公开(公告)号：US20060078931A1

公开(公告)日：2006-04-13

申请号：US11245348

申请日：2005-10-06

申请人： Kwang-wook Oh ,  Yu-jin Seo ,  Gyeong-sik Ok ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

发明人： Kwang-wook Oh ,  Yu-jin Seo ,  Gyeong-sik Ok ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： B01L3/502715 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2400/065

摘要： Provided is a microchip unit, including a microchip on which a plurality of micro-channels are formed, a housing disposed below the microchip to fix the microchip; and at least two injecting and sealing elements having through-holes corresponding to inlets of the microchip. The injecting and sealing elements are vertically fixed on the top of the housing and slide in a horizontal direction from a first location to a second location and vice versa. The through-holes are aligned with inlets of the microchip so that a reaction solution can be injected through the through-holes when the injecting and sealing elements are placed at the first location. The inlets of the microchip are sealed by elastic members formed on bottom surfaces of the injecting and sealing elements when the injecting and sealing elements are placed at the second location.

摘要翻译： 提供一种微芯片单元，其包括形成有多个微通道的微芯片，设置在微芯片下面以固定微芯片的壳体; 以及至少两个具有对应于微芯片的入口的通孔的注入和密封元件。 注射和密封元件垂直地固定在壳体的顶部上，并且在从第一位置到第二位置的水平方向上滑动，反之亦然。 通孔与微芯片的入口对准，使得当注射和密封元件放置在第一位置时，反应溶液可以通过通孔注入。 当注射和密封元件放置在第二位置时，微芯片的入口由形成在注射和密封元件的底表面上的弹性构件密封。

公开(公告)号：US07754452B2

公开(公告)日：2010-07-13

申请号：US11377793

申请日：2006-03-16

申请人： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chin-sung Park ,  Yu-jin Seo

发明人： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chin-sung Park ,  Yu-jin Seo

IPC分类号： C12P19/34 ,  C12M1/36 ,  G01N15/06

CPC分类号： B01L7/52 ,  B01L3/5027 ,  B01L9/52 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686

摘要： Provided are a polymerase chain reaction (PCR) module and a PCR system including the same. The PCR module includes: a detachable PCR chip including a PCR chamber unit in which a PCR solution is accommodated; a heater unit for heating the PCR solution in the PCR chip with a preset temperature; a detecting unit for detecting a PCR signal of the PCR solution; a PCR chip installation unit for mounting/detaching the PCR chip using a one-touch method, in which the heater unit is adhered to the PCR chip with a predetermined pressure when mounting the PCR chip and the heater unit is separated from the PCR chip when detaching the PCR chip; and a housing covering at least the heater unit and the detecting unit so that they are not exposed to the outside.

摘要翻译： 提供了聚合酶链反应（PCR）模块和包括其的PCR系统。 所述PCR模块包括：可拆卸PCR芯片，其包括其中容纳PCR溶液的PCR室单元; 用于以预设温度加热PCR芯片中的PCR溶液的加热器单元; 用于检测PCR溶液的PCR信号的检测单元; 用于使用一触式方法安装/分离PCR芯片的PCR芯片安装单元，其中当将PCR芯片和加热器单元安装在PCR芯片上时，将加热器单元以预定的压力粘附到PCR芯片上，与PCR芯片分离， 分离PCR芯片; 以及至少覆盖加热器单元和检测单元的壳体，使得它们不暴露于外部。

公开(公告)号：US20060246580A1

公开(公告)日：2006-11-02

申请号：US11377793

申请日：2006-03-16

申请人： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chi-sung Park ,  Yu-jin Seo

发明人： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chi-sung Park ,  Yu-jin Seo

IPC分类号： C12M1/34

CPC分类号： B01L7/52 ,  B01L3/5027 ,  B01L9/52 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686

摘要： Provided are a polymerase chain reaction (PCR) module and a PCR system including the same. The PCR module includes: a detachable PCR chip including a PCR chamber unit in which a PCR solution is accommodated; a heater unit for heating the PCR solution in the PCR chip with a preset temperature; a detecting unit for detecting a PCR signal of the PCR solution; a PCR chip installation unit for mounting/detaching the PCR chip using a one-touch method, in which the heater unit is adhered to the PCR chip with a predetermined pressure when mounting the PCR chip and the heater unit is separated from the PCR chip when detaching the PCR chip; and a housing covering at least the heater unit and the detecting unit so that they are not exposed to the outside.

