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公开(公告)号:US20060211677A1
公开(公告)日:2006-09-21
申请号:US10565604
申请日:2004-07-20
申请人: Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
发明人: Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
IPC分类号: C07D471/02 , C07D215/12 , C07D237/28 , A61K31/50 , A61K31/4965 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/4164 , A61K31/4745 , A61K31/433 , A61K31/4245
CPC分类号: C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要: The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents.
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公开(公告)号:US06077858A
公开(公告)日:2000-06-20
申请号:US401416
申请日:1999-09-21
申请人: Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人: Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号: C07D409/14 , C07D487/08 , A61K31/44
CPC分类号: C07D409/14 , C07D487/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US5985901A
公开(公告)日:1999-11-16
申请号:US83479
申请日:1998-05-22
申请人: Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人: Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号: C07D401/12 , C07D403/12 , C07D413/12 , C07D521/00 , A61K31/44
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D413/12
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US5981550A
公开(公告)日:1999-11-09
申请号:US83574
申请日:1998-05-22
申请人: Mark Goulet , Thomas F. Walsh , Feroze Ujjainwalla , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人: Mark Goulet , Thomas F. Walsh , Feroze Ujjainwalla , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号: C07D409/14 , C07D487/08 , C07D401/12 , A61K31/44
CPC分类号: C07D409/14 , C07D487/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US6150352A
公开(公告)日:2000-11-21
申请号:US180662
申请日:1998-11-12
申请人: Mark Goulet , Eric E Allen , Matthew J. Wyvratt, Jr. , Jinlong Jiang , Richard B. Toupence , Thomas F Walsh , Feroze Ujjainwalla , Jonathan R Young , Robert J. Devita
发明人: Mark Goulet , Eric E Allen , Matthew J. Wyvratt, Jr. , Jinlong Jiang , Richard B. Toupence , Thomas F Walsh , Feroze Ujjainwalla , Jonathan R Young , Robert J. Devita
IPC分类号: C07D473/00 , A61K31/00 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/529 , A61P5/00 , A61P5/06 , A61P5/24 , A61P15/00 , A61P25/20 , A61P35/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D453/02 , C07D473/32 , C07D487/04 , C07D487/08 , C07D495/04 , C07D31/47
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D473/32 , C07D487/04 , C07D495/04
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions in both men and women.
摘要翻译: PCT No.PCT / US97 / 08432 Sec。 371日期:1998年11月12日 102(e)1998年11月12日日期PCT提交1997年5月16日PCT公布。 公开号WO97 / 44339 日期1997年11月27日公开了可用作GnRH拮抗剂的式(I)化合物及其药学上可接受的盐,因此可用于治疗男性和女性中各种性激素相关病症。
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公开(公告)号:US6156772A
公开(公告)日:2000-12-05
申请号:US312192
申请日:1999-05-14
IPC分类号: A61K45/06 , C07D401/12 , C07D401/14 , C07D491/08 , A01N43/40 , A01N43/38 , C07D209/02 , C07D401/00 , C07D405/00
CPC分类号: C07D401/12 , A61K45/06 , C07D401/14 , C07D491/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US20060035935A1
公开(公告)日:2006-02-16
申请号:US11239721
申请日:2005-09-30
申请人: Mark Goulet , Ravi Nargund , Iyassu Sebhat , Feroze Ujjainwalla , Thomas Walsh , Daniel Warner , Zhixiong Ye , Jonathan Young , Raman Bakshi
发明人: Mark Goulet , Ravi Nargund , Iyassu Sebhat , Feroze Ujjainwalla , Thomas Walsh , Daniel Warner , Zhixiong Ye , Jonathan Young , Raman Bakshi
IPC分类号: A61K31/454 , C07D417/02 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号: C07D491/08 , A61K31/445 , C07D211/62 , C07D211/64 , C07D401/06 , C07D401/14 , C07D413/06 , C07D413/14
摘要: Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
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公开(公告)号:US20060025442A1
公开(公告)日:2006-02-02
申请号:US11239770
申请日:2005-09-30
申请人: Mark Goulet , Ravi Nargund , Feroze Ujjainwalla , Thomas Walsh , Daniel Warner
发明人: Mark Goulet , Ravi Nargund , Feroze Ujjainwalla , Thomas Walsh , Daniel Warner
IPC分类号: A61K31/4545 , A61K31/454 , C07D401/02
CPC分类号: C07D413/06 , C07D211/26 , C07D211/28 , C07D211/62 , C07D413/14
摘要: Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
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公开(公告)号:US20050267049A1
公开(公告)日:2005-12-01
申请号:US11153192
申请日:2005-06-15
申请人: Mark Goulet , Feroze Ujjainwalla , Anthony Ogawa , Derek Langen
发明人: Mark Goulet , Feroze Ujjainwalla , Anthony Ogawa , Derek Langen
IPC分类号: A61K31/397 , A61K31/7052 , A61P3/06 , A61P9/10 , C07D205/08 , C07H15/26
CPC分类号: C07D205/08 , C07H15/26
摘要: This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
摘要翻译: 本发明提供式I的胆固醇吸收抑制剂及其药学上可接受的盐和酯。 该化合物可用于降低血浆胆固醇水平,特别是低密度脂蛋白胆固醇,以及用于治疗和预防动脉粥样硬化和动脉粥样硬化疾病事件。
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公开(公告)号:US6004984A
公开(公告)日:1999-12-21
申请号:US83491
申请日:1998-05-22
IPC分类号: C07D409/14 , C07D487/08 , C07D401/12 , A61K31/44
CPC分类号: C07D409/14 , C07D487/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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