公开(公告)号：US20150078997A1

公开(公告)日：2015-03-19

申请号：US14492896

申请日：2014-09-22

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Richard R. Cesati ,  Thomas D. Harris ,  Simon P. Robinson ,  Richard J. Looby ,  Edward H. Cheesman ,  Padmaja Yalamanchili ,  David S. Casebier

IPC: A61K51/04

CPC classification number: A61K51/0497 ,  A61K49/085 ,  A61K49/10 ,  A61K51/0406 ,  C07C259/06 ,  C07C271/22 ,  C07D257/02

Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

公开(公告)号：US20170258947A1

公开(公告)日：2017-09-14

申请号：US15433387

申请日：2017-02-15

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Richard R. Cesati ,  Edward H. Cheesman ,  Joel Lazewatsky ,  Heike S. Radeke ,  Enrico Mongeau ,  Dianne D. Zdankiewicz ,  Marybeth Devine

IPC: A61K51/04 ,  C07D407/12 ,  C07D237/16

CPC classification number: A61K51/0459 ,  C07D237/16 ,  C07D407/12

Abstract: The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

公开(公告)号：US20130315822A1

公开(公告)日：2013-11-28

申请号：US13723333

申请日：2012-12-21

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Richard R. Cesati ,  Thomas D. Harris ,  Simon P. Robinson ,  Richard J. Looby ,  Edward H. Cheesman ,  Padmaja Yalamanchili ,  David S. Casebier

IPC: A61K49/10 ,  A61K51/04

CPC classification number: C07D257/02 ,  A61K49/103 ,  A61K49/106 ,  A61K51/04 ,  C07C53/18 ,  C07C259/06 ,  C07C259/14 ,  C07C271/22 ,  C07C2601/14 ,  C07D209/20 ,  C07D213/56 ,  C07D403/12

Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

公开(公告)号：US09682927B2

公开(公告)日：2017-06-20

申请号：US15170848

申请日：2016-06-01

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Ajay Purohit ,  Pedro Benites ,  Edward H. Cheesman ,  Richard R. Cesati ,  Richard J. Looby ,  Heike S. Radeke

IPC: A61K51/00 ,  A61M36/14 ,  C07C303/30 ,  A61K51/04 ,  C07B59/00 ,  C07C53/06 ,  C07C217/58 ,  C07C255/54 ,  C07C277/08 ,  C07C279/10 ,  C07C279/24 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C53/10 ,  C07C53/18 ,  C07C63/08 ,  C07C213/02 ,  C07C303/28 ,  C07C309/04 ,  C07C309/30 ,  C07C277/00

CPC classification number: C07C303/30 ,  A61K51/00 ,  A61K51/04 ,  A61K51/0406 ,  C07B59/001 ,  C07B2200/05 ,  C07C53/06 ,  C07C53/10 ,  C07C53/18 ,  C07C63/08 ,  C07C213/02 ,  C07C217/58 ,  C07C255/54 ,  C07C277/00 ,  C07C277/08 ,  C07C279/10 ,  C07C279/24 ,  C07C303/28 ,  C07C309/04 ,  C07C309/30 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C279/08

Abstract: The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

公开(公告)号：US09393329B2

公开(公告)日：2016-07-19

申请号：US14492896

申请日：2014-09-22

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Richard R. Cesati ,  Thomas D. Harris ,  Simon P. Robinson ,  Richard J. Looby ,  Edward H. Cheesman ,  Padmaja Yalamanchili ,  David S. Casebier

IPC: A61K49/10 ,  A61K51/04 ,  A61K49/08 ,  C07C259/06 ,  C07C271/22 ,  C07D257/02

CPC classification number: A61K51/0497 ,  A61K49/085 ,  A61K49/10 ,  A61K51/0406 ,  C07C259/06 ,  C07C271/22 ,  C07D257/02

Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

公开(公告)号：US20160185737A1

公开(公告)日：2016-06-30

申请号：US14977249

申请日：2015-12-21

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Richard R. Cesati ,  Thomas D. Harris ,  Simon P. Robinson ,  Richard J. Looby ,  Edward H. Cheesman ,  Padmaja Yalamanchili ,  David S. Casebier