摘要翻译： 提供了聚合酶链反应（PCR）模块和包括其的PCR系统。 所述PCR模块包括：可拆卸PCR芯片，其包括其中容纳PCR溶液的PCR室单元; 用于以预设温度加热PCR芯片中的PCR溶液的加热器单元; 用于检测PCR溶液的PCR信号的检测单元; 用于使用一触式方法安装/分离PCR芯片的PCR芯片安装单元，其中当将PCR芯片和加热器单元安装在PCR芯片上时，将加热器单元以预定的压力粘附到PCR芯片上，与PCR芯片分离， 分离PCR芯片; 以及至少覆盖加热器单元和检测单元的壳体，使得它们不暴露于外部。

公开(公告)号：US07413707B2

公开(公告)日：2008-08-19

申请号：US11430741

申请日：2006-05-09

申请人： Kwang-wook Oh ,  Yu-jin Seo

发明人： Kwang-wook Oh ,  Yu-jin Seo

IPC分类号： B01D59/44

CPC分类号： B01L3/502715 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/043 ,  B01L2300/0816 ,  B01L2400/0406 ,  G01N2035/00158

摘要： Provided is a microchip assembly including a base holder, a microchip installed on the base holder and having at least one input hole into which a reaction sample is input and at least one microchamber accommodating the input reaction sample, a flipper rotatably installed at the outside of the microchip on the base holder and opening and closing the input hole of the microchip while flipping up in a vertically erected state or flipping down in a horizontal state, and slider installed at the outside of the flipper on the base holder to be capable of sliding and supporting the flipper in the erected state and flipping down the flipper while moving inside.

摘要翻译： 提供了一种微芯片组件，其包括基座，安装在基座上的微芯片，并具有输入反应样品的至少一个输入孔和容纳该输入反应样品的至少一个微室， 该微型芯片位于基座上，并且在垂直竖立状态下翻转或以水平状态翻转时打开和关闭微芯片的输入孔，以及滑块安装在底架上的导板外侧以能够滑动 并且在竖立状态下支撑导板，并在向内移动的情况下翻转导板。

公开(公告)号：US20060246487A1

公开(公告)日：2006-11-02

申请号：US11391850

申请日：2006-03-29

申请人： Kwang-wook Oh ,  Yu-jin Seo

发明人： Kwang-wook Oh ,  Yu-jin Seo

IPC分类号： C12Q1/68

CPC分类号： B01L3/502715 ,  B01L3/565 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2400/065

摘要： Provided is an apparatus for performing a chemical reaction using a microchip having at least one micro-channel. The device, which is a semiautomatic operating device for a microchip on which at least one micro-channel with a reagent inlet is formed, includes: a base which accommodates the microchip; a slider with injection inlets corresponding to the reagent inlets that reciprocally move parallel to the base; and a slider moving unit which selectively moves the slider to a first location at which the microchip is opened, after the injection inlet of the slider and the reagent inlet are aligned, and to a second location where the microchip is sealed by a bottom surface of the slider covering the reagent inlet.

摘要翻译： 提供一种使用具有至少一个微通道的微芯片进行化学反应的装置。 该装置是其上形成有至少一个具有试剂入口的微通道的微芯片的半自动操作装置，包括：容纳微芯片的基座; 具有与所述试剂入口相对应的注射入口的滑块，所述试剂入口与所述底座平行地往复移动; 以及滑块移动单元，其在滑块和试剂入口的注入口对齐之后，将滑块选择性地移动到微芯片打开的第一位置，并且在第二位置，微芯片被底部表面密封 滑块覆盖试剂入口。

公开(公告)号：US07892490B2

公开(公告)日：2011-02-22

申请号：US11391850

申请日：2006-03-29

申请人： Kwang-wook Oh ,  Yu-jin Seo

发明人： Kwang-wook Oh ,  Yu-jin Seo

IPC分类号： G01N21/00 ,  G01N31/00 ,  C12M1/36 ,  C12M1/38

CPC分类号： B01L3/502715 ,  B01L3/565 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2400/065

摘要： Provided is an apparatus for performing a chemical reaction using a microchip having at least one micro-channel. The device, which is a semiautomatic operating device for a microchip on which at least one micro-channel with a reagent inlet is formed, includes: a base which accommodates the microchip; a slider with injection inlets corresponding to the reagent inlets that reciprocally move parallel to the base; and a slider moving unit which selectively moves the slider to a first location at which the microchip is opened, after the injection inlet of the slider and the reagent inlet are aligned, and to a second location where the microchip is sealed by a bottom surface of the slider covering the reagent inlet.

