公开(公告)号：US07612883B2

公开(公告)日：2009-11-03

申请号：US11749950

申请日：2007-05-17

申请人： Long Que ,  Jeffrey Bernard Fortin ,  Christopher Fred Keimel ,  Liming Yu ,  Zhiyong Wang

发明人： Long Que ,  Jeffrey Bernard Fortin ,  Christopher Fred Keimel ,  Liming Yu ,  Zhiyong Wang

IPC分类号： G01N21/25

CPC分类号： G01N21/648 ,  B01L3/5025 ,  B01L3/502761 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819

摘要： Disclosed herein is a plasmonics platform comprising a substrate; a plurality of periodically spaced nanoholes and/or nanoparticles disposed upon the substrate; wherein the average first order of periodicity between the nanoholes and/or the nanoparticles is about 5 to about 1,000 nm; and a microelectromechanical and/or a nanoelectromechanical system in operative communication with the substrate so as to vary the average first order of periodicity between the nanoholes and/or the nanoparticles.

摘要翻译： 本文公开了一种等离子体激元平台，其包括基底; 多个周期性间隔开的纳米孔和/或纳米颗粒设置在基底上; 其中所述纳米孔和/或纳米颗粒之间的平均一级周期为约5至约1000nm; 以及与所述基板操作性连通的微机电和/或纳米机电系统，以便改变所述纳孔与/或纳米颗粒之间的周期的平均一级。

公开(公告)号：US20080285039A1

公开(公告)日：2008-11-20

申请号：US11749950

申请日：2007-05-17

申请人： Long Que ,  Jeffrey Bernard Fortin ,  Christopher Fred Keimel ,  Liming Yu ,  Zhiyong Wang

发明人： Long Que ,  Jeffrey Bernard Fortin ,  Christopher Fred Keimel ,  Liming Yu ,  Zhiyong Wang

IPC分类号： G01N21/55

CPC分类号： G01N21/648 ,  B01L3/5025 ,  B01L3/502761 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819

摘要： Disclosed herein is a plasmonics platform comprising a substrate; a plurality of periodically spaced nanoholes and/or nanoparticles disposed upon the substrate; wherein the average first order of periodicity between the nanoholes and/or the nanoparticles is about 5 to about 1,000 nm; and a microelectromechanical and/or a nanoelectromechanical system in operative communication with the substrate so as to vary the average first order of periodicity between the nanoholes and/or the nanoparticles.

摘要翻译： 本文公开了一种等离子体激元平台，其包括基底; 多个周期性间隔开的纳米孔和/或纳米颗粒设置在基底上; 其中所述纳米孔和/或纳米颗粒之间的平均一级周期为约5至约1000nm; 以及与所述基板操作性连通的微机电和/或纳米机电系统，以便改变所述纳孔与/或纳米颗粒之间的周期的平均一级。

公开(公告)号：US07411670B2

公开(公告)日：2008-08-12

申请号：US11400863

申请日：2006-04-10

申请人： Anis Zribi ,  Ayan Banerjee ,  Shivappa Ningappa Goravar ,  Shankar (nmn) Chandrasekaran ,  Sandip Maity ,  Glenn Scott Claydon ,  Stacey Joy Kennerly ,  Todd Ryan Tolliver ,  David Cecil Hays ,  Sheila Neumann Tandon ,  Long Que ,  Christopher Fred Keimel

发明人： Anis Zribi ,  Ayan Banerjee ,  Shivappa Ningappa Goravar ,  Shankar (nmn) Chandrasekaran ,  Sandip Maity ,  Glenn Scott Claydon ,  Stacey Joy Kennerly ,  Todd Ryan Tolliver ,  David Cecil Hays ,  Sheila Neumann Tandon ,  Long Que ,  Christopher Fred Keimel

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01J3/02 ,  G01J3/0291 ,  G01N21/65

摘要： A photonic crystal based collection probe is provided. The probe includes a photonic crystal configured to guide and condition a beam of Raman scattered photons. Further, the device includes a spectrograph in optical communication with the photonic crystal and configured to receive Raman scattering from the photonic crystal. The device may be employed in a Raman spectrometer system.

摘要翻译： 提供了一种基于光子晶体的收集探针。 探针包括配置为引导和调节拉曼散射光子束的光子晶体。 此外，该装置包括与光子晶体光学通信并被配置为从光子晶体接收拉曼散射的光谱仪。 该装置可以用在拉曼光谱仪系统中。

公开(公告)号：US20100059120A1

公开(公告)日：2010-03-11

申请号：US12208445

申请日：2008-09-11

申请人： Wei-Cheng Tian ,  Jeffrey Bernard Fortin ,  Jun Xie ,  Barbara Grossman ,  Oliver Charles Boomhower ,  Shashi Thutupalli ,  Long Que

发明人： Wei-Cheng Tian ,  Jeffrey Bernard Fortin ,  Jun Xie ,  Barbara Grossman ,  Oliver Charles Boomhower ,  Shashi Thutupalli ,  Long Que

IPC分类号： G01N33/00

CPC分类号： B01L3/502738 ,  B01L3/502707 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2300/0874 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0475 ,  B01L2400/0655 ,  B01L2400/0672 ,  Y10T137/0318

摘要： Methods and microfluidic devices for generating and manipulating sample droplets, wherein the devices comprise, a plurality of fluid channels, at least one of which is a sample channel for carrying a fluidic sample material, that is in fluid communication with the carrier fluid channel via an orifice; and an actuated flow interrupter adapted to force a predetermined amount of the sample fluid from the sample channel through the orifice into the carrier fluid channel.

