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公开(公告)号:US20130316385A1
公开(公告)日:2013-11-28
申请号:US13619387
申请日:2012-09-14
申请人: Lewis C. Cantley , Leonard Luan C Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
发明人: Lewis C. Cantley , Leonard Luan C Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
IPC分类号: C12Q1/32
CPC分类号: C12Q1/32 , A61K31/4184 , A61K31/428 , A61K31/519 , A61K31/5377 , A61K45/06 , A61K48/00 , C12N9/0006 , C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
摘要: Methods and compositions for treating and evaluating subjects having a neoactive mutation at residue 97 of IDH1 or 137 of IDH2.
摘要翻译: 用于治疗和评估IDH2的IDH1或137残基97具有新突变的受试者的方法和组合物。
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2.Method for diagnosing cell proliferation disorders having a neoactive mutation at residue 97 of isocitrate dehydrogenase 1 有权
标题翻译: 用于诊断在异柠檬酸脱氢酶1的残基97处具有新生突变的细胞增殖紊乱的方法公开(公告)号:US08883438B2
公开(公告)日:2014-11-11
申请号:US13619387
申请日:2012-09-14
申请人: Lewis C. Cantley , Leonard Luan C Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
发明人: Lewis C. Cantley , Leonard Luan C Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
IPC分类号: C12Q1/32
CPC分类号: C12Q1/32 , A61K31/4184 , A61K31/428 , A61K31/519 , A61K31/5377 , A61K45/06 , A61K48/00 , C12N9/0006 , C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
摘要: Methods and compositions for treating and evaluating subjects having a neoactive mutation at residue 97 of IDH1 or 137 of IDH2.
摘要翻译: 用于治疗和评估IDH2的IDH1或137残基97具有新突变的受试者的方法和组合物。
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公开(公告)号:US20130288284A1
公开(公告)日:2013-10-31
申请号:US13617332
申请日:2012-09-14
申请人: Leonard Luan C Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
发明人: Leonard Luan C Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
IPC分类号: C12Q1/32
CPC分类号: C12Q1/6886 , A61K31/015 , A61K31/05 , A61K31/122 , A61K31/194 , A61K31/225 , A61K31/355 , A61K31/375 , A61K31/381 , A61K31/522 , A61K31/7004 , A61K31/713 , A61K38/063 , A61K38/44 , C12Q1/32 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156
摘要: Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).
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4.
公开(公告)号:US20150240286A1
公开(公告)日:2015-08-27
申请号:US14504983
申请日:2014-10-02
申请人: Leonard Luan C Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
发明人: Leonard Luan C Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
IPC分类号: C12Q1/32
CPC分类号: C12Q1/6886 , A61K31/015 , A61K31/05 , A61K31/122 , A61K31/194 , A61K31/225 , A61K31/355 , A61K31/375 , A61K31/381 , A61K31/522 , A61K31/7004 , A61K31/713 , A61K38/063 , A61K38/44 , C12Q1/32 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156
摘要: Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).
摘要翻译: 治疗和评估具有IDH(例如,IDH1或IDH2)的新生突变体的受试者的方法。
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5.
公开(公告)号:US20140187435A1
公开(公告)日:2014-07-03
申请号:US13939519
申请日:2013-07-11
申请人: Leonard Luan C. Dang , Valeria Fantin , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Francesco Gerald Salituro , Jeffrey Owen Saunders , Shin-San Michael Su , Katharine Yen
发明人: Leonard Luan C. Dang , Valeria Fantin , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Francesco Gerald Salituro , Jeffrey Owen Saunders , Shin-San Michael Su , Katharine Yen
CPC分类号: A61B5/055 , A61K31/41 , A61K31/426 , A61K45/06 , C12N15/1137 , C12N2310/14 , C12Q1/32 , C12Q1/6886 , C12Y101/01042 , G01N33/574 , G06F19/328 , Y02A90/24 , Y02A90/26 , A61K2300/00
摘要: Methods of treating and evaluating subjects having neoactive mutants are described herein.
摘要翻译: 本文描述了治疗和评估具有新生突变体的受试者的方法。
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公开(公告)号:US09434979B2
公开(公告)日:2016-09-06
申请号:US13452136
申请日:2012-04-20
申请人: Shin-San Michael Su , Lenny Dang , Stefan Gross , Shengfang Jin , Valeria Fantin
发明人: Shin-San Michael Su , Lenny Dang , Stefan Gross , Shengfang Jin , Valeria Fantin
IPC分类号: A61K38/44 , C12Q1/32 , A61K31/225 , C12Q1/68 , A61K31/015 , A61K31/05 , A61K31/122 , A61K31/355 , A61K31/375 , A61K31/381 , A61K31/522 , A61K31/7004 , A61K31/713 , A61K38/06
CPC分类号: C12Q1/6886 , A61K31/015 , A61K31/05 , A61K31/122 , A61K31/194 , A61K31/225 , A61K31/355 , A61K31/375 , A61K31/381 , A61K31/522 , A61K31/7004 , A61K31/713 , A61K38/063 , A61K38/44 , C12Q1/32 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156
摘要: Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).
