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公开(公告)号:US08845969B2
公开(公告)日:2014-09-30
申请号:US13135369
申请日:2011-06-30
申请人: Mahalaxmi Gita Bangera , Michael H. Baym , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人: Mahalaxmi Gita Bangera , Michael H. Baym , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
CPC分类号: G01N31/223 , D03D15/00 , D10B2401/20 , G08B21/245 , Y10T428/239
摘要: A multilayer material is described herein that includes at least one signaling layer configured to propagate at least one electromagnetic signal; and a flexible layer configured to enclose the at least one signaling layer, wherein the flexible layer is substantially impermeable to an environment and to the at least one electromagnetic signal. The multilayer material including the at least one signaling layer is configured to transmit a change in the at least one electromagnetic signal upon exposure of the signaling layer to the environment. A system, an article of clothing, or a method is described herein.
摘要翻译: 本文描述了多层材料,其包括被配置为传播至少一个电磁信号的至少一个信令层; 以及柔性层,其被配置为包围所述至少一个信令层,其中所述柔性层对于环境和所述至少一个电磁信号基本上不可渗透。 包括至少一个信令层的多层材料被配置为在信令层暴露于环境时传输至少一个电磁信号的变化。 本文描述了系统,服装或方法。
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公开(公告)号:US08715576B2
公开(公告)日:2014-05-06
申请号:US12927968
申请日:2010-11-29
申请人: Mahalaxmi Gita Bangera , Michael H. Baym , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人: Mahalaxmi Gita Bangera , Michael H. Baym , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
IPC分类号: G05B9/00
CPC分类号: G01N31/223 , D03D15/00 , D10B2401/20 , G08B21/245 , Y10T428/239
摘要: A multilayer material is described herein that includes at least one signaling layer configured to propagate at least one electromagnetic signal; and a flexible layer configured to enclose the at least one signaling layer, wherein the flexible layer is substantially impermeable to an environment and to the at least one electromagnetic signal. The multilayer material including the at least one signaling layer is configured to transmit a change in the at least one electromagnetic signal upon exposure of the signaling layer to the environment. A system, an article of clothing, or a method is described herein.
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公开(公告)号:US08501103B2
公开(公告)日:2013-08-06
申请号:US12927972
申请日:2010-11-29
申请人: Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人: Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
IPC分类号: G05B9/00
CPC分类号: G01N31/223 , D03D15/00 , D10B2401/20 , G08B21/245 , Y10T428/239
摘要: A multilayer material is described herein that includes a flexible inner layer and a flexible outer layer configured to enclose at least one signaling layer, the at least one signaling layer including at least one chemical compound. The multilayer material including the chemical compound within the at least one signaling layer is configured to release a gas-phase chemical compound to signal to a detector indicating a breach of the multilayer material. A multilayer material, a system, an article of clothing, or a method is described herein.
摘要翻译: 本文描述了一种多层材料,其包括柔性内层和柔性外层,其被配置为包围至少一个信号层,所述至少一个信号层包括至少一种化学化合物。 包括至少一个信号层内的化合物的多层材料被配置为释放气相化合物以向检测器发出信号,指示破坏多层材料。 本文描述了多层材料,系统,服装或方法。
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公开(公告)号:US20120135527A1
公开(公告)日:2012-05-31
申请号:US12927972
申请日:2010-11-29
申请人: Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人: Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号: G01N31/223 , D03D15/00 , D10B2401/20 , G08B21/245 , Y10T428/239
摘要: A multilayer material is described herein that includes a flexible inner layer and a flexible outer layer configured to enclose at least one signaling layer, the at least one signaling layer including at least one chemical compound. The multilayer material including the chemical compound within the at least one signaling layer is configured to release a gas-phase chemical compound to signal to a detector indicating a breach of the multilayer material. A multilayer material, a system, an article of clothing, or a method is described herein.
摘要翻译: 本文描述了一种多层材料,其包括柔性内层和柔性外层,其被配置为包围至少一个信号层,所述至少一个信号层包括至少一种化学化合物。 包括至少一个信号层内的化合物的多层材料被配置为释放气相化合物以向检测器发出信号,指示破坏多层材料。 本文描述了多层材料,系统,服装或方法。
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公开(公告)号:US20120133507A1
公开(公告)日:2012-05-31
申请号:US12927968
申请日:2010-11-29
申请人: Mahalaxmi Gita Bangera , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人: Mahalaxmi Gita Bangera , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号: G01N31/223 , D03D15/00 , D10B2401/20 , G08B21/245 , Y10T428/239
摘要: A multilayer material is described herein that includes at least one signaling layer configured to propagate at least one electromagnetic signal; and a flexible layer configured to enclose the at least one signaling layer, wherein the flexible layer is substantially impermeable to an environment and to the at least one electromagnetic signal. The multilayer material including the at least one signaling layer is configured to transmit a change in the at least one electromagnetic signal upon exposure of the signaling layer to the environment. A system, an article of clothing, or a method is described herein.
