公开(公告)号：US20090099165A1

公开(公告)日：2009-04-16

申请号：US11735344

申请日：2007-04-13

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/5377 ,  C07D487/04 ,  A61K31/519

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

公开(公告)号：US20110212929A1

公开(公告)日：2011-09-01

申请号：US13051790

申请日：2011-03-18

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/635 ,  C07D487/04 ,  A61K31/496 ,  C07D471/14 ,  A61K31/519 ,  C07D413/14 ,  A61K31/5377 ,  A61P35/00

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20090143399A1

公开(公告)日：2009-06-04

申请号：US11841574

申请日：2007-08-20

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/496 ,  C07D487/04 ,  C07D495/14 ,  C07D491/048 ,  A61P35/04

CPC分类号： C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20080207632A1

公开(公告)日：2008-08-28

申请号：US11932617

申请日：2007-10-31

申请人： David J. Bearss ,  Cory L. Grand ,  Xiao-Hui Liu ,  Hariprasad Vankayalapati

发明人： David J. Bearss ,  Cory L. Grand ,  Xiao-Hui Liu ,  Hariprasad Vankayalapati

IPC分类号： A61K31/496 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D403/04

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer, such as Aurora kinase-expressing cancers and Axl kinase-expressing cancers. Compounds of the invention have the following structure: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Z, L2 and w are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了蛋白激酶抑制剂可用于治疗蛋白激酶介导的疾病和病症，例如癌症，例如表达极光激酶的癌症和表达Ax1激酶的癌症。 本发明的化合物具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中R 1，R 2，R 3， X，Z，L 2和W如本文所定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20090029982A1

公开(公告)日：2009-01-29

申请号：US11912809

申请日：2006-04-28

申请人： David J. Bearss ,  Hariprasad Vankayalapati ,  Cory L. Grand

发明人： David J. Bearss ,  Hariprasad Vankayalapati ,  Cory L. Grand

IPC分类号： A61K31/519 ,  A61P35/00 ,  A61K31/5377 ,  C07D487/04

CPC分类号： C07D471/04

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the structure (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Z, L2 and w are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明的化合物具有包括其立体异构体，前药和药学上可接受的盐的结构（I），其中R 1，R 2，R 3，X，Z，L 2和W如本文所定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。