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1.发明授权Orthotopic and genetically tractable non-human animal model for liver cancer and the uses thereof 有权肝癌的原位和遗传易感性非人动物模型及其用途公开(公告)号：US08137907B2
公开(公告)日：2012-03-20
申请号：US12072115
申请日：2008-02-21
申请人： Lars Zender , Scott W. Lowe , Mona S. Spector
发明人： Lars Zender , Scott W. Lowe , Mona S. Spector
CPC分类号： A01K67/0271 , A01K2217/058 , A01K2267/0331 , C07K14/4747 , C12N15/8509 , C12N2510/04 , C12N2517/02 , C12N2799/027 , G01N33/5067 , G01N33/57438 , G01N2500/00 , G01N2800/52
摘要： This invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both and by transplanting the resulting hepatocytes into a recipient non-human animal.This invention also relates to the use of RNA interference (RNAi) technology in vivo to efficiently identify genes associated with liver cancer, in particular those encoding tumor suppressors, by knocking out candidate genes using RNAi and observing whether tumors would develop.
摘要翻译： 本发明提供了用于肝细胞癌的遗传易处理的非人动物模型。 该模型除其他外，有助于理解肝癌的分子机制，了解导致化学耐药性或预后不良的遗传改变，以及鉴定和评估针对肝细胞癌的新疗法。 本发明的肝癌模型通过改变肝细胞以增加癌基因表达，减少肿瘤抑制基因表达或两者并通过将所得肝细胞移植到受体非人动物中来制备。 本发明还涉及RNA干扰（RNAi）技术在体内有效地鉴定与肝癌相关的基因，特别是编码肿瘤抑制因子的基因，通过使用RNAi敲除候选基因并观察肿瘤是否会发展。
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公开(公告)号：US20110035814A1
公开(公告)日：2011-02-10
申请号：US12301980
申请日：2007-05-23
申请人： Lars Zender , Scott W. Lowe , Mona S. Spector , Wen Xue
发明人： Lars Zender , Scott W. Lowe , Mona S. Spector , Wen Xue
IPC分类号： C12Q1/68 , C12N5/071 , A01K67/027 , C12Q1/02
CPC分类号： C12Q1/6886 , A01K2217/05 , A01K2267/0331 , C07K14/4747 , C07K14/82 , C12N2510/04 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： This invention provides methods of diagnosis, drug screening, and treatment based on the discovery that cIAP1 and Yap are co-amplified oncogenes that cooperate to contribute to oncogenesis and tumor maintenance.
摘要翻译： 本发明提供了诊断，药物筛选和治疗的方法，基于以下发现，cIAP1和Yap是共同扩增癌基因，其协作以有助于肿瘤发生和肿瘤维持。
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3.发明申请Orthotopic and genetically tractable non-human animal model for liver cancer and the uses thereof 有权肝癌的原位和遗传易感性非人动物模型及其用途公开(公告)号：US20090029872A1
公开(公告)日：2009-01-29
申请号：US12072115
申请日：2008-02-21
申请人： Lars Zender , Scott W. Lowe , Mona S. Spector
发明人： Lars Zender , Scott W. Lowe , Mona S. Spector
CPC分类号： A01K67/0271 , A01K2217/058 , A01K2267/0331 , C07K14/4747 , C12N15/8509 , C12N2510/04 , C12N2517/02 , C12N2799/027 , G01N33/5067 , G01N33/57438 , G01N2500/00 , G01N2800/52
摘要： This invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both and by transplanting the resulting hepatocytes into a recipient non-human animal.This invention also relates to the use of RNA interference (RNAi) technology in vivo to efficiently identify genes associated with liver cancer, in particular those encoding tumor suppressors, by knocking out candidate genes using RNAi and observing whether tumors would develop.
摘要翻译： 本发明提供了用于肝细胞癌的遗传易处理的非人动物模型。 该模型除其他外，有助于理解肝癌的分子机制，了解导致化学耐药性或预后不良的遗传改变，以及鉴定和评估针对肝细胞癌的新疗法。 本发明的肝癌模型通过改变肝细胞以增加癌基因表达，减少肿瘤抑制基因表达或两者并通过将所得肝细胞移植到受体非人动物中来制备。 本发明还涉及RNA干扰（RNAi）技术在体内有效地鉴定与肝癌相关的基因，特别是编码肿瘤抑制因子的基因，通过使用RNAi敲除候选基因并观察肿瘤是否会发展。
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