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公开(公告)号：US20170173221A1
公开(公告)日：2017-06-22
申请号：US15124639
申请日：2015-03-10
申请人： Manav Mehta , Hisashi Tsukada , 3-D MATRIX, LTD.
CPC分类号： A61L31/047 , A61B17/12104 , A61B17/12181 , A61B17/12186 , A61K38/07 , A61K49/006 , A61L31/028 , A61L31/14 , A61L31/145 , A61L31/16 , A61L2300/442 , A61L2400/06 , A61L2400/12 , A61L2430/36
摘要： Materials and methods for forming a bronchial obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to provide a bronchial obstruction.
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公开(公告)号：US20170173105A1
公开(公告)日：2017-06-22
申请号：US15124638
申请日：2015-03-10
申请人： Manav Mehta , Hisashi Tsukada , 3-D MATRIX, LTD.
CPC分类号： A61K38/07 , A61K2121/00 , A61L26/0047 , A61L26/008 , A61L2400/06
摘要： Materials and methods for treatment of pulmonary leakage are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary leakage.
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公开(公告)号：US20170072008A1
公开(公告)日：2017-03-16
申请号：US15124636
申请日：2015-03-10
申请人： Manav Mehta , Hisashi Tsukada , 3-D MATRIX, LTD.
CPC分类号： A61K38/16 , A61B17/34 , A61K38/08 , A61K38/10 , A61M16/0463
摘要： Materials and methods for treatment of pulmonary bulla are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary bulla.
摘要翻译： 提供了治疗肺泡的材料和方法。 在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。 可以在目标部位提供水凝胶屏障以便治疗肺大疱。
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公开(公告)号：US20220160939A1
公开(公告)日：2022-05-26
申请号：US17529600
申请日：2021-11-18
申请人： 3-D MATRIX, LTD.
摘要： Materials and methods for forming a bronchial obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to provide a bronchial obstruction.
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公开(公告)号：US10654893B2
公开(公告)日：2020-05-19
申请号：US15121251
申请日：2015-03-10
申请人： 3-D MATRIX, LTD.
发明人： Eun Seok Gil , Karl Gilbert , Manav Mehta
摘要： The present disclosure provides peptide compositions (e.g., of self-assembling peptides) with particular attributes (e.g., peptide identity, peptide concentration, pH, ionic strength [including salt identity and/or concentration), etc. that show particularly useful material properties. The present disclosure also provides technologies for selecting and/or formulating particular peptide compositions useful in specific contexts. In some embodiments, provided peptide compositions have an elevated pH within the range of about 2.5 to about 3.5 and/or an ionic strength that is above that of a corresponding composition of the same peptide, at the same concentration, in water, but is below a critical salt point for the peptide (e.g., so that the composition is not cloudy).
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公开(公告)号：US10245299B2
公开(公告)日：2019-04-02
申请号：US15124636
申请日：2015-03-10
申请人： 3-D MATRIX, LTD.
发明人： Manav Mehta , Hisashi Tsukada , Eun Seok Gil , Karl Gilbert , Satoru Kobayashi
摘要： Materials and methods for treatment of pulmonary bulla are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary bulla.
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公开(公告)号：US20160362451A1
公开(公告)日：2016-12-15
申请号：US15121251
申请日：2015-03-10
申请人： 3-D MATRIX, LTD.
发明人： Eun Seok Gil , Karl Patrick Gilbert , Manav Mehta
IPC分类号： C07K7/08
摘要： The present disclosure provides peptide compositions (e.g., of self-assembling peptides) with particular attributes (e.g., peptide identity, peptide concentration, pH, ionic strength [including salt identity and/or concentration), etc that show particularly useful material properties. The present disclosure also provides technologies for selecting and/or formulating particular peptide compositions useful in specific contexts. In some embodiments, provided peptide compositions have an elevated pH within the range of about 2.5 to about 3.5 and/or an ionic strength that is above that of a corresponding composition of the same peptide, at the same concentration, in water, but is below a critical salt point for the peptide (e.g., so that the composition is not cloudy).
摘要翻译： 本公开提供具有特别有用的材料性质的特定属性（例如肽同一性，肽浓度，pH，离子强度（包括盐同一性和/或浓度）等）的肽组合物（例如自组装肽）。 本公开还提供了用于选择和/或配制在特定上下文中有用的特定肽组合物的技术。 在一些实施方案中，所提供的肽组合物具有在约2.5至约3.5范围内的升高的pH值和/或高于相同肽在相同浓度的水中的相应组合物的离子强度，但低于 肽的临界盐点（例如，使得组合物不浑浊）。
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公开(公告)号：US20150050735A1
公开(公告)日：2015-02-19
申请号：US14459816
申请日：2014-08-14
申请人： 3-D MATRIX, LTD.
发明人： Solomon Iyasere , Meagan Lazor , Eun Seok Gil , Manav Mehta
摘要： Well plates for use in various laboratory experiments may include a plurality of wells each having an interior wall that includes a ledge positioned at a fixed depth within the well.
摘要翻译： 用于各种实验室实验的井板可以包括多个井，每个孔具有内壁，所述内壁包括位于井内的固定深度处的凸缘。
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