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13 条记录 (耗时 0.022 秒)

    Single-source precursor for semiconductor nanocrystals
    3.
    发明授权
    Single-source precursor for semiconductor nanocrystals 有权
    半导体纳米晶体的单源前体

    公开(公告)号：US08287951B2

    公开(公告)日：2012-10-16

    申请号：US12088590

    申请日：2006-06-27

    申请人： Manzoor Koyakutty ,  Aditya Verma ,  Sampat Raj Vedera ,  Narendra Kumar ,  Thundyil Raman Narayana Kutty

    发明人： Manzoor Koyakutty ,  Aditya Verma ,  Sampat Raj Vedera ,  Narendra Kumar ,  Thundyil Raman Narayana Kutty

    IPC分类号： B05D7/00

    CPC分类号： H01L33/285 ,  C09K11/642 ,  C30B7/00 ,  C30B29/16 ,  C30B29/48 ,  C30B29/605 ,  Y10T428/2991

    摘要： A process for preparing a single source solid precursor matrix for semiconductor nanocrystals having the steps of: mixing 0.1-1 Molar of an aqueous/non-aqueous (organic) solution containing the first component of the host matrix with 0.001-0.01 Molar of an aqueous/non-aqueous solution containing the first dopant ions, which needs in situ modification of valency state, dissolving 10-20 milligram of an inorganic salt for the in situ reduction of the first dopant ion in the solution, addition of 0.001-0.01 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the dopant ions which do not need modifications of their valency state, addition of 0.1-1 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the second component of the host material, addition of 5-10% by weight of an aqueous solution containing a pH modifying complexing agent, to obtain a mixture, and heating the mixture to obtain a solid layered micro-structural precursor compound.

    摘要翻译： 制备用于半导体纳米晶体的单源固体前体基质的方法，其具有以下步骤：将含有主体基质的第一组分的0.1-1摩尔水/非水（有机）溶液与0.001-0.01摩尔的水性 /含有第一掺杂剂离子的非水溶液，其需要原位改性的价态，将10-20毫克的无机盐溶解在溶液中原位还原第一掺杂剂离子，加入0.001-0.01摩尔 含有不需要改变其价态的掺杂剂离子的无机盐的水/非水溶液，加入0.1-1摩尔含有主体第二组分的无机盐的水/非水溶液 添加5-10重量％的含有pH改性络合剂的水溶液，得到混合物，加热混合物，得到固体层状微结构前体化合物。

    Single-Source Precursor for Semiconductor Nanocrystals
    4.
    发明申请
    Single-Source Precursor for Semiconductor Nanocrystals 有权
    半导体纳米晶体的单源前体

    公开(公告)号：US20090218550A1

    公开(公告)日：2009-09-03

    申请号：US12088590

    申请日：2006-06-27

    申请人： Manzoor Koyakutty ,  Aditya Verma ,  Sampat Raj Vedera ,  Narendra Kumar ,  Thundyil Raman Narayana Kutty

    发明人： Manzoor Koyakutty ,  Aditya Verma ,  Sampat Raj Vedera ,  Narendra Kumar ,  Thundyil Raman Narayana Kutty

    IPC分类号： H01B1/22 ,  C01G9/08 ,  C09K3/00

    CPC分类号： H01L33/285 ,  C09K11/642 ,  C30B7/00 ,  C30B29/16 ,  C30B29/48 ,  C30B29/605 ,  Y10T428/2991

    摘要： A process for preparing a single source solid precursor matrix for semiconductor nanocrystals having the steps of: mixing 0.1-1 Molar of an aqueous/non-aqueous (organic) solution containing the first component of the host matrix with 0.001-0.01 Molar of an aqueous/non-aqueous solution containing the first dopant ions, which needs in situ modification of valency state, dissolving 10-20 milligram of an inorganic salt for the in situ reduction of the first dopant ion in the solution, addition of 0.001-0.01 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the dopant ions which do not need modifications of their valency state, addition of 0.1-1 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the second component of the host material, addition of 5-10% by weight of an aqueous solution containing a pH modifying complexing agent, to obtain a mixture, and heating the mixture to obtain a solid layered micro-structural precursor compound.

