLEOTIDE PRIMER SET AND NUCLEOTIDE PROBE FOR DETECTING GENOTYPE OF N-ACETYLTRANSFERASE-2 (NAT2) 失效
    用于检测N-乙酰基转移酶-2（NAT2）基因组的核酸酶基因组和核酸探针

    公开(公告)号：US20100003671A1

    公开(公告)日：2010-01-07

    申请号：US12014592

    申请日：2008-01-15

    申请人： Naoko Nakamura ,  Keiko Ito ,  Koji Hashimoto ,  Nobuhiro Gemma

    发明人： Naoko Nakamura ,  Keiko Ito ,  Koji Hashimoto ,  Nobuhiro Gemma

    IPC分类号： C12Q1/68 ,  C07H21/00

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： There is provided a nucleotide primer set for LAMP amplification, used for detecting genotypes of single-nucleotide polymorphisms G590A, G857A and T341C of a NAT2 gene. There is also provided a nucleotide probe for detection of an amplification product amplified with the primer set according to the present invention. There is also provided a method of detecting the genotypes of NAT2 gene single-nucleotide polymorphisms G590A, G857A and T341C by using the primer set according to the present invention.

    摘要翻译： 提供了LAMP扩增的核苷酸引物组，用于检测NAT2基因的单核苷酸多态性G590A，G857A和T341C的基因型。 还提供了用于检测根据本发明的引物组扩增的扩增产物的核苷酸探针。 还提供了通过使用本发明的引物组来检测NAT2基因单核苷酸多态性G590A，G857A和T341C的基因型的方法。

    DETECTION OF NUCLEIC ACID ASSOCIATED WITH DISEASE
    9.
    发明申请
    DETECTION OF NUCLEIC ACID ASSOCIATED WITH DISEASE 审中-公开
    检测与疾病相关的核酸

    公开(公告)号：US20080166710A1

    公开(公告)日：2008-07-10

    申请号：US11692837

    申请日：2007-03-28

    申请人： Koji Hashimoto ,  Michie Hashimoto ,  Shunji Mishiro ,  Yasuhiko Oota

    发明人： Koji Hashimoto ,  Michie Hashimoto ,  Shunji Mishiro ,  Yasuhiko Oota

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/701

    摘要： The present invention provides methods for obtaining information regarding nucleic acid from an individual and nucleic acid associated with a disease of the individual, in particular when the disease is associated with a pathogenic microorganism present within the individual. The present invention also provide probe-immobilized substrates, such as probe-immobilized chips, for use in the methods. In particular, the present invention provides methods and probe-immobilized substrates for obtaining information regarding responsiveness to a treatment for a disease of an individual.

    摘要翻译： 本发明提供了获得关于来自个体的核酸的信息和与个体的疾病相关的核酸的信息的方法，特别是当疾病与个体内存在的病原微生物相关时。 本发明还提供了用于该方法的探针固定的基底，例如探针固定的碎片。 特别地，本发明提供了用于获得关于对个体疾病的治疗的反应性的信息的方法和探针固定的基质。

    Method of detecting target nucleotide sequence, structure and preparation of the detection target used for working the detection method, and assay kit for detecting the target nucleotide sequence
    10.
    发明申请
    Method of detecting target nucleotide sequence, structure and preparation of the detection target used for working the detection method, and assay kit for detecting the target nucleotide sequence 审中-公开
    检测目标核苷酸序列的方法，用于检测方法的检测对象的结构和制备方法以及检测靶核苷酸序列的检测试剂盒

    公开(公告)号：US20060099615A1

    公开(公告)日：2006-05-11

    申请号：US11230627

    申请日：2005-09-21

    申请人： Hideki Horiuchi ,  Koji Hashimoto

    发明人： Hideki Horiuchi ,  Koji Hashimoto

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6813 ,  C12Q2521/319 ,  C12Q2525/186 ,  C12Q2533/101 ,  C12Q2537/163

    摘要： The present invention provides a method of preparing a detection target structure useful for detecting a target nucleotide sequence. For example, provided is a method of preparing a detection target structure from a target nucleic acid (1). The target nucleic acid includes a target nucleotide sequence 2 in a part. According to the method of the present invention, a nucleic acid is elongated by using a primer so as to permit the target nucleic acid to have a double strand structure in the portion other than the target nucleotide sequence 2, thereby affording a detection target structure 4. The present invention also provides the detection target structure thus prepared a detection method of the target nucleotide sequence by using the detection target structure, a kit for preparing the detection target structure, and an assay kit for detecting the target nucleotide sequence.

    摘要翻译： 本发明提供了制备用于检测靶核苷酸序列的检测靶结构的方法。 例如，提供从靶核酸（1）制备检测靶结构的方法。 靶核酸部分包含靶核苷酸序列2。 根据本发明的方法，通过使用引物使核酸伸长，以使靶核酸在靶核苷酸序列2以外的部分具有双链结构，由此提供检测目标结构4 本发明还提供了通过使用检测对象结构制备靶核苷酸序列的检测方法的检测对象结构，用于制备检测对象结构的试剂盒和检测靶核苷酸序列的检测试剂盒。