摘要翻译: 治疗和评估具有IDH(例如,IDH1或IDH2)的新生突变体的受试者的方法。
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公开(公告)号:US20130183281A1
公开(公告)日:2013-07-18
申请号:US13452136
申请日:2012-04-20
申请人: Shin-San Michael Su , Lenny Dang , Stefan Gross , Shengfang Jin , Valeria Fantin
发明人: Shin-San Michael Su , Lenny Dang , Stefan Gross , Shengfang Jin , Valeria Fantin
IPC分类号: A61K38/44 , A61K31/713 , A61K31/375 , A61K38/06 , A61K31/05 , A61K31/522 , A61K31/015 , A61K31/355 , A61K31/122 , A61K31/7004 , A61K31/381
CPC分类号: C12Q1/6886 , A61K31/015 , A61K31/05 , A61K31/122 , A61K31/194 , A61K31/225 , A61K31/355 , A61K31/375 , A61K31/381 , A61K31/522 , A61K31/7004 , A61K31/713 , A61K38/063 , A61K38/44 , C12Q1/32 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156
摘要: Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).
摘要翻译: 治疗和评估具有IDH(例如,IDH1或IDH2)的新生突变体的受试者的方法。
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公开(公告)号:US20170325708A1
公开(公告)日:2017-11-16
申请号:US15589615
申请日:2017-05-08
申请人: Lenny Dang , Valeria Fantin , Stefan Gross , Hyun G. Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shin-San Michael Su , Katharine Yen
发明人: Lenny Dang , Valeria Fantin , Stefan Gross , Hyun G. Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shin-San Michael Su , Katharine Yen
IPC分类号: A61B5/055 , G01N33/574 , C12Q1/68 , A61K31/426 , C12Q1/32 , C12N15/113 , A61K45/06 , G06F19/00 , A61K31/41
CPC分类号: A61B5/055 , A61K31/41 , A61K31/426 , A61K45/06 , C12N15/1137 , C12N2310/14 , C12Q1/32 , C12Q1/6886 , C12Y101/01042 , G01N33/574 , G06F19/328 , Y02A90/24 , Y02A90/26 , A61K2300/00
摘要: Methods of treating and evaluating subjects having neoactive mutants are described herein.
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9.
公开(公告)号:US20120121515A1
公开(公告)日:2012-05-17
申请号:US13256396
申请日:2010-03-12
申请人: Lenny Dang , Valeria Fantin , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shinsan Su , Katharine Yen
发明人: Lenny Dang , Valeria Fantin , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shinsan Su , Katharine Yen
CPC分类号: A61B5/055 , A61K31/41 , A61K31/426 , A61K45/06 , C12N15/1137 , C12N2310/14 , C12Q1/32 , C12Q1/6886 , C12Y101/01042 , G01N33/574 , G06F19/328 , Y02A90/24 , Y02A90/26 , A61K2300/00
摘要: Methods of treating and evaluating subjects having neoactive mutants are described herein.
摘要翻译: 本文描述了治疗和评估具有新生突变体的受试者的方法。
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公开(公告)号:US09493858B2
公开(公告)日:2016-11-15
申请号:US14235884
申请日:2012-06-15
申请人: Hans-Achim Kuhn , Andrea Kaeufler , Stefan Gross
发明人: Hans-Achim Kuhn , Andrea Kaeufler , Stefan Gross
IPC分类号: C22C9/04
CPC分类号: C22C9/04
摘要: A copper alloy subjected to a thermo-mechanical treatment and composed of (in wt %) 15.5 to 36.0% Zn, 0.3 to 3.0% Sn, 0.1 to 1.5% Fe, optionally 0.001 to 0.4% P, optionally 0.01 to 0.1% Al, optionally 0.01 to 0.03% Ag, Mg, Zr, In, Co, Cr, Ti, Mn, optionally 0.05 to 0.5% Ni, the remainder being copper and unavoidable contaminants, wherein the microstructure of the alloy is characterized in that the proportions of the main texture orientations are at least 10 vl % copper orientation, at least 10 vl % S/R orientation, at least 5 vl % brass orientation, at least 2 vl % Goss orientation, at least 2 vl % 22RD-cube orientation, at least 0.5 vl % cube orientation, and finely distributed iron-containing particles are contained in the alloy matrix.
摘要翻译: 进行热机械处理的铜合金,(重量%)Zn 15.5〜36.0%,Sn:0.3〜3.0%,Fe:0.1〜1.5%,Fe:0.001〜0.4%,Al:0.01〜0.1% 任选0.01至0.03%的Ag,Mg,Zr,In,Co,Cr,Ti,Mn,任选0.05至0.5%的Ni,其余为铜和不可避免的污染物,其中合金的微观结构的特征在于, 主要纹理取向至少为10v1%的铜取向,至少10vl%的S / R取向,至少5vl%的黄铜取向,至少2vl%的高斯取向,至少2vl%的22RD立方体取向,至少 0.5vl%立方体取向,并且在合金基体中含有细分布的含铁颗粒。
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