公开(公告)号：US20090148943A1

公开(公告)日：2009-06-11

申请号：US12265348

申请日：2008-11-05

申请人： Makoto TAKEUCHI ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

发明人： Makoto TAKEUCHI ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

IPC分类号： C12N5/06

CPC分类号： C07K14/4705 ,  A61K38/00

摘要： The present invention has an object to provide a means to effectively enhance the production of cytokines and/or chemokines in mammals. The object is solved by providing an agent for enhancing the production of cytokines and/or chemokines, which comprises, as an effective ingredient, a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3; a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3, where one or more amino acids thereof are deleted or replaced with other amino acid(s) and/or one or more amino acids are added thereunto, without substantially losing the biological activity of the polypeptide.

摘要翻译： 本发明的目的是提供有效增强哺乳动物中细胞因子和/或趋化因子的产生的方法。 通过提供用于增强细胞因子和/或趋化因子的产生的试剂来解决该问题，所述试剂包含作为有效成分的具有SEQ ID NO：1至3的任一氨基酸序列的多肽; 具有SEQ ID NO：1至3的任何一个氨基酸序列的多肽，其中一个或多个氨基酸被缺失或被其它氨基酸和/或一个或多个氨基酸所取代，而没有 基本上丧失了多肽的生物活性。

公开(公告)号：US20070110711A1

公开(公告)日：2007-05-17

申请号：US11583148

申请日：2006-10-19

申请人： Makoto Takeuchi ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

发明人： Makoto Takeuchi ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

IPC分类号： A61K38/19 ,  C07K14/52

CPC分类号： C07K14/4705 ,  A61K38/00

摘要： The present invention has an object to provide a means to effectively enhance the production of cytokines and/or chemokines in mammals. The object is solved by providing an agent for enhancing the production of cytokines and/or chemokines, which comprises, as an effective ingredient, a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3; a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3, where one or more amino acids thereof are deleted or replaced with other amino acid(s) and/or one or more amino acids are added thereunto, without substantially losing the biological activity of the polypeptide.

摘要翻译： 本发明的目的是提供有效增强哺乳动物中细胞因子和/或趋化因子的产生的方法。 通过提供用于增强细胞因子和/或趋化因子的产生的试剂来解决该问题，所述试剂包含作为有效成分的具有SEQ ID NO：1至3的任一氨基酸序列的多肽; 具有SEQ ID NO：1至3的任何一个氨基酸序列的多肽，其中一个或多个氨基酸被缺失或被其它氨基酸和/或一个或多个氨基酸加入，而没有 基本上丧失了多肽的生物活性。