公开(公告)号：US20100273660A1

公开(公告)日：2010-10-28

申请号：US12617624

申请日：2009-11-12

申请人： Lars Zender ,  Wen Xue ,  Scott Powers ,  Scott W. Lowe

发明人： Lars Zender ,  Wen Xue ,  Scott Powers ,  Scott W. Lowe

IPC分类号： C40B20/06 ,  C07K16/00 ,  C40B50/04 ,  C40B40/06 ,  C12N5/09 ,  C12Q1/68 ,  G01N33/574

CPC分类号： A01K67/0271 ,  A01K2217/058 ,  A01K2267/0331 ,  C07K14/4747 ,  C12N15/1079 ,  C12N15/8509 ,  C12N2510/04 ,  C12N2517/02 ,  C12N2799/027 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/178 ,  G01N33/5044 ,  G01N33/5067 ,  G01N33/5088 ,  G01N33/57415 ,  G01N33/57438 ,  G01N2500/00 ,  G01N2800/50 ,  G01N2800/52

摘要： In some aspects, the invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both and by transplanting the resulting hepatocytes into a recipient non-human animal.The present invention also provides methods for identifying and validating tumor suppressor genes by screening pools of shRNAs that target genomic regions deleted in human cancers, such as human hepatocellular carcinomas. The present invention also provides validated tumor suppressor genes, and methods of inhibiting cell proliferation and/or tumor growth, for example by expression of such tumor suppressor genes.

摘要翻译： 在一些方面，本发明提供了用于肝细胞癌的遗传易处的非人动物模型。 该模型除其他外，有助于理解肝癌的分子机制，了解导致化学耐药性或预后不良的遗传改变，以及鉴定和评估针对肝细胞癌的新疗法。 本发明的肝癌模型通过改变肝细胞以增加癌基因表达，减少肿瘤抑制基因表达或两者并通过将所得肝细胞移植到受体非人动物中来制备。 本发明还提供了通过筛选靶向人类癌症中缺失的基因组区域（例如人肝细胞癌）的shRNA的鉴定和验证肿瘤抑制基因的方法。 本发明还提供了经过验证的肿瘤抑制基因，以及例如通过表达这种肿瘤抑制基因来抑制细胞增殖和/或肿瘤生长的方法。

公开(公告)号：US07794941B2

公开(公告)日：2010-09-14

申请号：US11893086

申请日：2007-08-13

申请人： Scott Powers ,  Lars Zender ,  Rebecca A. Kohnz ,  Scott W. Lowe

发明人： Scott Powers ,  Lars Zender ,  Rebecca A. Kohnz ,  Scott W. Lowe

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12N5/0693 ,  A01K67/0271 ,  A01K2217/058 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/1825 ,  C12N2501/119 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136

摘要： The invention provides methods for diagnosing cancers in humans by detecting DNA amplifications in chromosomal region 8p22, which encompasses the FGF-20 gene and the EFHA2 gene. Also provided are cancer treatment methods using inhibitors of FGF-20 and EFHA2. The invention also provides methods for promoting successful regeneration of liver function. These methods can be used therapeutically to improve liver function following transplantation in both recipient and donor subjects.

摘要翻译： 本发明提供了通过检测包含FGF-20基因和EFHA2基因的染色体区域8p22中的DNA扩增来诊断人类癌症的方法。 还提供了使用FGF-20和EFHA2抑制剂的癌症治疗方法。 本发明还提供促进肝功能再生成功的方法。 这些方法可以治疗性地用于在接受者和供体受试者中移植后改善肝功能。

公开(公告)号：US20080188434A1

公开(公告)日：2008-08-07

申请号：US11893086

申请日：2007-08-13

申请人： Scott Powers ,  Lars Zender ,  Rebecca A. Kohnz ,  Scott W. Lowe

发明人： Scott Powers ,  Lars Zender ,  Rebecca A. Kohnz ,  Scott W. Lowe

IPC分类号： A61K31/70 ,  C12Q1/68 ,  C12N5/06 ,  A61P1/00 ,  A01K67/027

CPC分类号： C12N5/0693 ,  A01K67/0271 ,  A01K2217/058 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/1825 ,  C12N2501/119 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136

摘要： The invention provides methods for diagnosing cancers in humans by detecting DNA amplifications in chromosomal region 8p22, which encompasses the FGF-20 gene and the EFHA2 gene. Also provided are cancer treatment methods using inhibitors of FGF-20 and EFHA2. The invention also provides methods for promoting successful regeneration of liver function. These methods can be used therapeutically to improve liver function following transplantation in both recipient and donor subjects.

