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    Three-phase tilting agitator for microarrays
    2.
    发明授权
    Three-phase tilting agitator for microarrays 有权
    用于微阵列的三相倾斜搅拌器

    公开(公告)号：US07578612B2

    公开(公告)日：2009-08-25

    申请号：US11194014

    申请日：2005-07-29

    申请人： Liang Zhang ,  Fei J. Xian ,  Renyuan Chen ,  Lianshan Zhao ,  Jianxing Ye ,  Xianhua Wang

    发明人： Liang Zhang ,  Fei J. Xian ,  Renyuan Chen ,  Lianshan Zhao ,  Jianxing Ye ,  Xianhua Wang

    IPC分类号： B01F11/00

    CPC分类号： B01F15/065 ,  B01F11/0028

    摘要： A low-cost, easy to operate, three-phase tilting agitator for microarrays, including large area microarrays, provides experimentally verified improvements in hybridization intensity and uniformity. Motion is coupled from a single motor to a sample holder via three suspension tethers. The microarrays may be immersed in a water bath during agitation to maintain a temperature for the hybridization reaction. The use of traditional cover slips for the microarrays minimizes the volume requirement for target sample solution.

    摘要翻译： 用于微阵列的低成本，易于操作的三相倾斜搅拌器，包括大面积微阵列，提供实验验证的杂交强度和均匀性的改进。 运动通过三个悬挂系绳从单个电机耦合到样品架。 在搅拌期间将微阵列浸入水浴中以保持杂交反应的温度。 对于微阵列使用传统的盖板可以最大限度地减少目标样品溶液的体积需求。

    Micro-Volume Liquid Ejection System
    3.
    发明申请
    Micro-Volume Liquid Ejection System 有权
    微量液体喷射系统

    公开(公告)号：US20080267828A1

    公开(公告)日：2008-10-30

    申请号：US11666032

    申请日：2004-11-22

    申请人： Dong Wang ,  Kun Zou ,  Jianxing Ye ,  Yelei Sun ,  Hui Zhu ,  Xianhua Wang ,  Jing Cheng

    发明人： Dong Wang ,  Kun Zou ,  Jianxing Ye ,  Yelei Sun ,  Hui Zhu ,  Xianhua Wang ,  Jing Cheng

    IPC分类号： B65D83/00

    CPC分类号： B01L3/0265 ,  B01L2400/0487 ,  B01L2400/0666 ,  Y10T436/2575

    摘要： The present invention relates to a micro-volume liquid ejection system, including an air pressure module, a micro-ejection unit which is connected with the air pressure module by means of pipes, and a control circuit which is connected with the air pressure module and the micro-ejection unit respectively. In the present invention, due to air is used as the pressure medium, on one hand, as the sample does not contact with the pressure regulating module, the efficiency of cleaning process is improved, on the other hand, the volume of the sample needed in the sample ejecting process is only equal to the cavity-dimension of the micro-ejection unit by not need to fill the whole pipe with liquid. During the sample ejecting process, it is not need to regulate the pressure. After the sample ejecting is finished, the sample can be put into its original place, so as to greatly save the sample. The present invention is connected with the manipulator, so as to sample from the sample plate, eject sample and clean the pipes automatically, and it can also dispense a multiplicity of samples to micro-array substrate conveniently. The present invention can be used for transferring or dispensing the micro volume liquid of nL grade and L grade widely, and all kinds of the micro-volume liquid including biological liquid.

    摘要翻译： 微体积液体喷射系统技术领域本发明涉及一种微体积液体喷射系统，包括空气压力模块，通过管道与空气压力模块连接的微型喷射单元，以及与气压模块连接的控制电路和 微型喷射单元。 在本发明中，由于空气被用作压力介质，一方面由于样品不与压力调节模块接触，因此提高了清洗过程的效率，另一方面，样品的体积需要 在样品喷射过程中，仅通过不需要用整个管道填充液体就等于微喷射单元的腔体尺寸。 在样品喷射过程中，不需要调节压力。 样品喷射完成后，样品可以放在原来的位置，大大节省样品。 本发明与机械手连接，从样品板上取样，自动排出样品并清洗管道，方便地将多个样品分配给微阵列基板。 本发明可广泛用于转移或分配nL级和L级微量液体，以及各种微体积液体，包括生物液体。

    Micro-volume liquid ejection system
    4.
    发明授权
    Micro-volume liquid ejection system 有权
    微量液体喷射系统

    公开(公告)号：US08900530B2

    公开(公告)日：2014-12-02

    申请号：US11666032

    申请日：2004-11-22

    申请人： Dong Wang ,  Kun Zou ,  Jianxing Ye ,  Yelei Sun ,  Hui Zhu ,  Xianhua Wang ,  Jing Cheng

    发明人： Dong Wang ,  Kun Zou ,  Jianxing Ye ,  Yelei Sun ,  Hui Zhu ,  Xianhua Wang ,  Jing Cheng

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0265 ,  B01L2400/0487 ,  B01L2400/0666 ,  Y10T436/2575

    摘要： The present invention relates to a micro-volume liquid ejection system, including an air pressure module, a micro-ejection unit which is connected with the air pressure module by a conduit, and a control circuit which is connected with the air pressure module and the micro-ejection unit respectively. The air is used as the pressure medium, resulting in improved cleaning process and reduced sample waste. The present invention includes an electric control circuit to pick up sample, eject sample and clean the conduits automatically, and enables handling of a multiplicity of samples. The present invention can be used for transferring or dispensing micro volume liquid including biological liquid on a nL and μL scale.

