公开(公告)号：US20090148943A1

公开(公告)日：2009-06-11

申请号：US12265348

申请日：2008-11-05

申请人： Makoto TAKEUCHI ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

发明人： Makoto TAKEUCHI ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

IPC分类号： C12N5/06

CPC分类号： C07K14/4705 ,  A61K38/00

摘要： The present invention has an object to provide a means to effectively enhance the production of cytokines and/or chemokines in mammals. The object is solved by providing an agent for enhancing the production of cytokines and/or chemokines, which comprises, as an effective ingredient, a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3; a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3, where one or more amino acids thereof are deleted or replaced with other amino acid(s) and/or one or more amino acids are added thereunto, without substantially losing the biological activity of the polypeptide.

摘要翻译： 本发明的目的是提供有效增强哺乳动物中细胞因子和/或趋化因子的产生的方法。 通过提供用于增强细胞因子和/或趋化因子的产生的试剂来解决该问题，所述试剂包含作为有效成分的具有SEQ ID NO：1至3的任一氨基酸序列的多肽; 具有SEQ ID NO：1至3的任何一个氨基酸序列的多肽，其中一个或多个氨基酸被缺失或被其它氨基酸和/或一个或多个氨基酸所取代，而没有 基本上丧失了多肽的生物活性。

公开(公告)号：US20070110711A1

公开(公告)日：2007-05-17

申请号：US11583148

申请日：2006-10-19

申请人： Makoto Takeuchi ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

发明人： Makoto Takeuchi ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

IPC分类号： A61K38/19 ,  C07K14/52

CPC分类号： C07K14/4705 ,  A61K38/00

摘要： The present invention has an object to provide a means to effectively enhance the production of cytokines and/or chemokines in mammals. The object is solved by providing an agent for enhancing the production of cytokines and/or chemokines, which comprises, as an effective ingredient, a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3; a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3, where one or more amino acids thereof are deleted or replaced with other amino acid(s) and/or one or more amino acids are added thereunto, without substantially losing the biological activity of the polypeptide.

摘要翻译： 本发明的目的是提供有效增强哺乳动物中细胞因子和/或趋化因子的产生的方法。 通过提供用于增强细胞因子和/或趋化因子的产生的试剂来解决该问题，所述试剂包含作为有效成分的具有SEQ ID NO：1至3的任一氨基酸序列的多肽; 具有SEQ ID NO：1至3的任何一个氨基酸序列的多肽，其中一个或多个氨基酸被缺失或被其它氨基酸和/或一个或多个氨基酸加入，而没有 基本上丧失了多肽的生物活性。

公开(公告)号：US5731193A

公开(公告)日：1998-03-24

申请号：US828511

申请日：1997-03-31

申请人： Tetsuya Mori ,  Kozo Yamamoto ,  Tsunetaka Ohta

发明人： Tetsuya Mori ,  Kozo Yamamoto ,  Tsunetaka Ohta

IPC分类号： C12N15/09 ,  C07K14/505 ,  C07K14/56 ,  C12N5/10 ,  C12N15/85 ,  C07H21/04 ,  C12N15/67 ,  C12P21/02

CPC分类号： C12N15/85 ,  C07K14/505 ,  C07K14/56 ,  C12N2830/00 ,  C12N2830/42 ,  C12N2830/85

摘要： Insertion of IFN-alpha promoters in recombinant DNAs improves their expression efficiencies for useful polypeptides. Expression of such a recombinant DNA in host cells of mammalian origin is artificially controllable by the presence and absence of external stimuli using IFN-alpha inducers. Thus, transformants with such a recombinant DNA readily increase to a maximized cell density with causing neither damages nor extinction due to polypeptides they produce, and subsequent exposure to IFN-alpha inducers allows the proliferated cells to efficiently produce polypeptides with significant glycosylations.

