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    Inhibitors of Bruton's tyrosine kinase
    2.
    发明授权
    Inhibitors of Bruton's tyrosine kinase 有权
    Bruton酪氨酸激酶抑制剂

    公开(公告)号：US08497277B2

    公开(公告)日：2013-07-30

    申请号：US13312606

    申请日：2011-12-06

    申请人： Lee Honigberg ,  Erik Verner ,  Zhengying Pan

    发明人： Lee Honigberg ,  Erik Verner ,  Zhengying Pan

    IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

    CPC分类号： A61K31/52 ,  A61K9/4825 ,  A61K31/00 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  A61K2300/00 ,  C07D487/04 ,  C07K16/2887 ,  C07K2317/24

    摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    摘要翻译： 本文公开了与布鲁顿酪氨酸激酶（Btk）形成共价键的化合物。 还描述了Btk的不可逆抑制剂。 公开了制备化合物的方法。 还公开了包含化合物的药物组合物。 公开了使用Btk抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。

    Inhibitors of bruton'S tyrosine kinase
    5.
    发明授权
    Inhibitors of bruton'S tyrosine kinase 有权
    bruton的酪氨酸激酶抑制剂

    公开(公告)号：US08232280B2

    公开(公告)日：2012-07-31

    申请号：US13011258

    申请日：2011-01-21

    申请人： Lee Honigberg ,  Erik Verner ,  Zhengying Pan

    发明人： Lee Honigberg ,  Erik Verner ,  Zhengying Pan

    IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

    CPC分类号： A61K31/52 ,  A61K9/4825 ,  A61K31/00 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  A61K2300/00 ,  C07D487/04 ,  C07K16/2887 ,  C07K2317/24

    摘要： Disclosed herein are pyrazolo[3,4-d]pyrimidines that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    摘要翻译： 本文公开了与布鲁特酪氨酸激酶（Btk）形成共价键的吡唑并[3,4-d]嘧啶。 还描述了Btk的不可逆抑制剂。 公开了制备化合物的方法。 还公开了包含化合物的药物组合物。 公开了使用Btk抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。

    Inhibitors of Bruton's tyrosine kinase
    8.
    发明授权
    Inhibitors of Bruton's tyrosine kinase 有权
    Bruton酪氨酸激酶抑制剂

    公开(公告)号：US08158786B2

    公开(公告)日：2012-04-17

    申请号：US13161238

    申请日：2011-06-15

    申请人： Lee Honigberg ,  Erik Verner ,  Zhengying Pan

    发明人： Lee Honigberg ,  Erik Verner ,  Zhengying Pan

    IPC分类号： C07D487/00

    CPC分类号： A61K31/52 ,  A61K9/4825 ,  A61K31/00 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  A61K2300/00 ,  C07D487/04 ,  C07K16/2887 ,  C07K2317/24

    摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    摘要翻译： 本文公开了与布鲁顿酪氨酸激酶（Btk）形成共价键的化合物。 还描述了Btk的不可逆抑制剂。 公开了制备化合物的方法。 还公开了包含化合物的药物组合物。 公开了使用Btk抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。

    Inhibitors of bruton's tyrosine kinase
    9.
    发明授权
    Inhibitors of bruton's tyrosine kinase 有权
    布鲁特酪氨酸激酶抑制剂

    公开(公告)号：US08754091B2

    公开(公告)日：2014-06-17

    申请号：US13542440

    申请日：2012-07-05

    申请人： Lee Honigberg ,  Erik Verner ,  Zhengying Pan

    发明人： Lee Honigberg ,  Erik Verner ,  Zhengying Pan

    IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

    CPC分类号： A61K31/52 ,  A61K9/4825 ,  A61K31/00 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  A61K2300/00 ,  C07D487/04 ,  C07K16/2887 ,  C07K2317/24

    摘要： Disclosed herein are compounds, including compounds having the structure of Formula (A), (B), (C), and (D), as described in further detail herein, that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    摘要翻译： 本文公开的是化合物，包括具有式（A），（B），（C）和（D）结构的化合物，如本文进一步详细描述的，与Bruton酪氨酸激酶（Btk）形成共价键。 还描述了Btk的不可逆抑制剂。 公开了制备化合物的方法。 还公开了包含化合物的药物组合物。 公开了使用Btk抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。

    Inhibitors of Bruton's tyrosine kinase
    10.
    发明授权
    Inhibitors of Bruton's tyrosine kinase 有权
    Bruton酪氨酸激酶抑制剂

    公开(公告)号：US08748438B2

    公开(公告)日：2014-06-10

    申请号：US13340409

    申请日：2011-12-29

    申请人： Lee Honigberg ,  Erik Verner ,  Zhengying Pan

    发明人： Lee Honigberg ,  Erik Verner ,  Zhengying Pan

    IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

    CPC分类号： A61K31/52 ,  A61K9/4825 ,  A61K31/00 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  A61K2300/00 ,  C07D487/04 ,  C07K16/2887 ,  C07K2317/24

    摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk, such as those having the structure of Formula (A) Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    摘要翻译： 本文公开了与布鲁顿酪氨酸激酶（Btk）形成共价键的化合物。 还描述了Btk的不可逆抑制剂，例如具有式（A）结构的抑制剂。公开了制备化合物的方法。 还公开了包含化合物的药物组合物。 公开了使用Btk抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。