公开(公告)号：US20070161795A1

公开(公告)日：2007-07-12

申请号：US10589769

申请日：2005-02-17

申请人： Ladislav Cvak ,  Jiri Holan ,  Lubomir Roder

发明人： Ladislav Cvak ,  Jiri Holan ,  Lubomir Roder

IPC分类号： C07D457/00

CPC分类号： C07D519/02 ,  C07D471/06

摘要： Ergot alkaloids are isolated from ergot in high yields and purity by a process including extracting Claviceps purpurea, i.e., ergot, with a toluene/ethanol solvent mixture to obtain a primary extract. The primary extract can be further subjected to two steps of liquid-liquid extraction to purify the alkaloids resulting in a purified toluene extract. The toluene extract can be further partially evaporated and a crystalline product obtained by crystallization from the toluene or a mixture of toluene and an aliphatic hydrocarbon.

摘要翻译： 通过包括用甲苯/乙醇溶剂混合物萃取克拉维酵母紫草，麦角来获得初级提取物的方法，以高产率和纯度分离麦角生物碱。 主要提取物可以进一步进行液 - 液萃取两步，以净化生物碱，得到纯化的甲苯提取物。 甲苯提取物可以进一步部分蒸发，并通过从甲苯或甲苯和脂族烃的混合物中结晶获得的结晶产物。