摘要翻译： 用于产生和操纵样品液滴的方法和微流体装置，其中所述装置包括多个流体通道，其中至少一个流体通道是用于承载流体样品材料的样品通道，其经由载体流体通道流体连通 孔; 以及致动流动断路器，其适于将预定量的样品流体从样品通道穿过所述孔进入载体流体通道。

公开(公告)号：US20100220331A1

公开(公告)日：2010-09-02

申请号：US11447779

申请日：2006-06-06

申请人： Anis Zribi ,  Glenn S. Claydon ,  David C. Hays ,  Stacey Kennerly ,  Long Que ,  Shankar Chandrasekaran ,  Shivappa Goravar ,  Ayan Banerjee

发明人： Anis Zribi ,  Glenn S. Claydon ,  David C. Hays ,  Stacey Kennerly ,  Long Que ,  Shankar Chandrasekaran ,  Shivappa Goravar ,  Ayan Banerjee

IPC分类号： G01J3/45 ,  G02B26/00

CPC分类号： G01J3/26 ,  G01J3/06 ,  G02B26/001

摘要： According to some embodiments, a micro-electrical mechanical system apparatus includes an actuator within a plane and at least one movable mirror oriented substantially normal to the plane. The actuator may move the movable mirror with respect to a fixed mirror oriented substantially normal to the plane and substantially parallel to the movable mirror. The space between the fixed and movable mirrors might comprise, for example, a Fabry-Perot filter cavity for a spectrometer.

摘要翻译： 根据一些实施例，微电机械系统装置包括在平面内的致动器和基本上垂直于该平面定向的至少一个可移动镜。 致动器可以相对于基本上垂直于平面定向并且基本上平行于可移动镜的固定镜移动可移动镜。 固定镜和可移动镜之间的空间可以包括例如用于光谱仪的法布里 - 珀罗滤光腔。

公开(公告)号：US20100182608A1

公开(公告)日：2010-07-22

申请号：US11502187

申请日：2006-08-10

申请人： Anis Zribi ,  Glenn S. Claydon ,  Long Que ,  Stacey Kennerly ,  Shankar Chandrasekaran ,  Shivappa Goravar ,  David C. Hays ,  Ayan Banerjee

发明人： Anis Zribi ,  Glenn S. Claydon ,  Long Que ,  Stacey Kennerly ,  Shankar Chandrasekaran ,  Shivappa Goravar ,  David C. Hays ,  Ayan Banerjee

IPC分类号： G01J3/45 ,  G02B26/00

CPC分类号： G01J3/26 ,  G01J3/06 ,  G02B26/001

摘要： According to one embodiment, a micro-electrical mechanical system apparatus includes (i) a comb drive actuator having at least one irregularly shaped finger and (ii) a movable Fabry-Perot filter cavity mirror coupled to the comb drive actuator. According to some embodiments, a relationship between a voltage applied to the comb drive actuator and an amount of displacement associated with the movable mirror is substantially linear.

摘要翻译： 根据一个实施例，微电机械系统装置包括（i）具有至少一个不规则形状的指状物的梳状驱动致动器和（ii）耦合到梳状驱动致动器的可移动的法布里 - 珀罗滤光镜反射镜。 根据一些实施例，施加到梳状驱动致动器的电压与与可移动镜相关联的位移量之间的关系基本上是线性的。

公开(公告)号：US07586603B2

公开(公告)日：2009-09-08

申请号：US12104471

申请日：2008-04-17

申请人： Sandip Maity ,  Ayan Banerjee ,  Anis Zribi ,  Stacey Kennerly ,  Long Que ,  Glenn Claydon ,  Shankar Chandrasekaran ,  Shivappa Goravar

发明人： Sandip Maity ,  Ayan Banerjee ,  Anis Zribi ,  Stacey Kennerly ,  Long Que ,  Glenn Claydon ,  Shankar Chandrasekaran ,  Shivappa Goravar

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01J1/44 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0297 ,  G01J3/1895 ,  G01J3/4338 ,  G02B26/04 ,  H01L31/107

摘要： A method of Raman detection for a portable, integrated spectrometer instrument includes directing Raman scattered photons by a sample to an avalanche photodiode (APD), the APD configured to generate an output signal responsive to the intensity of the Raman scattered photons incident thereon. The output signal of the APD is amplified and passed through a discriminator so as to reject at least one or more of amplifier noise and dark noise. A number of discrete output pulses within a set operational range of the discriminator is counted so as to determine a number of photons detected by the APD.

