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19 条记录 (耗时 0.011 秒)

    Labile esters of ({31 )(cis-1,2-epoxypropyl)phosphonic
    5.
    发明授权
    Labile esters of ({31 )(cis-1,2-epoxypropyl)phosphonic 失效
    不饱和酯（{31）（顺式-1,2-环氧丙基）膦酸酯

    公开(公告)号：US3929840A

    公开(公告)日：1975-12-30

    申请号：US46033074

    申请日：1974-04-12

    申请人： MERCK & CO INC

    发明人： CHRISTENSEN BURTON G ,  LEANZA WILLIAM J ,  ALBERS-SCHONBERG GEORG

    IPC分类号： C07F9/655 ,  C07F9/40

    CPC分类号： C07F9/65505

    摘要： Labile esters of (-)(cis-1,2-epoxypropyl)phosphonic acid are prepared from the free acid or salts thereof by reaction with an alcohol or a hydrocarbyl halide. In addition to their utility as intermediates in the synthesis of antibacterially active salts of (-)(cis-1,2-epoxypropyl)phosphonic acid, those esters have significant antibacterial activity.

    摘要翻译： （ - ）（顺式-1,2-环氧丙基）膦酸的不定性酯由游离酸或其盐通过与醇或烃基卤化物反应制备。 除了它们作为（ - ）（顺式-1,2-环氧丙基）膦酸的抗菌活性盐的合成中间体的作用之外，这些酯具有显着的抗菌活性。

    Phosphanilic acid derivatives
    9.
    发明授权
    Phosphanilic acid derivatives 失效
    磷酸衍生物

    公开(公告)号：US3689480A

    公开(公告)日：1972-09-05

    申请号：US3689480D

    申请日：1969-08-05

    申请人： MERCK & CO INC

    发明人： CHRISTENSEN BURTON G ,  LEANZA WILLIAM J

    IPC分类号： C07F9/44 ,  C07D51/44 ,  A61K27/00

    CPC分类号： C07F9/4419

    摘要： FLUORO SUBSTITUTED PHOSPHANILIC AMIDES ARE PRODUCED BY REDUCTION OF THE CORRESPONDING FLUORO-NITROBENZENEPHOSPHONAMIDE. THE NITROBENZENEPHOSPHONAMIDES MAY BE PREPARED FROM THE PHOSPHONIC DIHALIDE BY REACTION OF THE DIHALIDE WITH AN AMINE. THE PHOSPHONIC DIHALIDE MAY BE PREPARED FROM THE CORRESPONDING FLUORO-SUBSTITUTED PHOSPHONIC ACID BY REACTION WITH A HALOGENATING AGENT. THE FLUORO-PHOSPHANILIC AMIDES ARE USEFUL AS ANTI-BACTERIAL AGENTS.