公开(公告)号：US20220349807A1

公开(公告)日：2022-11-03

申请号：US17729440

申请日：2022-04-26

Applicant: Life Technologies Corporation

Inventor： Eric Finan ,  Michael Ward

IPC: G01N15/14

Abstract: Provided are, inter alia, flow centration components that can be used in flow cytometers and other applications. A flow centrator can define central axis, a proximal end, and a distal end, and having a central bore extending within the flow centration component in the direction of the central axis; the flow centration component defining a splined outer surface that defines a plurality of circumferentially arranged bypass flute channels, the plurality of bypass flute channels extending in the direction of the central axis, and each of the bypass flute channels having a depth and a length. Also provided are related methods that utilize the disclosed components.

公开(公告)号：US10082518B2

公开(公告)日：2018-09-25

申请号：US15353828

申请日：2016-11-17

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Glen Davis ,  John Jackson ,  Gregory Kaduchak ,  Wesley Smith ,  Michael Ward

IPC: G01N15/14 ,  G01N35/10 ,  G01N35/00

CPC classification number: G01N35/1011 ,  G01N15/1404 ,  G01N35/0099

Abstract: A sampling system is provided. The sampling system includes a housing. Mounted to the housing is a Hall effect sensor. A probe configured to contact a sample is inserted into the housing. The probe includes an elongated portion and a restorative spring inserted onto the elongated portion of the probe. The restorative spring provides sufficient restorative force to return the probe to a relaxed position. The Hall effect sensor is configured to sense a field strength generated by the proximity of the restorative spring of the probe in the extended position.

公开(公告)号：US20170191922A1

公开(公告)日：2017-07-06

申请号：US15373722

申请日：2016-12-09

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael Ward ,  Jason MALKIN

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  F04B11/00 ,  F04B13/00 ,  F04B23/04 ,  F04B49/065 ,  F04B2205/05 ,  F04B2205/09 ,  F04C2/08 ,  F04C15/0049 ,  F04C28/02 ,  F04C2270/145 ,  F04C2270/185 ,  F04C2270/205 ,  F04C2270/215 ,  F04C2270/44 ,  F04C2270/80 ,  F04C2270/86 ,  F04C2270/90 ,  G01N2015/1409 ,  G05D7/0682

Abstract: An embodiment of a system with a minute measure of pulsatility in a flow of a fluid is described that comprises a first pump configured to flow the fluid to a junction at a first flow rate that comprises a measure of pulsatility; and a second pump configured to flow a portion of the fluid from the junction at a second flow rate that is less than the first flow rate to produce a flow of the fluid at a third flow rate from the junction with a minute measure of pulsatility.

公开(公告)号：US20230131332A1

公开(公告)日：2023-04-27

申请号：US18069281

申请日：2022-12-21

Applicant: Life Technologies Corporation

Inventor： Gregory Kaduchak ,  Michael Ward

IPC: G01N15/14 ,  G01N21/53 ,  G01N15/02 ,  G01N21/64 ,  G01J3/44 ,  B01L3/00

Abstract: The present disclosure provides apparatuses, systems, and methods for performing particle analysis through flow cytometry at comparatively high event rates and for gathering high resolution images of particles.

公开(公告)号：US20200088623A1

公开(公告)日：2020-03-19

申请号：US16583775

申请日：2019-09-26

Applicant: Life Technologies Corporation

Inventor： Michael Ward ,  Jason Malkin

IPC: G01N15/14 ,  G05D7/06 ,  F04B23/04 ,  F04B11/00 ,  F04B13/00 ,  F04C15/00 ,  F04B49/06 ,  F04C2/08

Abstract: An embodiment of a system with a minute measure of pulsatility in a flow of a fluid is described that comprises a first pump configured to flow the fluid to a junction at a first flow rate that comprises a measure of pulsatility; and a second pump configured to flow a portion of the fluid from the junction at a second flow rate that is less than the first flow rate to produce a flow of the fluid at a third flow rate from the junction with a minute measure of pulsatility.

