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公开(公告)号:US09718828B2
公开(公告)日:2017-08-01
申请号:US15250978
申请日:2016-08-30
发明人: Adrianus Petrus Antonius De Man , Jan-Gerard Sterrenburg , Hans C. A. Raaijmakers , Allard Kaptein , Arthur A. Oubrie , Johannes Bernardus Maria Rewinkel , Christiaan Gerardus Johannes Maria Jans , Jacobus C. H. M. Wijkmans , Tjeerd A. Barf , Alan B. Cooper , Ronald M. Kim , Sobhana Babu Boga , Hugh Y. Zhu , Xiaolei Gao , Xin Yao , Rajan Anand , Hao Wu , Shilan Liu , Chundao Yang , Abdul-Basit Alhassan , James Wang , Younong Yu , Jian Liu , Henry M. Vaccaro
IPC分类号: C07D487/04 , C07D497/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/52 , A61K31/53 , A61P19/02 , C07D519/00 , A61K45/06 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D513/04 , C07D471/04
CPC分类号: C07D487/04 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D513/04 , C07D519/00
摘要: Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.