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1.发明授权Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes 有权递送AS-寡核苷酸微球以诱导树突细胞耐受治疗自身免疫性1型糖尿病公开(公告)号：US07884085B2
公开(公告)日：2011-02-08
申请号：US11127360
申请日：2005-05-12
申请人： Larry R. Brown , Vered Bisker-Leib , Terrence L. Scott , Debra Lafreniere , Jennifer Machen , Nick Giannoukakls
发明人： Larry R. Brown , Vered Bisker-Leib , Terrence L. Scott , Debra Lafreniere , Jennifer Machen , Nick Giannoukakls
CPC分类号： C12N15/1138 , A61K9/0019 , A61K9/1635 , A61K9/1641 , A61K9/1658 , A61K9/19 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2320/32
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。 微球合并反义（AS）寡核苷酸。 一种方法包括使用反义方法在体内和原位抑制NOD小鼠中的自身免疫性糖尿病状况。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
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2.发明申请DELIVERY OF AS-OLIGONUCLEOTIDE MICROSPHERES TO INDUCE DENDRITIC CELL TOLERANCE FOR THE TREATMENT OF AUTOIMMUNE TYPE 1 DIABETES 有权递送AS-OLIGONUCLEOTIDE MICROSPHERES以诱导用于治疗自身免疫型1型糖尿病的DENDRITIC CELL ROLERANCE公开(公告)号：US20100260855A1
公开(公告)日：2010-10-14
申请号：US12822774
申请日：2010-06-24
申请人： Larry R. Brown , Vered Bisker-Leib , Terrence L. Scott , Debra Lafreniere , Jennifer Machen , Nick Giannoukakis
发明人： Larry R. Brown , Vered Bisker-Leib , Terrence L. Scott , Debra Lafreniere , Jennifer Machen , Nick Giannoukakis
IPC分类号： A61K31/711 , A61K9/14 , A61K31/7088 , A61P3/10 , A61P37/06
CPC分类号： C12N15/1138 , A61K9/0019 , A61K9/1635 , A61K9/1641 , A61K9/1658 , A61K9/19 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2320/32
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。 微球合并反义（AS）寡核苷酸。 一种方法包括使用反义方法在体内和原位抑制NOD小鼠中的自身免疫性糖尿病状况。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
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3.发明授权Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes 有权递送AS-寡核苷酸微球以诱导树突细胞耐受治疗自身免疫性1型糖尿病公开(公告)号：US09115357B2
公开(公告)日：2015-08-25
申请号：US12822774
申请日：2010-06-24
申请人： Larry R. Brown , Vered Bisker-Leib , Terrence L. Scott , Debra Lafreniere , Jennifer Machen , Nick Giannoukakis
发明人： Larry R. Brown , Vered Bisker-Leib , Terrence L. Scott , Debra Lafreniere , Jennifer Machen , Nick Giannoukakis
IPC分类号： A61K31/711 , A61K9/14 , A61K31/7088 , A61P3/10 , A61P37/06 , C12N15/113 , A61K9/00 , A61K9/16 , A61K9/19 , C12N15/11
CPC分类号： C12N15/1138 , A61K9/0019 , A61K9/1635 , A61K9/1641 , A61K9/1658 , A61K9/19 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2320/32
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。 微球合并反义（AS）寡核苷酸。 一种方法包括使用反义方法在体内和原位抑制NOD小鼠中的自身免疫性糖尿病状况。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
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公开(公告)号：US07815941B2
公开(公告)日：2010-10-19
申请号：US11127362
申请日：2005-05-12
CPC分类号： A61K9/1629 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2320/32 , Y10T428/2982
摘要： Nucleic acids are prepared by dissolving compounds containg them in a suitable solvent or solvent system and forming microspheres from the resulting solution. The microspheres are administered to an individual as protection from conditions where delivery of nucleic acids is useful, such as in treatment of autoimmune disease.
