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    Dynamically variable separation among nanoparticles for nano-enhanced Raman spectroscopy (NERS) molecular sensing
    1.
    发明授权
    Dynamically variable separation among nanoparticles for nano-enhanced Raman spectroscopy (NERS) molecular sensing 有权
    用于纳米增强拉曼光谱（NERS）分子感测的纳米颗粒之间的动态变化分离

    公开(公告)号：US07342656B2

    公开(公告)日：2008-03-11

    申请号：US11252134

    申请日：2005-10-17

    申请人： M. Saif Islam ,  Shih-Yuan Wang ,  R. Stanley Williams ,  Philip J. Kuekes ,  Wei Wu ,  Zhiyong Li

    发明人： M. Saif Islam ,  Shih-Yuan Wang ,  R. Stanley Williams ,  Philip J. Kuekes ,  Wei Wu ,  Zhiyong Li

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/658

    摘要： A NERS-active structure includes a deformable, active nanoparticle support structure for supporting a first nanoparticle and a second nanoparticle that is disposed proximate the first nanoparticle. The nanoparticles each comprise a NERS-active material. The deformable, active nanoparticle support structure is configured to vary the distance between the first nanoparticle and the second nanoparticle while performing NERS. Various active nanoparticle support structures are disclosed. A NERS system includes such a NERS-active structure, a radiation source for generating radiation scatterable by an analyte located proximate the NERS-active structure, and a radiation detector for detecting Raman scattered radiation scattered by the analyte. A method for performing NERS includes providing such a NERS-active structure, providing an analyte at a location proximate the NERS-active structure, irradiating the NERS-active structure and the analyte with radiation, varying the distance between the nanoparticles, and detecting Raman scattered radiation scattered by the analyte.

    摘要翻译： NERS活性结构包括用于支撑第一纳米颗粒的可变形的活性纳米颗粒支撑结构和邻近第一纳米颗粒设置的第二纳米颗粒。 纳米颗粒各自包含NERS-活性材料。 可变形的活性纳米颗粒支撑结构被配置为在执行NERS的同时改变第一纳米颗粒和第二纳米颗粒之间的距离。 公开了各种活性纳米颗粒载体结构。 NERS系统包括这样的NERS-活性结构，用于产生由位于NERS-活性结构附近的分析物可散射的辐射的辐射源，以及用于检测被分析物散射的拉曼散射辐射的辐射检测器。 执行NERS的方法包括提供这样的NERS活性结构，在靠近NERS-活性结构的位置提供分析物，用辐射照射NERS-活性结构和分析物，改变纳米颗粒之间的距离并检测拉曼散射 被分析物散射的辐射。

    Monolithic system and method for enhanced Raman spectroscopy
    3.
    发明授权
    Monolithic system and method for enhanced Raman spectroscopy 有权
    用于增强拉曼光谱的单片系统和方法

    公开(公告)号：US07151599B2

    公开(公告)日：2006-12-19

    申请号：US11044421

    申请日：2005-01-27

    申请人： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

    发明人： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/658 ,  G01N2201/0873

    摘要： Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed in a waveguide. The molecular analysis device also includes a wavelength demultiplexer and radiation sensors disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.

    摘要翻译： 公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。 用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。 激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。 拉曼增强结构可以设置在波导中。 该分子分析装置还包括布置在基板上的波长解复用器和辐射传感器，并且被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射。

    Integrated modular system and method for enhanced Raman spectroscopy
    4.
    发明授权
    Integrated modular system and method for enhanced Raman spectroscopy 有权
    用于增强拉曼光谱的集成模块化系统和方法

    公开(公告)号：US07385691B2

    公开(公告)日：2008-06-10

    申请号：US11044676

    申请日：2005-01-27

    申请人： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

    发明人： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/658 ,  G01J3/44 ,  H01L31/02325 ,  H01L31/105

    摘要： Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed on the substrate or apart from the substrate. The molecular analysis device also include a radiation receiver disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.

