摘要:
This invention relates to a process for the preparation of purified bacterial membranal proteoglycans. The process comprises at least one step in which crude proteoglycans are treated in aqueous medium with a base or a hypobromite, followed by elimination of the excess reactant and the insoluble residue, the purified proteoglycans being present in aqueous solution. The thus obtained purified proteoglycans may be used as immunity adjuvants in vaccines without causing side-effects such as pyrogenic reactions.
摘要:
The present invention relates to an aerosol composition containing a carrier agent capable of recognizing and binding to inflammatory and tumor foci mobilizing macrophages in their immediate environment, and an aerosol substrate, characterized in that the said carrier agent consists of a polysaccharide compound selected from the compound D 25, extracted from the membrane proteoglycans of the bacterium Klebsiella pneumoniae and having a molecular weight of 30.+-.0.10 Kd, and the compound oxidized D 25 in which the galactofuranoser residue (Gal.sub.f) of the linear polysaccharide chain of D 25 has been converted to arabinose, and their amide, ester or ether type derivatives, as well as their quaternary ammonium derivatives and salts, and also the derivatives obtained by grafting of phosphatides.
摘要翻译:本发明涉及一种含有能够识别和结合其直接环境中的炎性和肿瘤灶动员巨噬细胞的载体剂的气溶胶组合物,以及气溶胶底物,其特征在于所述载体剂由选自化合物 D 25,从肺炎克雷伯菌细菌的膜蛋白聚糖中提取,分子量为30 +/- 0.10Kd,D 25的直链多糖链的半乳糖醛酸残基(Galf)已经被氧化的D 25 转化成阿拉伯糖,以及它们的酰胺,酯或醚型衍生物,以及它们的季铵衍生物和盐,以及通过磷脂接枝获得的衍生物。
摘要:
The present invention relates to a polysaccharide derivative, which is a derivative of D.25 in which the galactofuranose (Gal.sub.f) residues of the linear polysaccharide chain have been converted at least partly to arabinose.It also relates to the process for its preparation, to its use as an immunostimulant, and to pharmaceutical compositions containing the derivative.
摘要:
Vaccines which comprise in association the ribosomal fraction extracted from the bacterias against which a protection is wanted, and the peptidoglycanes extracted from the membranes of at least one of the bacteria previously used.