摘要翻译： 本发明提供了通过检测包含FGF-20基因和EFHA2基因的染色体区域8p22中的DNA扩增来诊断人类癌症的方法。 还提供了使用FGF-20和EFHA2抑制剂的癌症治疗方法。 本发明还提供促进肝功能再生成功的方法。 这些方法可以治疗性地用于在接受者和供体受试者中移植后改善肝功能。

公开(公告)号：US20150021831A1

公开(公告)日：2015-01-22

申请号：US13943836

申请日：2013-07-17

申请人： James Peplinski ,  Scott Powers

发明人： James Peplinski ,  Scott Powers

IPC分类号： B29C45/73 ,  B29C45/17 ,  B29C45/00 ,  B29C45/78

CPC分类号： B29C45/73 ,  B29C45/0025 ,  B29C45/1703 ,  B29C45/78 ,  B29L2031/30

摘要： A plastic injection molding system includes a mold having an interior surface and an exterior surface. The interior surface defines a mold cavity, which is configured in a shape of a part to be formed. A source of plastic, having a known heat deflection temperature, is injected into the mold cavity. At least one infrared heat source is disposed adjacent the mold. The at least one heat source is moveable between a first position disposed away from the interior surface of the mold and a second position where the at least one heat source is in communication with the mold cavity surface. A controller is in communication with the at least one heat source and is configured to heat the mold cavity surface to a predetermined temperature below the heat deflection temperature of the plastic resin. At least one temperature sensor is in communication with the interior surface of the mold and in communication with the controller to move the at least one heat source to the second position when the interior surface of the mold reaches the predetermined temperature.

摘要翻译： 塑料注塑系统包括具有内表面和外表面的模具。 内表面限定模具腔，其被构造成待形成的部件的形状。 将具有已知热变形温度的塑料源注入模腔中。 至少一个红外热源设置在模具附近。 所述至少一个热源可在离开所述模具的内表面设置的第一位置和所述至少一个热源与所述模腔表面连通的第二位置之间移动。 控制器与至少一个热源连通，并且被配置为将模腔表面加热到低于塑料树脂的热变形温度的预定温度。 当模具的内表面达到预定温度时，至少一个温度传感器与模具的内表面连通并与控制器连通，以将至少一个热源移动到第二位置。

公开(公告)号：US20140374959A1

公开(公告)日：2014-12-25

申请号：US13926047

申请日：2013-06-25

申请人： James Peplinski ,  Scott Powers

发明人： James Peplinski ,  Scott Powers

IPC分类号： B29C45/73 ,  B29C45/17

CPC分类号： B29C45/73 ,  B29C45/1701 ,  B29C45/1703 ,  B29C2945/7604 ,  B29C2945/7626 ,  B29C2945/76568 ,  B29C2945/76816 ,  B29C2945/76933

摘要： A plastic injection molding system includes a mold having an interior surface and an exterior surface. The interior surface defines a mold cavity, which is configured in a shape of a part to be formed. A source of plastic, having a known heat distortion temperature, is injected into the mold cavity. At least one infrared heat source is disposed adjacent the mold. The at least one heat source is moveable between a first position disposed away from the interior surface of the mold and a second position where the at least one heat source is in communication with the mold cavity surface. A controller is in communication with the at least one heat source and is configured to heat the mold cavity surface to a predetermined temperature below the heat distortion temperature of the plastic resin. At least one temperature sensor in is communication with the interior surface of the mold and in communication with the controller to move the at least one heat source to the second position when the interior surface of the mold reaches the predetermined temperature.

摘要翻译： 塑料注塑系统包括具有内表面和外表面的模具。 内表面限定模具腔，其被构造成待形成的部件的形状。 具有已知的热变形温度的塑料源被注入到模腔中。 至少一个红外热源设置在模具附近。 所述至少一个热源可在远离模具内表面设置的第一位置和至少一个热源与模腔表面连通的第二位置之间移动。 控制器与至少一个热源连通，并且被配置为将模腔表面加热到低于塑料树脂的热变形温度的预定温度。 当模具的内表面达到预定温度时，至少一个温度传感器与模具的内表面连通并与控制器连通，以将至少一个热源移动到第二位置。

公开(公告)号：US07909295B2

公开(公告)日：2011-03-22

申请号：US12221394

申请日：2008-08-01

申请人： Scott Powers ,  Joseph Szacon

发明人： Scott Powers ,  Joseph Szacon

IPC分类号： F16L3/00

CPC分类号： F16M11/04 ,  F16M13/02 ,  G06F1/16 ,  G06F1/1601 ,  G06F2200/1612 ,  G06F2200/1631 ,  Y10S248/917

摘要： A mounting for an all-in-one personal computer (10) that has a stand (12) for supporting the computer on a table or desk to enable the computer to be mounted on a wall or at the end of an articulated arm. A bracket (16) has a first wall (16A) that is disposed to confront a face of the stand surrounding the through-hole in the stand and that contains a through-hole (24) that registers with a through-hole (26) in the stand and a second wall (16B) that joins with the first wall and that contains a VESA compliant hole pattern that provides for attachment to a VESA compliant member. A hollow bolt (20) and a nut (22) coact with the registered through-holes to hold the first wall of the bracket fast on the stand.

