公开(公告)号：US20090099165A1

公开(公告)日：2009-04-16

申请号：US11735344

申请日：2007-04-13

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/5377 ,  C07D487/04 ,  A61K31/519

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

公开(公告)号：US20110212929A1

公开(公告)日：2011-09-01

申请号：US13051790

申请日：2011-03-18

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/635 ,  C07D487/04 ,  A61K31/496 ,  C07D471/14 ,  A61K31/519 ,  C07D413/14 ,  A61K31/5377 ,  A61P35/00

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20090143399A1

公开(公告)日：2009-06-04

申请号：US11841574

申请日：2007-08-20

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  Haiyong Han ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Ruben M. Munoz ,  Steven L. Warner ,  Kimiko Della Croce ,  Daniel D. Von Hoff ,  Cory L. Grand ,  James Welsh

IPC分类号： A61K31/496 ,  C07D487/04 ,  C07D495/14 ,  C07D491/048 ,  A61P35/04

CPC分类号： C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US08552018B2

公开(公告)日：2013-10-08

申请号：US13051790

申请日：2011-03-18

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner ,  James Welsh

IPC分类号： A61K31/519 ,  A61K31/496 ,  A61P35/04 ,  C07D491/14 ,  C07D471/14 ,  C07D239/70 ,  A61K31/517

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US07312226B2

公开(公告)日：2007-12-25

申请号：US11092168

申请日：2005-03-29

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner

IPC分类号： A61K31/519 ,  C07D487/14 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07D239/94 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明的化合物具有以下结构：包括立体异构体，其前药和药学上可接受的盐，其中A是选自以下的环部分：其中R 1，R 2，R 3，X，Z，L 1，Cyc 11， L 2和Cyc 2如本文所定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US07326713B2

公开(公告)日：2008-02-05

申请号：US11092809

申请日：2005-03-29

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner

IPC分类号： A61K31/519 ,  C07D487/14 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07D239/94 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US07335662B2

公开(公告)日：2008-02-26

申请号：US11092863

申请日：2005-03-29

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner

IPC分类号： A61K31/519 ,  C07D487/14 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07D239/94 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

公开(公告)号：US07326712B2

公开(公告)日：2008-02-05

申请号：US10965313

申请日：2004-10-14

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Sridevi Bashyam ,  Steven L. Warner

IPC分类号： C07D471/14 ,  A61K31/519 ,  A61P35/04 ,  C07D239/70 ,  A61K31/517

CPC分类号： C07D487/04 ,  C07D239/94 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20130302303A1

公开(公告)日：2013-11-14

申请号：US13947691

申请日：2013-07-22

申请人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Steven L. Warner ,  James Welsh

发明人： Laurence H. Hurley ,  Daruka Mahadevan ,  David J. Bearss ,  Hariprasad Vankayalapati ,  Steven L. Warner ,  James Welsh

IPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D491/048

CPC分类号： A61K31/519 ,  A61K45/06 ,  A61N5/00 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了可用于治疗蛋白激酶介导的疾病和病症（例如癌症）的蛋白激酶抑制剂。 本发明化合物具有以下结构：包括立体异构体，前体药物和药学上可接受的盐，其中A是选自以下的环部分：其中R1，R2，R3，X，Z，L1，Cyc11，L2和Cyc22为 本文定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。

公开(公告)号：US20080207632A1

公开(公告)日：2008-08-28

申请号：US11932617

申请日：2007-10-31

申请人： David J. Bearss ,  Cory L. Grand ,  Xiao-Hui Liu ,  Hariprasad Vankayalapati

发明人： David J. Bearss ,  Cory L. Grand ,  Xiao-Hui Liu ,  Hariprasad Vankayalapati

IPC分类号： A61K31/496 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D403/04

摘要： Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer, such as Aurora kinase-expressing cancers and Axl kinase-expressing cancers. Compounds of the invention have the following structure: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Z, L2 and w are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

摘要翻译： 公开了蛋白激酶抑制剂可用于治疗蛋白激酶介导的疾病和病症，例如癌症，例如表达极光激酶的癌症和表达Ax1激酶的癌症。 本发明的化合物具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中R 1，R 2，R 3， X，Z，L 2和W如本文所定义。 还公开了含有本发明化合物的组合物以及与其用途有关的方法。