公开(公告)号：US10466155B2

公开(公告)日：2019-11-05

申请号：US15373722

申请日：2016-12-09

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael Ward ,  Jason Malkin

IPC: G01N15/14 ,  F04B11/00 ,  F04B23/04 ,  G05D7/06 ,  F04B13/00 ,  F04B49/06 ,  F04C2/08 ,  F04C15/00 ,  G01N15/10 ,  G01N33/48 ,  F04C28/02

Abstract: An embodiment of a system with a minute measure of pulsatility in a flow of a fluid is described that comprises a first pump configured to flow the fluid to a junction at a first flow rate that comprises a measure of pulsatility; and a second pump configured to flow a portion of the fluid from the junction at a second flow rate that is less than the first flow rate to produce a flow of the fluid at a third flow rate from the junction with a minute measure of pulsatility.

公开(公告)号：US10001434B2

公开(公告)日：2018-06-19

申请号：US14612820

申请日：2015-02-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Gregory Kaduchak ,  Jace Akerlund ,  Jason Malkin ,  Michael Ward

IPC: G01R35/00 ,  G01N15/10 ,  G01N15/14 ,  G06F11/30

CPC classification number: G01N15/1012 ,  G01N15/1404 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N2015/1018 ,  G01N2015/1068 ,  G01N2015/1075 ,  G01N2015/1438

Abstract: The present set of embodiments relates to systems and methods for diagnosing a fluidics system and determining data processing settings for a flow cytometer. Systems and methods for diagnosing a fluidics system require accurate measurement and interpretation of fluctuations within the fluid delivery system. Systems and methods for determining data processing settings require an accurate measurement of peak times among various channels and being able to adjust time delay settings wherein peak time is the measurement of time elapsed from the beginning of the data collection time window to the highest peak in the window.

公开(公告)号：US20150053561A1

公开(公告)日：2015-02-26

申请号：US14464763

申请日：2014-08-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael Ward ,  Gregory Kaduchak

IPC: G01N27/447 ,  G01N15/12 ,  G01N15/14

CPC classification number: G01N15/1404 ,  A61M1/3678 ,  G01N15/12 ,  G01N15/147 ,  G01N21/1702 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/447 ,  G01N29/222 ,  G01N33/56966 ,  G01N2015/1409 ,  G01N2015/1415 ,  G01N2015/142 ,  G01N2291/02416 ,  G01N2291/02809 ,  G01N2291/02836 ,  Y10T436/101666 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: The present invention comprises methods and systems that use acoustic radiation pressure.

公开(公告)号：US11020745B2

公开(公告)日：2021-06-01

申请号：US16224072

申请日：2018-12-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael Ward ,  Jason Malkin ,  Ken Lefton ,  Saul Selberg

IPC: B01L3/00 ,  G01N15/14 ,  G01N15/10

Abstract: The present disclosure provides devices, systems and methods for concentrating particles after application of a field and flipping the direction of the particles. The field applied to the particles can be an acoustic field. The particles can be flipped from a first flow stream at a higher speed into a second flow stream at a lower speed to aid in concentrating the particles, including concentration within an analysis region.

公开(公告)号：US10890596B2

公开(公告)日：2021-01-12

申请号：US16106682

申请日：2018-08-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Glen Davis ,  John Jackson ,  Gregory Kaduchak ,  Wesley Smith ,  Michael Ward

IPC: G01N35/10 ,  G01N35/00 ,  G01N15/14

Abstract: A sampling system is provided. The sampling system includes a housing. Mounted to the housing is a Hall effect sensor. A probe configured to contact a sample is inserted into the housing. The probe includes an elongated portion and a restorative spring inserted onto the elongated portion of the probe. The restorative spring provides sufficient restorative force to return the probe to a relaxed position. The Hall effect sensor is configured to sense a field strength generated by the proximity of the restorative spring of the probe in the extended position.