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公开(公告)号:US09499522B2
公开(公告)日:2016-11-22
申请号:US14210526
申请日:2014-03-14
申请人: Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
发明人: Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
IPC分类号: C07D403/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/04 , C07D487/08 , C07D401/12 , C07D403/04 , C07D403/14 , C07D239/94 , C07D487/22
CPC分类号: C07D403/14 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D473/34 , C07D487/04 , C07D487/08 , C07D487/22
摘要: Compounds and compositions useful for treating disorders related to Kit are described herein.
摘要翻译: 本文描述了可用于治疗与Kit相关的疾病的化合物和组合物。
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公开(公告)号:US20140296206A1
公开(公告)日:2014-10-02
申请号:US14210526
申请日:2014-03-14
申请人: Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
发明人: Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
IPC分类号: C07D403/12 , C07D487/08 , C07D413/14 , C07D409/14 , C07D405/14 , C07D487/04 , C07D401/14
CPC分类号: C07D403/14 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D473/34 , C07D487/04 , C07D487/08 , C07D487/22
摘要: Compounds and compositions useful for treating disorders related to Kit are described herein.
摘要翻译: 本文描述了可用于治疗与Kit相关的疾病的化合物和组合物。
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公开(公告)号:US09434700B2
公开(公告)日:2016-09-06
申请号:US14521909
申请日:2014-10-23
IPC分类号: C07D405/12 , A61K31/517 , C07D239/84 , C07D401/12 , C07D403/12 , C07D403/14 , C07D471/04 , C07D401/04 , C07D475/00 , C07D235/30 , C07D409/12 , C07D475/08
CPC分类号: C07D401/04 , C07D235/30 , C07D239/84 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D471/04 , C07D475/00
摘要: Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
摘要翻译: 本文描述的是FGFR-4的抑制剂,包括这些化合物的药物组合物,以及使用这些化合物和组合物的方法。
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公开(公告)号:US20150119405A1
公开(公告)日:2015-04-30
申请号:US14521909
申请日:2014-10-23
IPC分类号: C07D239/84 , C07D403/12 , C07D471/04 , C07D405/12 , C07D475/00 , C07D401/04
CPC分类号: C07D401/04 , C07D235/30 , C07D239/84 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D471/04 , C07D475/00
摘要: Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
摘要翻译: 本文描述的是FGFR-4的抑制剂,包括这些化合物的药物组合物,以及使用这些化合物和组合物的方法。
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公开(公告)号:US07435823B2
公开(公告)日:2008-10-14
申请号:US11042634
申请日:2005-01-24
申请人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , Gregory J. Habgood , David C. McGowan , Douglas A. Whittington , Daniel La , Vinod F. Patel
发明人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , Gregory J. Habgood , David C. McGowan , Douglas A. Whittington , Daniel La , Vinod F. Patel
IPC分类号: C07D215/38 , C07D265/34
CPC分类号: C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US08178557B2
公开(公告)日:2012-05-15
申请号:US12157303
申请日:2008-06-09
申请人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
发明人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
IPC分类号: A61K31/04
CPC分类号: C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US20090176774A1
公开(公告)日:2009-07-09
申请号:US12157303
申请日:2008-06-09
申请人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
发明人: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
IPC分类号: A61K31/536 , A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709
CPC分类号: C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号:US20150197519A1
公开(公告)日:2015-07-16
申请号:US14596987
申请日:2015-01-14
IPC分类号: C07D471/04 , C07D217/16 , C07D403/04 , C07D413/04 , C07D239/74
CPC分类号: C07D471/04 , A61K31/517 , C07D217/14 , C07D217/16 , C07D239/74 , C07D403/04 , C07D413/04 , C07D487/04 , C07D487/14
摘要: Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of FGFR-4.
摘要翻译: 本文描述了FGFR-4的抑制剂,包括这些化合物的药物组合物,以及使用这些化合物和组合物抑制FGFR-4活性的方法。
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公开(公告)号:US06864255B2
公开(公告)日:2005-03-08
申请号:US10120939
申请日:2002-04-10
IPC分类号: A61P35/00 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/04 , C07D417/14 , C07D251/16 , A61K31/53
CPC分类号: C07D401/04 , C07D251/18 , C07D401/14 , C07D403/04 , C07D417/14
摘要: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and angiogenesis-related disease.
摘要翻译: 本发明包括其化合物,类似物,前药和药学上可接受的盐,药物组合物,用于预防和治疗癌症和血管发生相关疾病的用途和方法。
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公开(公告)号:US07074789B2
公开(公告)日:2006-07-11
申请号:US10699518
申请日:2003-10-31
申请人: David M. Armistead , Jean E. Bemis , John L. Buchanan , Lucian V. DiPietro , Daniel Elbaum , Stephanie D. Geuns-Meyer , Gregory J. Habgood , Joseph L. Kim , Teresa L. Marshall , Perry M. Novak , Joseph J. Nunes , Vinod F. Patel , Leticia M. Toledo-Sherman , Xiaotian Zhu
发明人: David M. Armistead , Jean E. Bemis , John L. Buchanan , Lucian V. DiPietro , Daniel Elbaum , Stephanie D. Geuns-Meyer , Gregory J. Habgood , Joseph L. Kim , Teresa L. Marshall , Perry M. Novak , Joseph J. Nunes , Vinod F. Patel , Leticia M. Toledo-Sherman , Xiaotian Zhu
IPC分类号: C07D403/12 , C07D403/14 , A61K31/4155 , A61P35/04
CPC分类号: C07D401/04 , C07D251/18 , C07D251/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要: The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.
摘要翻译: 本发明涉及结合ATP或GTP和/或催化磷酸转移的酶抑制剂,包含抑制剂的组合物,以及使用抑制剂和抑制剂组合物的方法。 包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备磷酸转移酶抑制剂化合物的方法,抑制磷酸转移酶活性的方法,以及治疗疾病或疾病症状的方法。
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