-
公开(公告)号:US20090286843A1
公开(公告)日:2009-11-19
申请号:US12254736
申请日:2008-10-20
申请人: LAWRENCE M. BLATT , STEVEN W. ANDREWS , KEVIN R. CONDROSKI , GEORGE A. DOHERTY , YUTONG JIANG , JOHN A. JOSEY , APRIL L. KENNEDY , MACHENDER R. MADDURU , PETER J. STENGEL , STEVEN M. WENGLOWSKY , BENJAMIN T. WOODARD , LAURA WOODARD
发明人: LAWRENCE M. BLATT , STEVEN W. ANDREWS , KEVIN R. CONDROSKI , GEORGE A. DOHERTY , YUTONG JIANG , JOHN A. JOSEY , APRIL L. KENNEDY , MACHENDER R. MADDURU , PETER J. STENGEL , STEVEN M. WENGLOWSKY , BENJAMIN T. WOODARD , LAURA WOODARD
IPC分类号: A61K31/407 , C07D245/00 , A61P31/12
CPC分类号: C07K5/0804
摘要: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译: 实施方案提供了通式I-XIX的化合物,以及包含主题化合物的组合物,包括药物组合物。 实施方案还提供治疗方法,包括治疗黄病毒感染的方法,包括丙型肝炎病毒感染和治疗肝纤维化的方法,所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。