摘要翻译： 在重组DNA中插入IFN-α启动子改善了其对有用多肽的表达效率。 这种重组DNA在哺乳动物来源的宿主细胞中的表达可以通过使用IFN-α诱导物的外部刺激的存在和不存在来人为可控。 因此，具有这种重组DNA的转化体容易增加到最大化的细胞密度，由于它们产生的多肽而不造成损伤或消灭，随后暴露于IFN-α诱导物允许增殖的细胞有效地产生具有显着糖基化的多肽。

公开(公告)号：US09297951B2

公开(公告)日：2016-03-29

申请号：US14381115

申请日：2012-09-13

申请人： Tetsuya Mori ,  Kimio Moriya

发明人： Tetsuya Mori ,  Kimio Moriya

IPC分类号： G02B6/028 ,  G02B6/122 ,  G02B6/036 ,  G02B6/125

CPC分类号： G02B6/028 ,  G02B6/036 ,  G02B6/1221 ,  G02B6/125

摘要： A core layer (13) of an optical waveguide (1) includes a plurality of core groups (140) disposed so as to mutually intersect on the same plane, each core group (140) being an assembly of a plurality of core portions (14), at least some of which are arranged in parallel, and side cladding portions (15) provided so as to adjoin the side surfaces of each core portion (14). A transverse cross-section of the optical waveguide (1) includes a high refractive index region (WH) in a position corresponding with each core portion (14) and having a relatively high refractive index, and a low refractive index region (WL) in a position corresponding with each side cladding portion (15) and having a lower refractive index than the high refractive index region (WH), and a refractive index distribution is formed in which the refractive index varies continuously across the entire distribution.

摘要翻译： 光波导（1）的芯层（13）包括设置成在相同平面上相互交叉的多个芯组（140），每个芯组（140）是多个芯部（14）的组件 ），其中至少一些平行布置，以及设置成邻接每个芯部（14）的侧表面的侧包层部分（15）。 光波导（1）的横截面包括在与每个芯部分（14）对应的位置并且具有相对较高折射率的位置处的高折射率区域（WH）和低折射率区域 与每个侧包层部分（15）相对应并具有比高折射率区域（WH）低的折射率的位置，并且形成折射率分布，其中折射率在整个分布上连续变化。

公开(公告)号：US20150016794A1

公开(公告)日：2015-01-15

申请号：US14381115

申请日：2012-09-13

申请人： Tetsuya Mori ,  Kimio Moriya

发明人： Tetsuya Mori ,  Kimio Moriya

IPC分类号： G02B6/028 ,  G02B6/036

CPC分类号： G02B6/028 ,  G02B6/036 ,  G02B6/1221 ,  G02B6/125

摘要： A core layer (13) of an optical waveguide (1) includes a plurality of core groups (140) disposed so as to mutually intersect on the same plane, each core group (140) being an assembly of a plurality of core portions (14), at least some of which are arranged in parallel, and side cladding portions (15) provided so as to adjoin the side surfaces of each core portion (14). A transverse cross-section of the optical waveguide (1) includes a high refractive index region (WH) in a position corresponding with each core portion (14) and having a relatively high refractive index, and a low refractive index region (WL) in a position corresponding with each side cladding portion (15) and having a lower refractive index than the high refractive index region (WH), and a refractive index distribution is formed in which the refractive index varies continuously across the entire distribution.

摘要翻译： 光波导（1）的芯层（13）包括设置成在相同平面上相互交叉的多个芯组（140），每个芯组（140）是多个芯部（14）的组件 ），其中至少一些平行布置，以及设置成邻接每个芯部（14）的侧表面的侧包层部分（15）。 光波导（1）的横截面包括在与每个芯部分（14）对应的位置并且具有相对较高折射率的位置处的高折射率区域（WH）和低折射率区域 与每个侧包层部分（15）相对应并具有比高折射率区域（WH）低的折射率的位置，并且形成折射率分布，其中折射率在整个分布上连续变化。

公开(公告)号：US08588566B2

公开(公告)日：2013-11-19

申请号：US12997136

申请日：2009-06-09

申请人： Mutsuhiro Matsuyama ,  Koji Choki ,  Tetsuya Mori ,  Kei Watanabe

发明人： Mutsuhiro Matsuyama ,  Koji Choki ,  Tetsuya Mori ,  Kei Watanabe

IPC分类号： G02B6/26 ,  G02B6/42 ,  G02B6/36

CPC分类号： G02B6/43 ,  G02B6/14 ,  G02B6/4214 ,  G02B6/4246 ,  H01R35/02 ,  H05K1/0274 ,  H05K1/028 ,  H05K1/148 ,  H05K2201/051

摘要： According to the electronic apparatus and cellular phone of the present invention, in an optical waveguide forming body of a flexible cable, an air layer is provided in a deforming section which experiences bending deformation as a result of the movement of a second body relative to a first body (either a pivoting or sliding movement), and the position of this air layer becomes located on the outer circumferential side of a core when the deforming section undergoes bending deformation. As a result of this, it is possible to ensure sufficient flexibility and to also achieve a sufficient improvement in the folding endurance of the core portion for this optical waveguide forming body to be utilized in practical applications. Moreover, it is possible to suppress light loss and achieve high-speed, large-capacity transmissions even when the optical waveguide forming body of a flexible cable experiences bending deformation due to the relative movement of the second body relative to the first body.