摘要翻译: 本文描述了多层材料,其包括被配置为传播至少一个电磁信号的至少一个信令层; 以及柔性层,其被配置为包围所述至少一个信令层,其中所述柔性层对于环境和所述至少一个电磁信号基本上不可渗透。 包括至少一个信令层的多层材料被配置为在信令层暴露于环境时传输至少一个电磁信号的变化。 本文描述了系统,服装或方法。
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公开(公告)号:US20120133504A1
公开(公告)日:2012-05-31
申请号:US13135369
申请日:2011-06-30
申请人: Mahalaxmi Gita Bangera , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人: Mahalaxmi Gita Bangera , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
IPC分类号: G08B21/00
CPC分类号: G01N31/223 , D03D15/00 , D10B2401/20 , G08B21/245 , Y10T428/239
摘要: A multilayer material is described herein that includes at least one signaling layer configured to propagate at least one electromagnetic signal; and a flexible layer configured to enclose the at least one signaling layer, wherein the flexible layer is substantially impermeable to an environment and to the at least one electromagnetic signal. The multilayer material including the at least one signaling layer is configured to transmit a change in the at least one electromagnetic signal upon exposure of the signaling layer to the environment. A system, an article of clothing, or a method is described herein.
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公开(公告)号:US09617157B2
公开(公告)日:2017-04-11
申请号:US12322367
申请日:2009-01-30
申请人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
CPC分类号: C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
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公开(公告)号:US09187330B2
公开(公告)日:2015-11-17
申请号:US12283908
申请日:2008-09-15
申请人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
CPC分类号: C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要: Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
摘要翻译: 描述了提供靶向脂质双层膜的管状纳米结构的装置,组合物和方法。 目标管状纳米结构可以具有被配置为穿过细胞的脂质双层膜的表面区域,侧壁有两个亲水性表面区域的疏水性表面区域,所述疏水性表面区域配置成在细胞器官细胞器的脂质双层膜中形成孔,以及至少一个 配体被配置为结合细胞器的脂质双层膜上的一个或多个同源物。 靶细胞可以是例如受试者中的肿瘤细胞,感染细胞或患病细胞。 管状纳米结构可以在细胞器(例如线粒体)的脂质双层膜中形成孔,其可以允许至少一种化合物跨过膜的转运或易位并导致靶细胞的细胞死亡。
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公开(公告)号:US09199044B2
公开(公告)日:2015-12-01
申请号:US13567921
申请日:2012-08-06
申请人: Mahalaxmi Gita Bangera , Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, Jr.
发明人: Mahalaxmi Gita Bangera , Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, Jr.
CPC分类号: A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要: Wearable injection guides and manufacture and use thereof are described, which include: a rigid material formed to substantially conform in shape to a topography of a body region of an individual, the rigid material substantially impenetrable to an injection needle, and the rigid material including one or more injection needle access regions arranged in a treatment pattern.
摘要翻译: 描述了可穿戴的注射引导件及其制造和使用,其包括:刚性材料,形成为基本上符合个体的身体区域的形状,刚性材料基本上不可渗透到注射针,并且刚性材料包括一个 或更多的注射针入口区域以治疗图案排列。
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公开(公告)号:US20140039658A1
公开(公告)日:2014-02-06
申请号:US13568033
申请日:2012-08-06
申请人: Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, JR.
发明人: Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, JR.
IPC分类号: G06F17/50
CPC分类号: A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要: Systems and methods for wearable injection guides are described, which include: acquiring one or more digital images of a body region of an individual with at least one image capture device; creating a digitally rendered model of a wearable injection guide from the one or more digital images of the body region of the individual; adding one or more digitally rendered fiducials indicative of at least one treatment parameter to the digitally rendered model of the wearable injection guide; and forming the wearable injection guide from the digitally rendered model of the wearable injection guide, the formed wearable injection guide including one or more fiducials corresponding to the one or more digitally rendered fiducials on the digitally rendered model of the wearable injection guide.
摘要翻译: 描述了可穿戴式注射引导件的系统和方法,其包括:用至少一个图像捕获装置获取个体的身体区域的一个或多个数字图像; 从个体的身体区域的一个或多个数字图像创建可戴式注射引导件的数字渲染模型; 将指示至少一个治疗参数的一个或多个数字呈现的基准添加到所述可佩戴注射引导件的数字渲染模型; 以及从所述可穿戴式注射导向器的数字渲染模型形成所述可穿戴式注射导向器,所述可穿戴式注射引导件包括与所述可穿戴注射导向器的数字渲染模型上的所述一个或多个数字呈现的基准相对应的一个或多个基准。
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