公开(公告)号：US20220381780A1

公开(公告)日：2022-12-01

申请号：US17749721

申请日：2022-05-20

申请人： Meso Scale Technologies, LLC. ,  The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Jacob N. WOHLSTADTER ,  George SIGAL ,  James WILBUR ,  Jeffery DEBAD ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Christopher CAMPBELL ,  Anastasia AKSYUK ,  Adrian MCDERMOTT ,  Sarah O'CONNELL ,  Sandeep NARPALA ,  Chien Li LIN

IPC分类号： G01N33/569 ,  G01N33/543 ,  G01N33/58

摘要： The invention relates to methods and kits for determining a SARS-CoV-2 strain in a sample. The invention further provides methods and kits for detecting a single nucleotide polymorphism (SNP) in a target nucleic acid, wherein the target nucleic acid is a SARS-CoV-2 nucleic acid. The invention further provides methods and kits for detecting one or more antibody biomarkers in a sample.

公开(公告)号：US20210349104A1

公开(公告)日：2021-11-11

申请号：US17246364

申请日：2021-04-30

申请人： Meso Scale Technologies, LLC. ,  The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  James WILBUR ,  Jeffery DEBAD ,  Christopher CAMPBELL ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Pu LIU ,  Paul GOODWIN ,  Adrian MCDERMOTT ,  Sarah O'CONNELL ,  Sandeep NARPALA

IPC分类号： G01N33/68

摘要： The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US20230184768A1

公开(公告)日：2023-06-15

申请号：US17997267

申请日：2021-04-30

申请人： MESO SCALE TECHNOLOGIES, LLC.

发明人： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  James WILBUR ,  Jeffery DEBAD ,  Christopher CAMPBELL ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Pu LIU ,  Paul GOODWIN

IPC分类号： G01N33/569 ,  G01N33/68

CPC分类号： G01N33/56983 ,  G01N33/6854 ,  G01N2333/11 ,  G01N2333/165 ,  G01N2469/20

摘要： The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US20240103002A1

公开(公告)日：2024-03-28

申请号：US18473064

申请日：2023-09-22

申请人： Meso Scale Technologies, LLC.

发明人： George SIGAL ,  Leonid DZANTIEV ,  Priscilla KRAI ,  Teri-Tu B. NGO

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  G01N2333/065 ,  G01N2333/07 ,  G01N2469/20

摘要： The invention relates to methods and kits for detecting one or more antibody biomarkers in a sample, wherein the antibody biomarker specifically binds a viral antigen. In embodiments, the viral antigen is a monkeypox virus (MPXV) antigen, a vaccinia virus (VACV) antigen, or combination thereof.