摘要翻译： 根据本发明的电子设备和便携式电话机，在柔性电缆的光波导形成体中，空气层设置在变形部分中，该变形部分由于第二主体相对于第二主体的运动而经历弯曲变形 第一体（旋转或滑动运动），并且当变形部经历弯曲变形时，该空气层的位置位于芯的外周侧。 作为其结果，可以确保足够的灵活性，并且还可以实现在实际应用中用于该光波导形成体的芯部的折叠耐久性的充分改善。 此外，即使当柔性电缆的光波导形成体由于第二主体相对于第一主体的相对运动而遭受弯曲变形时，也可以抑制光损失并实现高速，大容量传输。

公开(公告)号：US08361628B2

公开(公告)日：2013-01-29

申请号：US12675579

申请日：2008-11-14

申请人： Seiji Nakajima ,  Tetsuo Hayase ,  Tetsuya Mori

发明人： Seiji Nakajima ,  Tetsuo Hayase ,  Tetsuya Mori

IPC分类号： B32B15/08 ,  B32B15/04 ,  B05D3/10 ,  C08G63/00

CPC分类号： H05K3/387 ,  C23C18/06 ,  C23C18/08 ,  C23C18/14 ,  C23C18/1667 ,  C23C18/1678 ,  C23C18/1893 ,  C23C18/2086 ,  C23C18/31 ,  G02B5/0808 ,  G02B27/1073 ,  G02B27/144 ,  H05K3/181 ,  H05K2203/1157 ,  H05K2203/121 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31692

摘要： The present invention provides (i) a process for producing a metal film with which process a metal film and a metal pattern can be formed, at low cost, on an arbitrary substrate, (ii) a primer composition, (iii) a metal film, and (iv) use of the metal film. The process includes the steps of: forming an organic film with use of a primer composition which contains (i) an addition polymerizable compound including three or more reactive groups, (ii) an addition polymerizable compound including an acid group, (iii) an addition polymerizable compound including a basic group, and (iv) an addition polymerizable compound including a hydrophilic functional group; form a metal (M1) salt from the acid group; substituting the metal (M1) salt of the acid group with a metal (M2) salt by processing with a metal (M2) ion aqueous solution containing a metal (M2) ion which has a less ionization tendency than the metal (M1) ion; and reducing the metal (M2) ion so that a metal film is formed on a surface of the organic film.

摘要翻译： 本发明提供（i）金属膜的制造方法，可以在任意的基材上以低成本形成金属膜和金属图案，（ii）底漆组合物，（iii）金属膜 ，和（iv）使用金属膜。 该方法包括以下步骤：使用底漆组合物形成有机膜，该底漆组合物包含（i）包含三个或更多个反应性基团的加成聚合性化合物，（ii）包含酸基的加聚性化合物，（iii） 包含碱性基团的可聚合化合物，和（iv）包含亲水官能团的加成聚合性化合物; 从酸基形成金属（M1）盐; 用含金属（M2）离子的金属（M2）离子水溶液加工，用金属（M2）盐代替金属（M1）盐，电离倾向比金属（M1）离子少; 并且还原金属（M2）离子，使得在有机膜的表面上形成金属膜。

公开(公告)号：US20120064458A1

公开(公告)日：2012-03-15

申请号：US13206611

申请日：2011-08-10

申请人： Koji CHOKI ,  Tetsuya Mori ,  Ramakrishna Ravikiran ,  Makoto Fujiwara ,  Keizo Takahama ,  Kei Watanabe ,  Hirotaka Nonaka ,  Yumiko Otake ,  Andrew Bell ,  Larry Rhodes ,  Dino Amoroso ,  Mutsuhiro Matsuyama

发明人： Koji CHOKI ,  Tetsuya Mori ,  Ramakrishna Ravikiran ,  Makoto Fujiwara ,  Keizo Takahama ,  Kei Watanabe ,  Hirotaka Nonaka ,  Yumiko Otake ,  Andrew Bell ,  Larry Rhodes ,  Dino Amoroso ,  Mutsuhiro Matsuyama

IPC分类号： G03F7/004

CPC分类号： G02B6/1221 ,  C08F232/00 ,  G02B6/138 ,  Y10S430/106 ,  Y10S430/114

摘要： Embodiments in accordance with the present invention provide waveguide structures and methods of forming such structures where core and laterally adjacent cladding regions are defined. Some embodiments of the present invention provide waveguide structures where core regions are collectively surrounded by laterally adjacent cladding regions and cladding layers and methods of forming such structures.