    摘要翻译： 微体积液体喷射系统技术领域本发明涉及一种微体积液体喷射系统，包括空气压力模块，通过导管与空气压力模块连接的微型喷射单元，以及与空气压力模块连接的控制电路， 微型喷射装置。 空气用作压力介质，从而改善清洗过程并减少样品废物。 本发明包括一个电子控制电路，用于拾取样品，抽出样品并自动清洁导管，并能够处理多个样品。 本发明可用于以nL和μL标度转移或分配包括生物液体的微量体积液体。

    Device for washing and hybridization of biochips
    8.
    发明授权
    Device for washing and hybridization of biochips 有权
    用于生物芯片的洗涤和杂交的装置

    公开(公告)号：US08137622B2

    公开(公告)日：2012-03-20

    申请号：US12527184

    申请日：2007-10-09

    申请人： Hang Li ,  Jianxin Ye ,  Xingling Al ,  Xianhua Wang ,  Liang Zhang ,  Jing Cheng

    发明人： Hang Li ,  Jianxin Ye ,  Xingling Al ,  Xianhua Wang ,  Liang Zhang ,  Jing Cheng

    IPC分类号： B01F11/00 ,  B01F11/04

    CPC分类号： B08B3/044 ,  B01F11/0028 ,  B01J2219/00326 ,  B01J2219/00328 ,  B01J2219/00527 ,  B01J2219/00659 ,  B01L7/00 ,  B01L2300/0819 ,  B08B11/02 ,  Y10S435/809

    摘要： A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.

    摘要翻译： 提供了用于生物芯片杂交或洗涤的装置，其包括圆盘传送带（12），平移运动控制器，旋转运动控制器和可选的加热室（13）。 旋转运动控制器控制圆盘传送带的旋转运动，并允许其以摆动的方式移动，允许杂交或洗涤盒（11）在传送带上的生物芯片的杂交和/或洗涤期间的液体移动。 一旦旋转运动控制器停止，平移运动控制器将转盘回到水平位置，从而确保液体不会溢出。 加热室在装置内循环热空气，从而确保在恒温条件下进行杂交和洗涤。

    DEVICE FOR WASHING AND HYBRIDIZATION OF BIOCHIPS
    9.
    发明申请
    DEVICE FOR WASHING AND HYBRIDIZATION OF BIOCHIPS 有权
    BIOCHIPS洗涤和杂交装置

    公开(公告)号：US20100190663A1

    公开(公告)日：2010-07-29

    申请号：US12527184

    申请日：2007-10-09

    申请人： Hang Li ,  Jianxin Ye ,  Xingling Al ,  Xianhua Wang ,  Liang Zhang ,  Jing Cheng

    发明人： Hang Li ,  Jianxin Ye ,  Xingling Al ,  Xianhua Wang ,  Liang Zhang ,  Jing Cheng

    IPC分类号： C40B60/00

    CPC分类号： B08B3/044 ,  B01F11/0028 ,  B01J2219/00326 ,  B01J2219/00328 ,  B01J2219/00527 ,  B01J2219/00659 ,  B01L7/00 ,  B01L2300/0819 ,  B08B11/02 ,  Y10S435/809

    摘要： A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.

    摘要翻译： 提供了用于生物芯片杂交或洗涤的装置，其包括圆盘传送带（12），平移运动控制器，旋转运动控制器和可选的加热室（13）。 旋转运动控制器控制圆盘传送带的旋转运动，并允许其以摆动的方式移动，允许杂交或洗涤盒（11）在传送带上的生物芯片的杂交和/或洗涤期间的液体移动。 一旦旋转运动控制器停止，平移运动控制器将转盘回到水平位置，从而确保液体不会溢出。 加热室在装置内循环热空气，从而确保在恒温条件下进行杂交和洗涤。

    Laser Confocal Microarray Scanner
    10.
    发明申请
    Laser Confocal Microarray Scanner 有权
    激光共聚焦微阵列扫描仪

    公开(公告)号：US20080252954A1

    公开(公告)日：2008-10-16

    申请号：US11795660

    申请日：2005-06-02

    申请人： Xianhua Wang ,  Hui Xu ,  Jianxin Ye ,  Yelei Sun ,  Guoliang Huang ,  Jing Cheng

    发明人： Xianhua Wang ,  Hui Xu ,  Jianxin Ye ,  Yelei Sun ,  Guoliang Huang ,  Jing Cheng

    IPC分类号： G02B26/08

    CPC分类号： G01N21/6458 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2201/10 ,  G01N2201/103

    摘要： The invention provides a laser microarray scanner for microarray scanning, comprising an optical system, a scanning platform, and a data processing system. During scanning, the optical system remains fixed, and the microarray placed on the scanning platform moves relative to the optical system. The microarray scanner disclosed herein has high scanning speed, high sensitivity, high resolution, and high signal-to-noise ratio, thus is ideal for use in microarray scanning

    摘要翻译： 本发明提供一种用于微阵列扫描的激光微阵列扫描器，包括光学系统，扫描平台和数据处理系统。 在扫描期间，光学系统保持固定，并且放置在扫描平台上的微阵列相对于光学系统移动。 本文公开的微阵列扫描器具有高扫描速度，高灵敏度，高分辨率和高信噪比，因此是理想的用于微阵列扫描