摘要翻译： 用于便携式，集成光谱仪器的拉曼检测方法包括将样品的拉曼散射光子引导到雪崩光电二极管（APD），APD被配置为响应入射在其上的拉曼散射光子的强度产生输出信号。 APD的输出信号被放大并通过鉴频器，以便抑制至少一个或多个放大器噪声和暗噪声。 对鉴别器的设定操作范围内的多个离散输出脉冲进行计数，以便确定APD检测到的光子数量。

公开(公告)号：US07573578B2

公开(公告)日：2009-08-11

申请号：US11502189

申请日：2006-08-10

申请人： Anis Zribi ,  Glenn S. Claydon ,  David C. Hays ,  Stacey Kennerly ,  Long Que ,  Shankar Chandrasekaran ,  Shivappa Goravar ,  Ayan Banerjee

发明人： Anis Zribi ,  Glenn S. Claydon ,  David C. Hays ,  Stacey Kennerly ,  Long Que ,  Shankar Chandrasekaran ,  Shivappa Goravar ,  Ayan Banerjee

IPC分类号： G01B9/02

CPC分类号： G02B26/001

摘要： According to one embodiment, a micro-electrical mechanical system apparatus includes first and second mirrors that define a cavity. Moreover, a photonic band-gap structure coats a surface of at least one of the first or second mirrors to improve reflectivity. Another embodiment includes a third mirror, wherein the second and third mirrors form a second cavity. The spaces between the mirrors might comprise, for example, a pair of Fabry-Perot filter cavities for a spectrometer.

摘要翻译： 根据一个实施例，微机电系统装置包括限定空腔的第一和第二反射镜。 此外，光子带隙结构涂覆第一或第二反射镜中的至少一个的表面以提高反射率。 另一个实施例包括第三反射镜，其中第二和第三反射镜形成第二腔。 反射镜之间的空间可以包括例如用于光谱仪的一对法布里 - 珀罗滤光器空腔。

公开(公告)号：US20080204743A1

公开(公告)日：2008-08-28

申请号：US12104471

申请日：2008-04-17

申请人： Sandip Maity ,  Ayan Banerjee ,  Anis Zribi ,  Stacey Kennerly ,  Long Que ,  Glenn Claydon ,  Shankar Chandrasekaran ,  Shivappa Goravar

发明人： Sandip Maity ,  Ayan Banerjee ,  Anis Zribi ,  Stacey Kennerly ,  Long Que ,  Glenn Claydon ,  Shankar Chandrasekaran ,  Shivappa Goravar

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01J1/44 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0297 ,  G01J3/1895 ,  G01J3/4338 ,  G02B26/04 ,  H01L31/107

摘要： A method of Raman detection for a portable, integrated spectrometer instrument includes directing Raman scattered photons by a sample to an avalanche photodiode (APD), the APD configured to generate an output signal responsive to the intensity of the Raman scattered photons incident thereon. The output signal of the APD is amplified and passed through a discriminator so as to reject at least one or more of amplifier noise and dark noise. A number of discrete output pulses within a set operational range of the discriminator is counted so as to determine a number of photons detected by the APD.

公开(公告)号：US07142303B2

公开(公告)日：2006-11-28

申请号：US10937918

申请日：2004-09-10

申请人： Yogesh B. Gianchandani ,  Ghester G. Wilson ,  Long Que ,  Bhaskar Mitra ,  Ponnambalam Selvaganapathy

发明人： Yogesh B. Gianchandani ,  Ghester G. Wilson ,  Long Que ,  Bhaskar Mitra ,  Ponnambalam Selvaganapathy

IPC分类号： G01J3/10 ,  G01N21/64

CPC分类号： H01J61/58 ,  G01N21/645 ,  G01N21/67 ,  G01N21/69 ,  G01N2021/6417

摘要： A micro-discharge optical source apparatus and a method and system which utilizes the apparatus to analyze a sample are provided. The apparatus includes a substrate and an anode electrode and a cathode electrode supported on the substrate. One of the electrodes, such as the cathode, is preferably a liquid electrode. The electrodes are spaced apart to define an inter-electrode gap therebetween. The apparatus further includes a voltage source for applying a voltage between the electrodes sufficient to generate a glow micro-discharge in the gap to cause a first emission having a first desired excitation spectrum. An optical element is integrated with the substrate to direct the first emission to travel along an optical path including an axis. In one embodiment, the system detects the direct fluorescence of a sample such as tryptophan and other amino acids. In another embodiment, the system detects fluorescence of dye-labeled biochemicals.

摘要翻译： 提供一种微放电光源装置以及利用该装置分析样品的方法和系统。 该装置包括基板和支撑在基板上的阳极电极和阴极电极。 诸如阴极的电极之一优选为液体电极。 电极间隔开以限定它们之间的电极间间隙。 该装置还包括用于在电极之间施加足以在间隙中产生辉光微放电以产生具有第一期望激发光谱的第一发射的电压的电压源。 光学元件与衬底集成以引导第一发射沿着包括轴的光路行进。 在一个实施方案中，系统检测样品如色氨酸和其它氨基酸的直接荧光。 在另一个实施方案中，该系统检测染料标记的生物化学物质的荧光。