摘要翻译： 一种用于一体式个人计算机（10）的安装件，其具有用于将计算机支撑在桌子或桌子上的支架（12），以使计算机能够安装在壁挂或铰接臂的末端。 支架（16）具有第一壁（16A），该第一壁（16A）设置成与支架周围的通孔的面相对，并且包含与通孔（26）对准的通孔（24） 以及与第一壁连接并且包含符合VESA的孔图案的第二壁（16B），其提供附接到符合VESA标准的构件。 中空螺栓（20）和螺母（22）与登记的通孔共同作用以将支架的第一壁快速地保持在支架上。

公开(公告)号：US20070027422A1

公开(公告)日：2007-02-01

申请号：US11494325

申请日：2006-07-25

申请人： Carlos Becerra ,  William Chandler ,  Scott Powers ,  Abebaw Zeleke

发明人： Carlos Becerra ,  William Chandler ,  Scott Powers ,  Abebaw Zeleke

IPC分类号： A61F5/00

CPC分类号： A61F5/04 ,  A61H1/0218 ,  A61H1/0222 ,  A61H1/0296 ,  A61H2201/018 ,  A61H2201/1607 ,  A61H2203/0493

摘要： A cervical traction device includes a base, a cervical force application member, and a motor operably attached to the cervical force application member. The motor preferably drives the cervical application member through a friction drive system in order to provide a force to a person's cervical vertebrae. The friction drive system provides overload protection to prevent application of excessive traction forces to the patient.

摘要翻译： 颈椎牵引装置包括基部，颈部力施加构件和可操作地附接到子宫颈力施加构件的马达。 电动机优选地通过摩擦驱动系统驱动子宫颈施用构件，以向人的颈椎提供力。 摩擦驱动系统提供过载保护，以防止对患者施加过大的牵引力。

公开(公告)号：US20090039221A1

公开(公告)日：2009-02-12

申请号：US12221394

申请日：2008-08-01

申请人： Scott Powers ,  Joseph Szacon

发明人： Scott Powers ,  Joseph Szacon

IPC分类号： A47F5/00 ,  A47B96/06

CPC分类号： F16M11/04 ,  F16M13/02 ,  G06F1/16 ,  G06F1/1601 ,  G06F2200/1612 ,  G06F2200/1631 ,  Y10S248/917

摘要： A mounting for an all-in-one personal computer (10) that has a stand (12) for supporting the computer on a table or desk to enable the computer to be mounted on a wall or at the end of an articulated arm. A bracket (16) has a first wall (16A) that is disposed to confront a face of the stand surrounding the through-hole in the stand and that contains a through-hole (24) that registers with a through-hole (26) in the stand and a second wall (16B) that joins with the first wall and that contains a VESA compliant hole pattern that provides for attachment to a VESA compliant member. A hollow bolt (20) and a nut (22) coact with the registered through-holes to hold the first wall of the bracket fast on the stand.

摘要翻译： 一种用于一体式个人计算机（10）的安装件，其具有用于将计算机支撑在桌子或桌子上的支架（12），以使计算机能够安装在壁挂或铰接臂的末端。 支架（16）具有第一壁（16A），该第一壁（16A）设置成与支架周围的通孔的面相对，并且包含与通孔（26）对准的通孔（24） 以及与第一壁连接并且包含符合VESA的孔图案的第二壁（16B），其提供附接到符合VESA标准的构件。 中空螺栓（20）和螺母（22）与登记的通孔共同作用以将支架的第一壁快速地保持在支架上。

公开(公告)号：US20080234470A1

公开(公告)日：2008-09-25

申请号：US11968795

申请日：2008-01-03

申请人： David Mu ,  Scott Powers

发明人： David Mu ,  Scott Powers

IPC分类号： C07K16/18

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention provides nucleic acid and protein sequences for a novel potassium channel protein, KCNB. The herein-disclosed sequences can be used for any of a number of purposes, including for the specific detection of KCNB, for the identification of molecules that associate with and/or modulate the activity of KCNB, to diagnose any of a number of conditions associated with KCNB or KCNB activity, or to modulate the number or activity of KCNB molecules in a mammal.

摘要翻译： 本发明提供新的钾通道蛋白KCNB的核酸和蛋白质序列。 本文所公开的序列可以用于许多目的中的任何一个，包括用于特异性检测KCNB，用于鉴定与KCNB的活性相关联和/或调节KCNB的活性的分子，以诊断相关的多种病症中的任何一种 KCNB或KCNB活性，或调节哺乳动物中KCNB分子的数量或活性。

公开(公告)号：US07084259B2

公开(公告)日：2006-08-01

申请号：US10633894

申请日：2003-08-04

申请人： Scott Powers ,  Jianxin Yang ,  Gene Cutler

发明人： Scott Powers ,  Jianxin Yang ,  Gene Cutler

IPC分类号： C07K16/28

CPC分类号： C07K14/723

摘要： The invention provides isolated nucleic acid and amino acid sequences of four novel G-protein coupled receptors that are amplified in breast cancer cells, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of G-protein coupled receptors.

摘要翻译： 本发明提供了在乳腺癌细胞中扩增的四种新型G蛋白偶联受体的分离的核酸和氨基酸序列，这种受体的抗体，检测这种核酸和受体的方法，以及筛选G蛋白调节剂的方法 偶联受体。