摘要翻译： 根据本发明的实施例提供了形成这样的结构的波导结构和方法，其中限定了芯和横向相邻的包层区。 本发明的一些实施例提供了波导结构，其中芯部区域被横向相邻的包层区域和包覆层共同包围，并且形成这种结构的方法。

公开(公告)号：US07869670B2

公开(公告)日：2011-01-11

申请号：US12302627

申请日：2007-05-30

申请人： Koji Choki ,  Mutsuhiro Matsuyama ,  Kenji Miyao ,  Keizo Takahama ,  Tetsuya Mori ,  Kei Watanabe ,  Hiroshi Owari ,  Yoji Shirato

发明人： Koji Choki ,  Mutsuhiro Matsuyama ,  Kenji Miyao ,  Keizo Takahama ,  Tetsuya Mori ,  Kei Watanabe ,  Hiroshi Owari ,  Yoji Shirato

IPC分类号： G02B6/10 ,  G02B6/12

CPC分类号： G02B6/4231 ,  G02B6/4214 ,  H01L25/167 ,  H01L2224/16225 ,  H05K1/0274 ,  H05K1/181 ,  H05K3/4614

摘要： A substrate on which an optical element is mounted is provided, including: an optical element; an optical circuit substrate which is formed by an optical waveguide layer having a core portion and cladding portions; and an electrical circuit substrate on which is provided a mounting portion that is used for mounting the optical element, wherein the optical element is mounted on the electrical circuit substrate via the optical circuit substrate and wherein the optical circuit substrate has an optical element mounted thereon and is provided with a receptor structure having a conductive portion that conducts electricity between an electrode of the optical element and an electrode of the electrical circuit substrate.

摘要翻译： 提供安装有光学元件的基板，包括：光学元件; 由具有芯部和包层部的光波导层形成的光电路基板; 以及电路基板，其上设置有用于安装光学元件的安装部分，其中所述光学元件经由所述光学电路基板安装在所述电路基板上，并且其中所述光学电路基板具有安装在其上的光学元件， 设置有具有在光学元件的电极和电路基板的电极之间传导电力的导电部分的接收器结构。

公开(公告)号：US07745671B2

公开(公告)日：2010-06-29

申请号：US10576030

申请日：2004-10-14

申请人： Masanori Yamaguchi ,  Yuichi Kita ,  Tetsuya Mori ,  Kenji Kanbe ,  Akihiro Tomoda ,  Atsushi Takahashi ,  Wakako Ichikawa

发明人： Masanori Yamaguchi ,  Yuichi Kita ,  Tetsuya Mori ,  Kenji Kanbe ,  Akihiro Tomoda ,  Atsushi Takahashi ,  Wakako Ichikawa

IPC分类号： C07C35/16 ,  C07H1/06 ,  C07C35/46

CPC分类号： C12P7/02 ,  C07C29/145 ,  C12N9/0004 ,  C12N9/0006 ,  C12P7/18 ,  C12P7/26

摘要： It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.

摘要翻译： 旨在提供一种新的NAD +独立肌醇2-脱氢酶，其在不存在NAD +的情况下将肌醇转化为鲨肌内糖; 在NADH或NADPH的存在下，立体选择性地将鲨肌内糖降解成鲨肌醇的新型鲨肌醇肌醇脱氢酶; 和属于醋杆菌属或伯克霍尔德氏菌属的新型微生物，可将肌醇转化为鲨肌醇。 通过使用这些酶或微生物，产生鲨肌醇。 此外，通过向含有鲨肌醇和除了鲨肌醇之外的中性糖的液体混合物中加入硼酸和金属盐以形成鲨肌醇/硼酸络合物，将所述络合物与液体混合物分离，将鲨肌醇纯化 将如此分离的络合物溶解在酸中，得到酸性溶液或酸性悬浮液，然后从酸性溶液或酸性悬浮液中纯化鲨肌醇。