摘要翻译： 提供一种使用具有至少一个微通道的微芯片进行化学反应的装置。 该装置是其上形成有至少一个具有试剂入口的微通道的微芯片的半自动操作装置，包括：容纳微芯片的基座; 具有与所述试剂入口相对应的注射入口的滑块，所述试剂入口与所述底座平行地往复移动; 以及滑块移动单元，其在滑块和试剂入口的注入口对齐之后，将滑块选择性地移动到微芯片打开的第一位置，并且在第二位置，微芯片被底部表面密封 滑块覆盖试剂入口。

公开(公告)号：US20060286582A1

公开(公告)日：2006-12-21

申请号：US11430741

申请日：2006-05-09

申请人： Kwang-wook Oh ,  Yu-jin Seo

发明人： Kwang-wook Oh ,  Yu-jin Seo

IPC分类号： C12Q1/68

CPC分类号： B01L3/502715 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/043 ,  B01L2300/0816 ,  B01L2400/0406 ,  G01N2035/00158

摘要： Provided is a microchip assembly including a base holder, a microchip installed on the base holder and having at least one input hole into which a reaction sample is input and at least one microchamber accommodating the input reaction sample, a flipper rotatably installed at the outside of the microchip on the base holder and opening and closing the input hole of the microchip while flipping up in a vertically erected state or flipping down in a horizontal state, and slider installed at the outside of the flipper on the base holder to be capable of sliding and supporting the flipper in the erected state and flipping down the flipper while moving inside.

摘要翻译： 提供了一种微芯片组件，其包括基座，安装在基座上的微芯片，并具有输入反应样品的至少一个输入孔和容纳该输入反应样品的至少一个微室， 该微型芯片位于基座上，并且在垂直竖立状态下翻转或以水平状态翻转时打开和关闭微芯片的输入孔，以及滑块安装在底架上的导板外侧以能够滑动 并且在竖立状态下支撑导板，并在向内移动的情况下翻转导板。

公开(公告)号：US20060193751A1

公开(公告)日：2006-08-31

申请号：US11296023

申请日：2005-12-06

申请人： Sung-ouk Jung ,  Soo-suk Lee ,  Yu-jin Seo ,  Chang-eun Yoo ,  Hun-joo Lee

发明人： Sung-ouk Jung ,  Soo-suk Lee ,  Yu-jin Seo ,  Chang-eun Yoo ,  Hun-joo Lee

IPC分类号： B01L3/00 ,  C12M1/34

CPC分类号： B01L3/508 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2300/048 ,  B01L2300/049 ,  B01L2300/0636 ,  B01L2300/0822

摘要： A packing device used to pack a sample inlet formed in an upper cover of a chamber is provided. The packing device has an air vent formed in the surface of an upper portion of the sample inlet contacting a cap or in the surface of a lower portion of the cap contacting the sample inlet. The movement of the sample solution in the chamber can be prevented by using a structural design in which air pressure generated due to the volume of a packing cap inserted into the sample inlet after the sample is injected into the chamber through the sample inlet to react with reaction materials, such as biomolecules, is not generated inside of the chamber. In addition, in a hybridization chamber in which a biochip is placed, the spot area on the biochip can be effectively agitated with the sample solution, thus increasing hybridization efficiency.

摘要翻译： 提供了用于包装形成在室的上盖中的样品入口的包装装置。 包装装置具有形成在样品入口的上部的表面中的与所述盖接触的表面或者与所述样品入口接触的所述盖的下部的表面中的通气孔。 可以通过使用结构设计来防止样品溶液在室中的移动，其中在将样品通过样品入口注入到室中之后，由于填充帽的体积而产生的空气压力插入到样品入口中，以与 在室内部不产生反应物质，如生物分子。 此外，在其中放置生物芯片的杂交室中，可以用样品溶液有效地搅拌生物芯片上的斑点区域，从而提高杂交效率。