公开(公告)号：US20090047258A1

公开(公告)日：2009-02-19

申请号：US11659151

申请日：2005-08-02

申请人： Lucian V. Del Priore ,  Tongalp Tezel ,  Henry J. Kaplan

发明人： Lucian V. Del Priore ,  Tongalp Tezel ,  Henry J. Kaplan

IPC分类号： A61K35/12 ,  A61K38/16 ,  A61P17/00 ,  A61P27/02 ,  A61P25/00

CPC分类号： A61Q19/08 ,  A61K8/365 ,  A61K8/86 ,  A61K31/425

摘要： The invention is directed to compositions and methods for reversing age-related changes in extracellular matrix proteins, particularly the collagen framework of basement membranes of various organs. The invention has particular application to age-related changes that impair Retinal Pigment Epithelium (RPE) cell repopulation of human Bruch's membrane.

摘要翻译： 本发明涉及用于逆转细胞外基质蛋白的年龄相关变化的组合物和方法，特别是各种器官的基底膜的胶原骨架。 本发明特别适用于损害人类Bruch膜的视网膜色素上皮细胞（RPE）细胞再生的年龄相关变化。

公开(公告)号：US20100028407A1

公开(公告)日：2010-02-04

申请号：US12298698

申请日：2007-04-24

申请人： Lucian V. Del Priore ,  Henry J. Kaplan ,  Tongalp Tezel

发明人： Lucian V. Del Priore ,  Henry J. Kaplan ,  Tongalp Tezel

IPC分类号： A61K35/44 ,  C09J7/02 ,  A61K9/70 ,  A61F13/00 ,  A61P27/02 ,  A61K47/42 ,  A61K47/36 ,  A61K47/34 ,  A61K47/26 ,  A61P17/02

CPC分类号： A61L15/40 ,  A61L15/58 ,  Y10T428/266

摘要： The invention generally provides compositions and methods for promoting and enhancing wound closure and healing. Specifically, the invention provides a biologic composition which comprises a support layer which serves as transport scaffold, for example made of gelatin, which is coated or impregnated with a bio-adhesive molecule such as rose bengal or glyceraldehyde. The composition can also comprise an artificial or biological matrix, optionally processed (i.e. cleaned and coated with extracellular matrix proteins) to enhance cell attachment and survival. The composition can further comprise a monolayer of epithelial, endothelial cells or mesenchymal cells. The invention provides methods for using the compositions for treating wounds due to disease, trauma or surgery. Specific methods for treating ocular wounds are provided.

摘要翻译： 本发明通常提供用于促进和增强伤口闭合和愈合的组合物和方法。 具体而言，本发明提供了一种生物组合物，其包含用作运输支架的支撑层，例如由明胶制成，其用诸如玫瑰红或甘油醛的生物粘合剂分子包被或浸渍。 组合物还可以包含人造或生物基质，任选地加工（即清洁并涂覆有细胞外基质蛋白质）以增强细胞附着和存活。 组合物还可以包含单层的上皮，内皮细胞或间充质细胞。 本发明提供了使用该组合物治疗由于疾病，外伤或手术引起的伤口的方法。 提供了治疗眼部伤口的具体方法。