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    Lung Cancer Biomarkers and Uses Thereof
    2.
    发明申请
    Lung Cancer Biomarkers and Uses Thereof 审中-公开
    肺癌生物标志物及其用途

    公开(公告)号：US20100070191A1

    公开(公告)日：2010-03-18

    申请号：US12556480

    申请日：2009-09-09

    申请人： Larry Gold ,  Marty Stanton ,  Edward N. Brody ,  Rachel M. Ostroff ,  Dominic Zichi ,  Alex A.E. Stewart

    发明人： Larry Gold ,  Marty Stanton ,  Edward N. Brody ,  Rachel M. Ostroff ,  Dominic Zichi ,  Alex A.E. Stewart

    IPC分类号： G01N33/574 ,  C12Q1/02 ,  G06F19/00

    CPC分类号： G01N33/57423

    摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本申请包括用于肺癌的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 在一个方面，该应用提供可以单独使用或以各种组合使用以诊断肺癌或允许肺结节的鉴别诊断为良性或恶性的生物标志物。 在另一方面，提供了用于诊断个体中的肺癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表1中提供的生物标志物组的至少一种生物标志物的生物标记值 ，第2栏，其中基于所述至少一种生物标记值，将个体分类为具有肺癌或确定患有肺癌的个体的可能性。

    Lung cancer biomarkers and uses thereof
    3.
    发明授权
    Lung cancer biomarkers and uses thereof 有权

    公开(公告)号：US10359425B2

    公开(公告)日：2019-07-23

    申请号：US12556480

    申请日：2009-09-09

    申请人： Larry Gold ,  Marty Stanton ,  Edward N. Brody ,  Rachel M. Ostroff ,  Dominic Zichi ,  Alex A. E. Stewart

    发明人： Larry Gold ,  Marty Stanton ,  Edward N. Brody ,  Rachel M. Ostroff ,  Dominic Zichi ,  Alex A. E. Stewart

    IPC分类号： G01N33/574

    摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.

    Multiplexed analyses of test samples
    4.
    发明授权
    Multiplexed analyses of test samples 有权
    测试样品的多重分析

    公开(公告)号：US07855054B2

    公开(公告)日：2010-12-21

    申请号：US12175446

    申请日：2008-07-17

    申请人： Daniel J. Schneider ,  Dan Nieuwlandt ,  Bruce Eaton ,  Marty Stanton ,  Shashi Gupta ,  Stephan Kraemer ,  Dominic Zichi ,  Larry Gold

    发明人： Daniel J. Schneider ,  Dan Nieuwlandt ,  Bruce Eaton ,  Marty Stanton ,  Shashi Gupta ,  Stephan Kraemer ,  Dominic Zichi ,  Larry Gold

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

    CPC分类号： G01N33/5308 ,  C12Q1/6832 ,  C12Q1/6834 ,  C12Q2537/101 ,  C12Q2525/205 ,  C12Q2523/313 ,  C12Q2525/161

    摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

    摘要翻译： 本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。 所描述的方法，装置，试剂盒和试剂通过检测和定量核酸（即，适体）促进了测试样品中非核酸靶标（例如，蛋白质靶标）的检测和定量。 所描述的方法为非核酸靶产生了核酸替代物，从而允许将广泛种类的核酸技术（包括扩增）应用于更广泛的期望目标，特别是蛋白质靶标。 本公开进一步描述了适于在各种分析检测应用中促进适配体使用的适体构建体。

    Ovarian Cancer Biomarkers and Uses Thereof
    6.
    发明申请
    Ovarian Cancer Biomarkers and Uses Thereof 审中-公开
    卵巢癌生物标志物及其用途

    公开(公告)号：US20100221752A2

    公开(公告)日：2010-09-02

    申请号：US12574341

    申请日：2009-10-06

    申请人： Larry Gold ,  Marty Stanton ,  Edward Brody ,  Rachel Ostroff ,  Dominic Zichi ,  Alex Stewart

    发明人： Larry Gold ,  Marty Stanton ,  Edward Brody ,  Rachel Ostroff ,  Dominic Zichi ,  Alex Stewart

    IPC分类号： G01N33/567 ,  G01N33/53 ,  G06F19/00 ,  G06F17/18

    CPC分类号： G01N33/57449 ,  G06F19/24 ,  Y10T436/143333

    摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of ovarian cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose ovarian cancer or permit the differential diagnosis of a pelvic mass as benign or malignant. In another aspect, methods are provided for diagnosing ovarian cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having ovarian cancer, or the likelihood of the individual having ovarian cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本申请包括用于卵巢癌的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 一方面，本申请提供可以单独使用或以各种组合使用以诊断卵巢癌或允许骨盆块的鉴别诊断为良性或恶性的生物标志物。 在另一方面，提供了用于诊断个体中的卵巢癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表1中提供的生物标志物组的至少一种生物标志物的生物标记值 ，其中基于所述至少一种生物标志物值将所述个体分类为具有卵巢癌或确定具有卵巢癌的个体的可能性。

    Multiplexed Analyses of Test Samples
    7.
    发明申请
    Multiplexed Analyses of Test Samples 有权
    测试样本的多路复用分析

    公开(公告)号：US20090042206A1

    公开(公告)日：2009-02-12

    申请号：US12175446

    申请日：2008-07-17

    申请人： Daniel J. Schneider ,  Dan Nieuwlandt ,  Bruce Eaton ,  Marty Stanton ,  Shashi Gupta ,  Stephan Kraemer ,  Dominic Zichi ,  Larry Gold

    发明人： Daniel J. Schneider ,  Dan Nieuwlandt ,  Bruce Eaton ,  Marty Stanton ,  Shashi Gupta ,  Stephan Kraemer ,  Dominic Zichi ,  Larry Gold

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/5308 ,  C12Q1/6832 ,  C12Q1/6834 ,  C12Q2537/101 ,  C12Q2525/205 ,  C12Q2523/313 ,  C12Q2525/161

    摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

    摘要翻译： 本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。 所描述的方法，装置，试剂盒和试剂通过检测和定量核酸（即，适体）促进了测试样品中非核酸靶标（例如，蛋白质靶标）的检测和定量。 所描述的方法为非核酸靶产生了核酸替代物，从而允许将广泛种类的核酸技术（包括扩增）应用于更广泛的期望目标，特别是蛋白质靶标。 本公开进一步描述了适于在各种分析检测应用中促进适配体使用的适体构建体。