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    Fused heterocyclic compounds
    4.
    发明授权
    Fused heterocyclic compounds 失效
    稠合杂环化合物

    公开(公告)号：US06809104B2

    公开(公告)日：2004-10-26

    申请号：US10289933

    申请日：2002-11-06

    申请人： Xiaoqi Chen ,  Pingchen Fan ,  Juan Jaen ,  Leping Li ,  Mike Lizarzaburu ,  Jeffrey Thomas Mihalic ,  Stephen Joseph Shuttleworth

    发明人： Xiaoqi Chen ,  Pingchen Fan ,  Juan Jaen ,  Leping Li ,  Mike Lizarzaburu ,  Jeffrey Thomas Mihalic ,  Stephen Joseph Shuttleworth

    IPC分类号： C07D47104

    CPC分类号： C07D471/04

    摘要： Compounds having the formula: wherein L is a bond or (C1-C4)alkylene, R″ is hydrogen or (C1-C8)alkyl, and R1, R2, R4, R, R′, and the subscript n are as described herein, are provided, which are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor, such as eating disorders, obesity, anxiety disorders and mood disorders, are also provided.

    摘要翻译： 具有下式的化合物：其中L是一个键或（C 1 -C 4）亚烷基，R“是氢或（C 1 -C 8）烷基，R 1，R 2，R 4，R，R '和下标n如本文所述，其可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症。 还提供了使用这些化合物治疗和/或预防由G蛋白偶联受体介导的病症或病症的药物组合物和方法，例如进食障碍，肥胖症，焦虑障碍和情绪障碍。

    Fused heterocyclic compounds
    7.
    发明授权
    Fused heterocyclic compounds 失效
    稠合杂环化合物

    公开(公告)号：US06858619B2

    公开(公告)日：2005-02-22

    申请号：US10138279

    申请日：2002-05-03

    申请人： Xiaoqi Chen ,  Kang Dai ,  Pingchen Fan ,  Shugui Huang ,  Leping Li ,  Jeffrey Thomas Mihalic

    发明人： Xiaoqi Chen ,  Kang Dai ,  Pingchen Fan ,  Shugui Huang ,  Leping Li ,  Jeffrey Thomas Mihalic

    IPC分类号： A61K31/437 ,  A61K31/5377 ,  A61K31/541 ,  A61P1/14 ,  A61P3/04 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： Compounds useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor are provided that have the formula: wherein A and B are CR′; V is either a bond and W is —N(R″)—, or else V is —N(R″)— and W is a bond; Z is —N(R)—CH2—; R1, R2, R3, R4, R′, R″, and R are as defined herein; the subscript n is an integer from 0 to 8; and  is a benzene ring. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders, are also provided.

    摘要翻译： 提供了可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症的化合物，其具有下式：其中A和B是CR'; V是键，W是-N（R“ ） - ，或者V是-N（R“） - ，W是键; Z是-N（R）-CH 2 - ; R 1，R 2，R 3，R 4 >，R'，R“和R如本文所定义;下标n是0至8的整数; 并且是苯环。还提供了使用这些化合物用于治疗和/或预防进食障碍，肥胖，焦虑障碍和情绪障碍的药物组合物和方法。