    摘要翻译： 制备用于半导体纳米晶体的单源固体前体基质的方法，其具有以下步骤：将含有主体基质的第一组分的0.1-1摩尔水/非水（有机）溶液与0.001-0.01摩尔的水性 /含有第一掺杂剂离子的非水溶液，其需要原位改性的价态，将10-20毫克的无机盐溶解在溶液中原位还原第一掺杂剂离子，加入0.001-0.01摩尔 含有不需要改变其价态的掺杂剂离子的无机盐的水/非水溶液，加入0.1-1摩尔含有主体第二组分的无机盐的水/非水溶液 添加5-10重量％的含有pH改性络合剂的水溶液，得到混合物，加热混合物，得到固体层状微结构前体化合物。

    Methods of screening for Janus kinase 3 interacting compounds
    5.
    发明授权
    Methods of screening for Janus kinase 3 interacting compounds 有权

    公开(公告)号：US09739779B2

    公开(公告)日：2017-08-22

    申请号：US15135950

    申请日：2016-04-22

    申请人： Narendra Kumar ,  Jayshree Mishra

    发明人： Narendra Kumar ,  Jayshree Mishra

    IPC分类号： G01N33/53 ,  G01N33/573 ,  C12Q1/48

    CPC分类号： G01N33/573 ,  C07K2319/23 ,  C12Q1/485 ,  G01N2333/912 ,  G01N2500/04

    摘要： The present invention provides a method for screening compounds for their ability to inhibit autophosphorylation of Janus kinase 3 in the absence of any additional substrate. The present invention also provides a method for screening compounds that bind to Janus kinase 3 domains other than the kinase domain, to identify synthetic or natural compounds including biomolecules, that modulate Janus kinase 3 activity. This invention also describes a multi-component screening kit composed of purified recombinant Janus kinase 3 proteins and recombinant phosphorylated Janus kinase 3 fusion proteins including, one or more phosphorylated or non-phosphorylated domain-deleted Janus kinase 3 fusion proteins.

    Novel High Throughput Assay for finding new Jak3 Interacting Compounds, Biomolecules, and Inhibitors.
    7.
    发明申请
    Novel High Throughput Assay for finding new Jak3 Interacting Compounds, Biomolecules, and Inhibitors. 审中-公开
    用于寻找新的Jak3相互作用化合物，生物分子和抑制剂的新型高通量测定法。

    公开(公告)号：US20150344934A1

    公开(公告)日：2015-12-03

    申请号：US14483622

    申请日：2014-09-11

    申请人： Narendra Kumar ,  Jayshree Mishra

    发明人： Narendra Kumar ,  Jayshree Mishra

    IPC分类号： C12Q1/48

    CPC分类号： C12Q1/485 ,  C07K2319/23 ,  G01N2333/912 ,  G01N2500/04

    摘要： Janus Kinase 3 is a non-receptor tyrosine kinase that mediates signals initiated by cytokines through interactions with the receptors of cytokines. Abnormal activation of Jak3 was associated with human hematologic and epithelial malignancies. Inhibitors of Jak3 have shown utility in many different disease such as autoimmune disorders, allograft rejection during transplantation, acute lymphoblastic leukemia, Type 1 diabetes, rheumatoid arthritis and allergy and asthma. Since these inhibitors make their way into clinical trials with profound effects, it is essential to develop a sensitive, precise, and rugged screening tool to screen synthetic compounds or other biomolecules that has the potential to modulate Jak3 functions and hence treat a wide variety of diseases. Present invention relates to novel high throughput system for finding previously unknown Jak3 interacting compounds, human biomolecule (e.g. proteins or others), and those compounds that can inhibit Jak3 activations. All these identified compounds and molecules can be used for the treatment of a wide variety of diseases (listed in table 1) where Jak3 activations or its interactions with other biomolecules are essential for disease sustenance or propagation in human body.

    摘要翻译： Janus Kinase 3是一种非受体酪氨酸激酶，其通过与细胞因子受体的相互作用介导由细胞因子引发的信号。 Jak3的异常活化与人类血液学和上皮性恶性肿瘤有关。 Jak3的抑制剂已经显示出在许多不同疾病中的用途，例如自身免疫性疾病，移植期间的同种异体移植物排斥反应，急性成淋巴细胞白血病，1型糖尿病，类风湿性关节炎和变态反应和哮喘。 由于这些抑制剂进入具有深远影响的临床试验，因此必须开发一种灵敏，精确和坚固的筛选工具来筛选合成化合物或其他可能调节Jak3功能并因此治疗各种疾病的生物分子 。 本发明涉及用于发现先前未知的Jak3相互作用化合物，人类生物分子（例如蛋白质或其他物质）的新型高通量系统以及可抑制Jak3激活的那些化合物。 所有这些鉴定的化合物和分子可用于治疗各种各样的疾病（列于表1中），其中Jak3激活或其与其他生物分子的相互作用对于在人体中的疾病维持或传播是必需的。

    Zeolite catalyst for skeletal isomerisation of olefins
    9.
    发明授权
    Zeolite catalyst for skeletal isomerisation of olefins 有权
    用于烯烃骨架异构化的沸石催化剂

    公开(公告)号：US07604794B2

    公开(公告)日：2009-10-20

    申请号：US10549169

    申请日：2004-03-09

    申请人： Marja Tiitta ,  Elina Harlin ,  Jaana Makkonen ,  Narendra Kumar ,  Dmitry Yu Murzin ,  Tapio Salmi