摘要翻译： 通过将包含它们的化合物溶解在合适的溶剂或溶剂体系中并从所得溶液中形成微球体来制备核酸。 将微球施用于个体，作为防止核酸递送有用的条件的保护，例如治疗自身免疫性疾病。
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5.发明申请Delivery of as-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes 有权递送寡核苷酸微球以诱导树突状细胞耐受治疗自身免疫性1型糖尿病公开(公告)号：US20060024240A1
公开(公告)日：2006-02-02
申请号：US11127360
申请日：2005-05-12
申请人： Larry Brown , Vered Bisker-Leib , Terrence Scott , Debra Lafreniere , Jennifer Mochen , Nick Giannoukakls
发明人： Larry Brown , Vered Bisker-Leib , Terrence Scott , Debra Lafreniere , Jennifer Mochen , Nick Giannoukakls
CPC分类号： C12N15/1138 , A61K9/0019 , A61K9/1635 , A61K9/1641 , A61K9/1658 , A61K9/19 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2320/32
摘要： AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
摘要翻译： AS寡核苷酸以微球形式递送，以诱导树突细胞耐受，特别是在非肥胖 - 糖尿病（NOD）小鼠模型中。 微球合并反义（AS）寡核苷酸。 一种方法包括使用反义方法在体内和原位抑制NOD小鼠中的自身免疫性糖尿病状况。 靶向寡核苷酸以结合初级转录物CD40，CD80，CD86及其组合。
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公开(公告)号：US09339465B2
公开(公告)日：2016-05-17
申请号：US12878783
申请日：2010-09-09
IPC分类号： A61K9/14 , A61K31/7088 , A61P37/00 , B32B5/16 , A61K9/16 , C12N15/11 , C12N15/113
CPC分类号： A61K9/1629 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2320/32 , Y10T428/2982
摘要： Nucleic acids are prepared by dissolving compounds containing them in a suitable solvent or solvent system and forming microspheres from the resulting solution. The microspheres are administered to an individual as protection from conditions where delivery of nucleic acids is useful, such as in treatment of autoimmune disease.
摘要翻译： 通过将含有它们的化合物溶解在合适的溶剂或溶剂体系中并从所得溶液中形成微球体来制备核酸。 将微球施用于个体，作为防止核酸递送有用的条件的保护，例如治疗自身免疫性疾病。
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公开(公告)号：US20060018971A1
公开(公告)日：2006-01-26
申请号：US11127362
申请日：2005-05-12
CPC分类号： A61K9/1629 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2320/32 , Y10T428/2982
摘要： Nucleic acids are prepared by dissolving compounds containg them in a suitable solvent or solvent system and forming microshperes from the resulting solution. The microspheres are administered to an individual as protection from conditions where delivery of nuceic acids is useful, such as in treatment of autoimmune disease.
摘要翻译： 通过将含有它们的化合物溶解在合适的溶剂或溶剂体系中并从所得溶液中形成微胶粒来制备核酸。 将微球体施用于个体，作为防止尿酸递送有用的条件，例如治疗自身免疫性疾病。
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8.发明申请Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof 审中-公开低分子量有机分子的小球形颗粒及其制备方法和用途公开(公告)号：US20050048127A1
公开(公告)日：2005-03-03
申请号：US10896326
申请日：2004-07-21
申请人： Larry Brown , Debra Lafreniere , John McGeehan
发明人： Larry Brown , Debra Lafreniere , John McGeehan
IPC分类号： A61K20060101 , A61K9/00 , A61K9/14
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0075
摘要： The invention provides homogeneous small spherical particles of low molecular weight organic molecules, said small spherical particles having a uniform shape, a narrow size distribution and average diameter of 0.01-200 μm. The invention further provides methods of preparation and methods of use of the small spherical particles. These small spherical particles are suitable for applications that require delivery of micron-size or nanosized particles with uniform size and good aerodynamic or flow characteristics. Pulmonary, intravenous, and other means of administration are among the delivery routes that may benefit from these small spherical particles.
摘要翻译： 本发明提供均匀的低分子量有机分子的小球形颗粒，所述小球形颗粒具有均匀的形状，窄尺寸分布和平均直径为0.01-200μm。 本发明还提供了制备方法和使用小球形颗粒的方法。 这些小球形颗粒适用于需要输送具有均匀尺寸和良好空气动力学或流动特性的微米级或纳米尺寸颗粒的应用。 可以从这些小球形颗粒中受益的输送途径之中，肺，静脉内和其它施用方式。
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