公开(公告)号：US20020161134A1

公开(公告)日：2002-10-31

申请号：US09778081

申请日：2001-02-07

Applicant: Korea Institute of Science and Technology

Inventor： Young Ha Kim ,  Soo Hyun Kim ,  Ki Dong Park ,  Soo-Hong Lee

IPC: C08G065/32 ,  C08F283/06 ,  C08G063/91 ,  C08G063/66 ,  C08G063/664 ,  C08L067/00 ,  C08L067/04 ,  C08L071/00 ,  C08L071/02 ,  C08G063/00

CPC classification number: C08G65/3324 ,  C08G63/664 ,  C08L71/02 ,  C08L2666/18

Abstract: The present invention relates to polyethyleneglycol/polylactide (or polyglycolide or polycaprolactone)/polyethyleneglycol triblock copolymers with an enhanced reactivity, and process for their preparation. More specifically, the present invention is directed to triblock copolymers that are obtained by the process comprising the step of synthesizing a polylactide (or polyglycolide or polycaprolactone) having hydroxy groups at both ends and the step of coupling said polylactide with polyethyleneglycol having an acylhalide group of a high reactivity at one of its ends, and the process for preparing the same. Since the triblock copolymer according to the present invention has an ester structure with good biocompatibility, it can be applied extensively for biomaterials used in tissue engineering, in a matrix that slowly releases drugs, etc.

Abstract translation: 本发明涉及具有增强反应性的聚乙二醇/聚丙交酯（或聚乙交酯或聚己内酯）/聚乙二醇三嵌段共聚物及其制备方法。 更具体地说，本发明涉及三嵌段共聚物，该三嵌段共聚物通过包括以下步骤获得的方法：合成在两端具有羟基的聚丙交酯（或聚乙交酯或聚己内酯）和将所述聚交酯与具有酰卤基团的聚乙二醇 其一端的高反应性及其制备方法。 由于本发明的三嵌段共聚物具有良好的生物相容性的酯结构，因此可广泛用于组织工程中使用的生物材料，缓慢释放药物等的基质。