    发明人： Marja Tiitta ,  Elina Harlin ,  Jaana Makkonen ,  Narendra Kumar ,  Dmitry Yu Murzin ,  Tapio Salmi

    IPC分类号： C01B39/04 ,  C01B39/48 ,  C07C5/27

    CPC分类号： C10G45/64 ,  B01J29/7046 ,  B01J29/87 ,  C01B39/48 ,  C07C5/2708 ,  C07C2529/70 ,  C07C11/02 ,  C07C11/09 ,  C07C11/10 ,  C07C11/107

    摘要： The present invention relates to an active and selective zeolite catalyst having MTT structure that is useful in skeletal isomerisation of light olefins. The method for the manufacture of the zeolite catalyst having MTT structure comprises the steps of a) preparing of a gel mixture capable of forming crystalline material, and the mixture comprising sources of alkali or alkaline earth metal (M), of an oxide of a trivalent element (X), of an oxide of a tetravalent element (Y), water and a directing agent (R), and the mixture having a composition, in terms of molar ratios, within the given ranges; b) maintaining the mixture under sufficient conditions, including a temperature of from about 100° C. to about 250° C., under dynamic mode of stirring until crystals of the material are formed, recovering the material; and c) removing the directing agent (R) partly or totally with a calcination procedure.

    摘要翻译： 本发明涉及具有MTT结构的活性和选择性沸石催化剂，其可用于轻质烯烃的骨架异构化。 制备具有MTT结构的沸石催化剂的方法包括以下步骤：a）制备能够形成结晶材料的凝胶混合物，以及包含碱金属或碱土金属（M）源的混合物，其为三价氧化物 元素（X），四价元素（Y）的氧化物，水和导向剂（R）的组分，所述混合物的摩尔比在组合物的给定范围内; b）在动态搅拌模式下将混合物保持在足够的条件下，包括约100℃至约250℃的温度，直到形成材料晶体，回收材料; 和c）用煅烧程序部分或全部地去除引导剂（R）。

    Zeolite catalyst for skeletal isomerisation of olefins
    10.
    发明申请
    Zeolite catalyst for skeletal isomerisation of olefins 有权
    用于烯烃骨架异构化的沸石催化剂

    公开(公告)号：US20060275207A1

    公开(公告)日：2006-12-07

    申请号：US10549169

    申请日：2004-03-09

    申请人： Marja Tiitta ,  Elina Harlin ,  Jaana Makkonen ,  Narendra Kumar ,  Dintry Yu Murzin ,  Tapio Salmi

    发明人： Marja Tiitta ,  Elina Harlin ,  Jaana Makkonen ,  Narendra Kumar ,  Dintry Yu Murzin ,  Tapio Salmi

    IPC分类号： C01B39/00 ,  B01J29/06

    CPC分类号： C10G45/64 ,  B01J29/7046 ,  B01J29/87 ,  C01B39/48 ,  C07C5/2708 ,  C07C2529/70 ,  C07C11/02 ,  C07C11/09 ,  C07C11/10 ,  C07C11/107

    摘要： The present invention relates to an active and selective zeolite catalyst having MTT structure that is useful in skeletal isomerisation of light olefins. It also relates to a method for the manufacture of said catalyst. The method for the manufacture of the zeolite catalyst having MTT structure comprises the steps of a) Preparing of a gel mixture capable of forming crystalline material, and said mixture comprising sources of alkali or alkaline earth metal (M,) of an oxide of a trivalent element (X), of an oxide of a tetravalent element (Y), water and a directing agent (R), and said mixture having a composition, in terms of molar ratios, within the following ranges; (I) b) Maintaining of said mixture under sufficient conditions, including a temperature of from about 100° C. to about 250° C., under dynamic mode of stirring until crystals of said material are formed, recovering the material, and b) Removing of said directing agent (R) partly or totally with a calcination procedure, whereby a zeolite catalyst having MTT structure is obtained.

    摘要翻译： 本发明涉及具有MTT结构的活性和选择性沸石催化剂，其可用于轻质烯烃的骨架异构化。 它还涉及制备所述催化剂的方法。 制备具有MTT结构的沸石催化剂的方法包括以下步骤：a）制备能够形成结晶材料的凝胶混合物，所述混合物包含三价氧化物的碱金属或碱土金属（M i）源， 元素（X），四价元素（Y）的氧化物，水和导向剂（R），所述混合物的摩尔比在下列范围内的组成： （I）b）在充分的条件下，包括约100℃至约250℃的温度，在动态搅拌模式下保持所述混合物，直至形成所述材料的晶体，回收该材料，和b） 通过煅烧步骤部分或全部除去所述导向剂（R），由此得到具有MTT结构的沸石催化剂。