Inhibition of migration and induction of cell death by the type II collagen amino propeptides
    1.
    发明授权
    Inhibition of migration and induction of cell death by the type II collagen amino propeptides 有权
    通过II型胶原氨基前肽抑制迁移和诱导细胞死亡

    公开(公告)号:US08278266B2

    公开(公告)日:2012-10-02

    申请号:US12836832

    申请日:2010-07-15

    IPC分类号: A61K38/00

    CPC分类号: A61K38/39

    摘要: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an αvβ3 and/or an αvβ5 integrin.

    摘要翻译: 本发明提供诱导细胞死亡,抑制血管生成和抑制细胞迁移的组合和方法。 特别地,本发明提供了在表达αv&bgr 3和/或αv&bgr 5整合素的细胞中诱导细胞死亡的方法。

    INHIBITION OF MIGRATION AND INDUCTION OF CELL DEATH BY THE TYPE II COLLAGEN AMINO PROPEPTIDES
    2.
    发明申请
    INHIBITION OF MIGRATION AND INDUCTION OF CELL DEATH BY THE TYPE II COLLAGEN AMINO PROPEPTIDES 有权
    通过II型胶原氨基酸抑制剂移动和诱导细胞死亡

    公开(公告)号:US20120196364A1

    公开(公告)日:2012-08-02

    申请号:US13442352

    申请日:2012-04-09

    IPC分类号: C12N5/02

    CPC分类号: A61K38/39

    摘要: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an αvβ3 and/or an αvβ5 integrin.

    摘要翻译: 本发明提供诱导细胞死亡,抑制血管生成和抑制细胞迁移的组合和方法。 特别地,本发明提供了在表达αv&bgr 3和/或αv&bgr 5整合素的细胞中诱导细胞死亡的方法。

    Inhibition of migration and induction of cell death by the type II collagen amino propeptides
    3.
    发明授权
    Inhibition of migration and induction of cell death by the type II collagen amino propeptides 有权
    通过II型胶原氨基前肽抑制迁移和诱导细胞死亡

    公开(公告)号:US07851436B2

    公开(公告)日:2010-12-14

    申请号:US12098942

    申请日:2008-04-07

    IPC分类号: A61K38/00

    CPC分类号: A61K38/39

    摘要: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an αvβ3 and/or an αvβ5 integrin.

    摘要翻译: 本发明提供诱导细胞死亡,抑制血管生成和抑制细胞迁移的组合和方法。 特别地,本发明提供了在表达αv&bgr 3和/或αv&bgr 5整合素的细胞中诱导细胞死亡的方法。

    INHIBITION OF MIGRATION AND INDUCTION OF CELL DEATH BY THE TYPE II COLLAGEN AMINO PROPEPTIDES
    4.
    发明申请
    INHIBITION OF MIGRATION AND INDUCTION OF CELL DEATH BY THE TYPE II COLLAGEN AMINO PROPEPTIDES 有权
    通过II型胶原氨基酸抑制剂移动和诱导细胞死亡

    公开(公告)号:US20080300168A1

    公开(公告)日:2008-12-04

    申请号:US12098942

    申请日:2008-04-07

    IPC分类号: A61K38/02 C12N5/06

    CPC分类号: A61K38/39

    摘要: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an αvβ3 and/or an αvβ5 integrin.

    摘要翻译: 本发明提供诱导细胞死亡,抑制血管生成和抑制细胞迁移的组合和方法。 特别地,本发明提供了在表达α1β和/或alphavbeta5整联蛋白的细胞中诱导细胞死亡的方法。

    Inhibition of migration and induction of cell death by the type II collagen amino propeptides
    5.
    发明授权
    Inhibition of migration and induction of cell death by the type II collagen amino propeptides 有权
    通过II型胶原氨基前肽抑制迁移和诱导细胞死亡

    公开(公告)号:US08435937B2

    公开(公告)日:2013-05-07

    申请号:US13442352

    申请日:2012-04-09

    IPC分类号: A61K38/00

    CPC分类号: A61K38/39

    摘要: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an αvβ3 and/or an αvβ5 integrin.

    摘要翻译: 本发明提供诱导细胞死亡,抑制血管生成和抑制细胞迁移的组合和方法。 特别地,本发明提供了在表达α1β和/或alphavbeta5整联蛋白的细胞中诱导细胞死亡的方法。

    Trimerizing Polypeptides and Their Uses
    7.
    发明申请
    Trimerizing Polypeptides and Their Uses 审中-公开
    三聚多肽及其用途

    公开(公告)号:US20080166798A1

    公开(公告)日:2008-07-10

    申请号:US10569246

    申请日:2004-08-21

    IPC分类号: C12N5/00 C07K14/00 C07H21/04

    CPC分类号: C07K14/78

    摘要: A method for trimerizing collagenous molecule monomers comprising the step of contacting a collagen domain and a non-collagenous trimerization domain is provided. In addition, methods of trimerizing heterologous peptides is provided. Trimerizing polypeptides, vectors, cells, and trimerized polypeptides are also provided.

    摘要翻译: 提供了一种使胶原分子单体三聚的方法,其包括使胶原结构域和非胶原三聚体结构域接触的步骤。 此外,提供了异源多肽的三聚方法。 还提供了三聚化多肽,载体,细胞和三聚体多肽。

    UNCOUPLED COLLAGEN SYNTHESIS AND DEGRADATION ASSAYS
    8.
    发明申请
    UNCOUPLED COLLAGEN SYNTHESIS AND DEGRADATION ASSAYS 有权
    解开胶原蛋白合成和降解测定

    公开(公告)号:US20070292892A1

    公开(公告)日:2007-12-20

    申请号:US11758471

    申请日:2007-06-05

    IPC分类号: G01N33/53

    摘要: The invention relates to methods for determining the progression of cartilage degeneration diseases, such as osteoarthritis and rheumatoid arthritis, by quantitating collagen synthesis and degradation markers in patient samples. One can determine whether a cartilage degeneration condition is progressing, regressing, or remaining stable by quantitating collagen synthesis and degradation markers in patient samples and comparing the value obtained to a reference value. When a joint affected by cartilage degeneration in question expresses collagen synthesis and degradation markers, a change in this value is indicative of a change in the progression of the cartilage degeneration condition. The methods and apparatus of the invention allow accurate determination of the therapeutic effects certain cartilage degeneration drug treatments, including osteoarthritis and rheumatoid arthritis drug treatments, so are also useful for pharmaceutical efficacy studies in mammals.

    摘要翻译: 本发明涉及通过量化患者样品中的胶原合成和降解标记来测定软骨变性疾病如骨关节炎和类风湿性关节炎的进展的方法。 可以通过定量测定患者样品中的胶原合成和降解标记来确定软骨变性状态是否正在进行,回归或保持稳定,并将获得的值与参考值进行比较。 当受到软骨退化影响的关节表达胶原蛋白合成和降解标记物时,该值的变化表明软骨退化病情进展的变化。 本发明的方法和装置允许精确测定某些软骨变性药物治疗(包括骨关节炎和类风湿关节炎药物治疗)的治疗效果,因此也可用于哺乳动物的药物功效研究。