    摘要翻译： 公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。 用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。 激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。 拉曼增强结构可以设置在基板上或者离开基板。 分子分析装置还包括设置在基板上并被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射的辐射接收器。

    Method for arranging nanoparticles by way of an electric field, structures and systems therefor
    5.
    发明申请
    Method for arranging nanoparticles by way of an electric field, structures and systems therefor 审中-公开
    通过电场，结构和系统布置纳米颗粒的方法

    公开(公告)号：US20080093217A1

    公开(公告)日：2008-04-24

    申请号：US11584678

    申请日：2006-10-20

    申请人： Wei Wu ,  R. Stanley Williams ,  Shih-Yuan Wang ,  Philip J. Kuekes ,  Zhiyong Li

    发明人： Wei Wu ,  R. Stanley Williams ,  Shih-Yuan Wang ,  Philip J. Kuekes ,  Zhiyong Li

    IPC分类号： G01N27/26

    CPC分类号： G01N21/658

    摘要： A method of forming a plurality of NERS-active structures is disclosed. Particularly, a substrate having a surface and a liquid including nanoparticles is deposited on at least a portion of the surface of the substrate. At least one electric field may be generated proximate to the surface and at least a portion of the nanoparticles may be arranged via the electric field. A system includes at least two electrodes configured for producing at least one electric field for substantially arranging nanoparticles substantially according to a selected pattern. A NERS-active structure includes a substrate and a plurality of features located at predetermined positions on a surface of the substrate and at least one NERS-active nanoparticle at least partially embedded therein.

    摘要翻译： 公开了一种形成多个NERS-活性结构的方法。 特别地，具有表面和包含纳米颗粒的液体的基底沉积在基底表面的至少一部分上。 可以在表面附近产生至少一个电场，并且可以经由电场布置至少一部分纳米颗粒。 一种系统包括至少两个电极，所述至少两个电极被配置用于产生至少一个电场，用于基本上根据所选择的图案基本上布置纳米颗粒。 NERS活性结构包括基底和位于基底表面上的预定位置的多个特征以及至少部分地嵌入其中的至少一个NERS-活性纳米颗粒。

    DYNAMICALLY RECONFIGURABLE HOLOGRAMS
    10.
    发明申请
    DYNAMICALLY RECONFIGURABLE HOLOGRAMS 有权
    动态可重构的HOLOGRAMS

    公开(公告)号：US20110273755A1

    公开(公告)日：2011-11-10

    申请号：US13142484

    申请日：2008-12-29

    申请人： Shih-Yuan Wang ,  Alexandre M. Bratkovski ,  R. Stanley Williams ,  Jingjing Li ,  Wei Wu ,  Philip J. Kuekes

    发明人： Shih-Yuan Wang ,  Alexandre M. Bratkovski ,  R. Stanley Williams ,  Jingjing Li ,  Wei Wu ,  Philip J. Kuekes

    IPC分类号： G03H1/14 ,  H01L45/00 ,  B82Y99/00

    CPC分类号： G03H1/02 ,  G02B1/007 ,  G03H1/2249 ,  G03H1/2294 ,  G03H2001/0224 ,  G03H2210/30 ,  G03H2225/22 ,  G03H2225/32 ,  G03H2225/33

    摘要： Various embodiments of the present invention relate to systems that can be used as holograms and can be electronically controlled and dynamically reconfigured to generate three-dimensional motion picture images. In one embodiment, a dynamically reconfigurable hologram (1200) comprises a phase-control layer (1202) including a two-dimensional array of phase-modulation pixels (1212). The hologram also comprises an intensity-control layer (1204) including a two-dimensional array of intensity-control pixels (1214). One or more three-dimensional motion pictures can be produced by electronically addressing the individual phase-modulation pixels and intensity-control pixels in order to phase and control the intensity of light emanating from pixels of the hologram.

    摘要翻译： 本发明的各种实施例涉及可以用作全息图并且可以被电子控制和动态重新配置以产生三维运动图像图像的系统。 在一个实施例中，动态可重构全息图（1200）包括包括相位调制像素的二维阵列（1212）的相位控制层（1202）。 全息图还包括包括强度控制像素（1214）的二维阵列的强度控制层（1204）。 可以通过电子地寻址各个相位调制像素和强度控制像素来产生一个或多个三维运动图像，以便相位和控制从全息图像素发出的光的强度。