IPC: C07D257/02 ,  A61K49/10 ,  C07D209/20 ,  C07D213/56 ,  C07C259/06 ,  C07C53/18

CPC classification number: C07D257/02 ,  A61K49/103 ,  A61K49/106 ,  A61K51/04 ,  C07C53/18 ,  C07C259/06 ,  C07C259/14 ,  C07C271/22 ,  C07C2601/14 ,  C07D209/20 ,  C07D213/56 ,  C07D403/12

Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

公开(公告)号：US10022462B2

公开(公告)日：2018-07-17

申请号：US15433387

申请日：2017-02-15

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Richard R. Cesati ,  Edward H. Cheesman ,  Joel Lazewatsky ,  Heike S. Radeke ,  Enrico Mongeau ,  Dianne D. Zdankiewicz ,  Marybeth Devine

IPC: A61K51/04 ,  C07D237/16 ,  C07D407/12

Abstract: The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

公开(公告)号：US09266846B2

公开(公告)日：2016-02-23

申请号：US14474566

申请日：2014-09-02

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Richard R. Cesati ,  Thomas D. Harris ,  Simon P. Robinson ,  Richard J. Looby ,  Edward H. Cheesman ,  Padmaja Yalamanchili ,  David S. Casebier

IPC: C07D257/02 ,  C07D209/20 ,  A61K49/10 ,  A61K51/04 ,  C07C259/14 ,  C07C271/22 ,  C07D213/56 ,  C07D403/12 ,  C07C53/18 ,  C07C259/06

CPC classification number: C07D257/02 ,  A61K49/103 ,  A61K49/106 ,  A61K51/04 ,  C07C53/18 ,  C07C259/06 ,  C07C259/14 ,  C07C271/22 ,  C07C2601/14 ,  C07D209/20 ,  C07D213/56 ,  C07D403/12

Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

公开(公告)号：US08852553B2

公开(公告)日：2014-10-07

申请号：US13723333

申请日：2012-12-21

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Richard R. Cesati ,  Thomas D. Harris ,  Simon P. Robinson ,  Richard J. Looby ,  Edward H. Cheesman ,  Padmaja Yalamanchili ,  David S. Casebier

IPC: A61K49/00 ,  A61K49/04 ,  A61K51/04 ,  C07C271/22 ,  C07D403/12 ,  C07C259/14 ,  C07D257/02 ,  C07D213/56 ,  C07D209/20 ,  A61K49/10

CPC classification number: C07D257/02 ,  A61K49/103 ,  A61K49/106 ,  A61K51/04 ,  C07C53/18 ,  C07C259/06 ,  C07C259/14 ,  C07C271/22 ,  C07C2601/14 ,  C07D209/20 ,  C07D213/56 ,  C07D403/12

Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

Abstract translation: 本公开涉及化合物，诊断剂和相关方法。 在某些情况下，提供了治疗患者的方法。 更具体地，本公开提供了用于检测和/或成像和/或监测富含弹性蛋白的组织的化合物，诊断剂和试剂盒。 此外，本公开提供了检测和/或成像和/或监测冠状动脉斑块，颈动脉斑块，髂骨/股骨斑块，主动脉斑块，肾动脉斑块，任何动脉血管的斑块，动脉瘤，血管炎，其他疾病的存在的方法 的动脉壁，和/或韧带，子宫，肺或皮肤的损伤或结构变化，如总血管壁面积，内腔大小和外动脉周长的变化所示。

公开(公告)号：US09732047B2

公开(公告)日：2017-08-15

申请号：US14977249

申请日：2015-12-21

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Richard R. Cesati ,  Thomas D. Harris ,  Richard J. Looby ,  Edward H. Cheesman ,  David S. Casebier

IPC: A61K49/10 ,  C07D257/02 ,  C07C259/14 ,  C07C271/22 ,  C07D209/20 ,  C07D213/56 ,  C07D403/12 ,  A61K51/04 ,  C07C53/18 ,  C07C259/06

CPC classification number: C07D257/02 ,  A61K49/103 ,  A61K49/106 ,  A61K51/04 ,  C07C53/18 ,  C07C259/06 ,  C07C259/14 ,  C07C271/22 ,  C07C2601/14 ,  C07D209/20 ,  C07D213/56 ,  C07D403/12

Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.